Fabrication and characterisation of gelatin-hyaluronic acid/nanobioactive glass hybrid scaffolds for tissue engineering

Zhou, Zhi‐Hua; Cao, Dafu; Huang, Tianlong; Liu, L. L.; Liu, Q. Q.; Zhao, Yanmin; Ou, Baoli; Zeng, Wenhua; Xu, Guiyin; Tang, Anping; Yang, Zhaorong

doi:10.1179/1433075x13y.0000000095

Cited by 12 publications

(3 citation statements)

References 25 publications

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“…Additionally, all samples exhibit a suitable pore size range for migration and proliferation of cells as well as vascularization. The pore size range was found to be similar to freeze-dried hydrogels containing BG based on gelatin-hyaluronic acid [61], alginate [62], collagen-hyaluronic acid [63], and MH-containing cryogels (without BG) based on silk fibroin [19,64] and gelatin [18]. However, compared to other studies using silk-based lyophilized foams [65] and gelatin-chitosan foams [66,67] containing BG, which show less porosity and pore size ranges, the present MC-MH based foams containing BG appear to be more suitable for tissue-engineering applications based on their pore structure.…”

Section: Morphology Of Foamsmentioning

confidence: 73%

Manuka honey and bioactive glass impart methylcellulose foams with antibacterial effects for wound-healing applications

et al. 2020

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Wound dressings able to deliver topically bioactive molecules represent a new generation of wound-regeneration therapies. In this article, foams based on methylcellulose cross-linked with Manuka honey were used as a platform to deliver borate bioactive glass particles doped additionally with copper. Borate bioactive glasses are of great interest in wound-healing applications due to a combination of favorable features, such as angiogenic and antibacterial properties. The multifunctional composite providing the dual effect of the bioactive glass and Manuka honey was produced by freeze-drying, and the resulting foams exhibit suitable morphology characterized by high porosity. Moreover, the performed tests showed improved wettability and mechanical performance with the addition of bioactive glass particles. Dissolution studies using simulated body fluid and cell biology tests using relevant skin cells further proved the excellent bioactivity and positive effects of the foams on cell proliferation and migration. Most interestingly, by the dual release of Manuka honey and ions from the copper-doped bioactive glass, an antibacterial effect against E. coli and S. aureus was achieved. Therefore, the multifunctional foams showed promising outcomes as potential wound dressings for the treatment of infected wounds.

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Section: Morphology Of Foamsmentioning

confidence: 73%

Manuka honey and bioactive glass impart methylcellulose foams with antibacterial effects for wound-healing applications

et al. 2020

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“…Since gelatin has a high film‐forming capacity, it is used to produce polymeric films. Gelatin (Gel) is also biocompatible and soluble at body temperature, which are desirable properties for biomedical fields such as controlled drug release and tissue engineering . Poly(ethylene oxide) (PEO) is used to fabricate polymeric films, since it consists of flexible polymer chains that produce soft polymeric films with water‐uptake capacity by crosslinking .…”

Section: Introductionmentioning

confidence: 99%

Electroconductive hyaluronic acid/gelatin/poly(ethylene oxide) polymeric film reinforced by reduced graphene oxide

Kaya

Alemdar

2018

J of Applied Polymer Sci

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Novel electroconductive polymeric films with enhanced mechanical performance were fabricated by encapsulating reduced graphene oxide (RGO) at different concentrations (0–50 vol %) into a hyaluronic acid/gelatin/poly(ethylene oxide) (HyA/Gel/PEO) polymeric structure. The obtained RGO‐reinforced polymeric films were characterized by Fourier transform infrared and scanning electron microscopy analyses. Mechanical performances were measured with a universal mechanical testing machine. The results verified that the RGO reinforcement significantly enhanced the mechanical performances of the films. To determine the biocompatibility of the polymeric films, L929 (murine fibroblast) cell lines were used. The water uptake capacities were measured using swelling tests. A four‐probe method was used to measure conductivity characteristics. The conductivity results indicated that HyA/Gel/PEO film containing 20 vol % RGO has the highest average electrical conductivity (1.832 × 10−6 S/cm). All of the results demonstrated that the obtained electroconductive films could be used in biomedical fields in the future, especially in controlled drug release systems and tissue engineering. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 46905.

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“…Bone tissue loss and damage caused by injuries or diseases have emerged as one of the most troubling problems that jeopardize human health. − However, current substitutes including autografts, allografts, and xenografts are not satisfactory because of limited availability, donor site morbidity, immune reaction, risk of infection, etc. − Thus, artificial bone grafts are in high demand. − There are currently many bone graft substitute materials such as inorganic materials (hydroxyapatite (HA), bioactive glass, etc. ) ,,, and biodegradable polymers (poly(lactic acid) (PLA), poly lactic- co -glycolic acid (PLGA), gelatin, etc.…”

Section: Introductionmentioning

confidence: 99%

Bioactive Nanoparticle–Gelatin Composite Scaffold with Mechanical Performance Comparable to Cancellous Bones

Wang

Shen

Tian

et al. 2014

ACS Appl. Mater. Interfaces

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Mechanical properties are among the most concerned issues for artificial bone grafting materials. The scaffolds used for bone grafts are either too brittle (glass) or too weak (polymer), and therefore composite scaffolds are naturally expected as the solution. However, despite the intensive studies on composite bone grafting materials, there still lacks a material that could be matched to the natural cancellous bones. In this study, nanosized bioactive particles (BP) with controllable size and good colloidal stability were used to composite with gelatin, forming macroporous scaffolds. It was found that the mechanical properties of obtained composite scaffolds, in terms of elastic modulus, compressive strength, and strain at failure, could match to that of natural cancellous bones. This is ascribed to the good distribution of particle in matrix and strong interaction between particle and gelatin. Furthermore, the incorporation of BPs endues the composite scaffolds with bioactivity, forming HA upon reacting with simulated body fluid (SBF) within days, thus stimulating preosteoblasts attachment, growth, and proliferation in these scaffolds. Together with their good mechanical properties, these composite scaffolds are promising artificial bone grating materials.

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Fabrication and characterisation of gelatin-hyaluronic acid/nanobioactive glass hybrid scaffolds for tissue engineering

Cited by 12 publications

References 25 publications

Manuka honey and bioactive glass impart methylcellulose foams with antibacterial effects for wound-healing applications

Manuka honey and bioactive glass impart methylcellulose foams with antibacterial effects for wound-healing applications

Electroconductive hyaluronic acid/gelatin/poly(ethylene oxide) polymeric film reinforced by reduced graphene oxide

Bioactive Nanoparticle–Gelatin Composite Scaffold with Mechanical Performance Comparable to Cancellous Bones

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