Fabrication and cellular interactions of nanoporous tantalum oxide

Uslu, Ece; Öztatlı, Hayriye; Gari̇pcan, Bora; Ercan, Batur

doi:10.1002/jbm.b.34604

Cited by 18 publications

(27 citation statements)

References 32 publications

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“…The increase in NT diameter was also evident comparing the bottom views of the NT features (insets for Figure b,c). For the NC samples, a 1 M H 2 SO 4 + 3.3 wt % NH 4 F aqueous solution was used as the electrolyte and the anodization potential was kept constant at 20 V. Similar to previously published results in our research group, the high water content inside the electrolyte led to the formation of nanoporous surface morphology. In addition, a comparison of these findings with our previous publication showed that the formation of nanoporous structures was independent of the F-ion source used inside the electrolyte.…”

Section: Results and Discussionmentioning

confidence: 59%

“…For instance, Ma et al observed that the adhesion, proliferation, and differentiation of mouse osteocytes increased upon the decrease in NT tantalum diameter from 126 to 56 nm . A similar trend was also observed for nanoporous tantalum where surfaces having 25 nm pore size enhanced fibroblast adhesion and proliferation compared to the ones having 65 nm pore size and nonporous tantalum . The observed changes in the biological properties with changes in anodized surface feature size were not specific to tantalum; anodized NT titanium and its alloys also expressed size dependent changes in their cellular functions.…”

Section: Introductionmentioning

confidence: 79%

“…35 A similar trend was also observed for nanoporous tantalum where surfaces having 25 nm pore size enhanced fibroblast adhesion and proliferation compared to the ones having 65 nm pore size and nonporous tantalum. 36 The observed changes in the biological properties with changes in anodized surface feature size were not specific to tantalum; anodized NT titanium and its alloys also expressed size dependent changes in their cellular functions. For instance, Oh et al correlated a decrease in the anodized NT titanium feature size with an increase in mesenchymal stem cell surface density, while an increase in the nanotube feature size upregulated ALP, osteocalcin, and osteopontin gene expressions.…”

Section: Introductionmentioning

confidence: 90%

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Nanofeature Size and Morphology of Tantalum Oxide Surfaces Control Osteoblast Functions

Uslu

Mimiroglu

Ercan

2021

ACS Appl. Bio Mater.

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Tantalum is one of the most corrosion-resistant materials and has mechanical properties that are suitable for orthopedic applications. However, tantalum exhibits bioinert characteristics and cannot promote the desired level of osseointegration with juxtaposed bone tissues. To enhance the bioactivity of tantalum, nanoscale surface modifications via anodization could be a potential approach. In this study, surface features having nanotubular, nanodimple, and nanocoral morphologies were fabricated onto tantalum by controlling anodization parameters. Aside from altering the surface morphology, nanotubular, nanodimple, and nanocoral feature sizes were precisely fine-tuned between the 20 and 140 nm range. The results indicated that anodized surfaces consisted of Ta2O5 and non-stoichiometric tantalum suboxide chemistry. Upon the anodization, surface area of the tantalum samples increased up to 2-fold, which was accompanied by up to a 3.5-folds increase in the nanophase surface roughness. Biological studies showed that anodized tantalum surfaces significantly enhanced protein adsorption and improved bone cell proliferation and spreading independently of the anodized surface morphology and feature size. Nanodimple surfaces having a 90 nm feature size promoted 50% more bone cell proliferation and 23% more cellular spreading compared to non-anodized tantalum. Nanodimple surfaces also enhanced alkaline phosphatase activity and increased Ca mineral deposition up to 5 weeks compared to non-anodized tantalum, indicating higher bioactivity. In this study, biological interactions of anodized tantalum surfaces having different morphologies and feature sizes were examined, for the first time, and the potential use of nanostructured tantalum was highlighted for orthopedic applications.

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Section: Results and Discussionmentioning

confidence: 59%

Section: Introductionmentioning

confidence: 79%

Section: Introductionmentioning

confidence: 90%

See 1 more Smart Citation

Nanofeature Size and Morphology of Tantalum Oxide Surfaces Control Osteoblast Functions

Uslu

Mimiroglu

Ercan

2021

ACS Appl. Bio Mater.

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“…Fabrication of Ta 2 O 5 nanotube layers on the surface by anodization [ 195 , 196 ] or micro-arc oxidation (MAO) [ 207 ] is another approach to ameliorate the bioactivity of Ta. With the formation of nanotubes, the Ca and P elements contained in electrolytes can be incorporated into the oxide nanotubes by either of the aforementioned methods [ 208 ].…”

Section: New Development Of Porous Ta For Bone Tissue Engineeringmentioning

confidence: 99%

The Clinical Application of Porous Tantalum and Its New Development for Bone Tissue Engineering

2021

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Porous tantalum (Ta) is a promising biomaterial and has been applied in orthopedics and dentistry for nearly two decades. The high porosity and interconnected pore structure of porous Ta promise fine bone ingrowth and new bone formation within the inner space, which further guarantee rapid osteointegration and bone–implant stability in the long term. Porous Ta has high wettability and surface energy that can facilitate adherence, proliferation and mineralization of osteoblasts. Meanwhile, the low elastic modulus and high friction coefficient of porous Ta allow it to effectively avoid the stress shield effect, minimize marginal bone loss and ensure primary stability. Accordingly, the satisfactory clinical application of porous Ta-based implants or prostheses is mainly derived from its excellent biological and mechanical properties. With the advent of additive manufacturing, personalized porous Ta-based implants or prostheses have shown their clinical value in the treatment of individual patients who need specially designed implants or prosthesis. In addition, many modification methods have been introduced to enhance the bioactivity and antibacterial property of porous Ta with promising in vitro and in vivo research results. In any case, choosing suitable patients is of great importance to guarantee surgical success after porous Ta insertion.

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“…Fabrication of Ta2O5 nanotube layers on the surface by anodization [197,198] or micro-arc oxidation (MAO) [199] is another approach to ameliorate bioactivity of Ta. With the formation of nanotubes, Ca and P elements containing in electrolyte can be incorporated into the oxide nanotubes by the either aforementioned methods [200].…”

Section: Cytotoxicity (Mc3t3-e1 Cells) •mentioning

confidence: 99%

The Clinical Application of Porous Tantalum and Its New Development for Bone Tissue Engineering

Huang¹,

Pan²,

Qiu³

2021

Preprint

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Porous tantalum (Ta) is a promising biomaterial and has been applied in orthopedics and dentistry for nearly two decades. The high porosity and interconnected pore structure of porous Ta promise fine bone ingrowth and new bone formation within the inner space, which further guarantee rapid osteointegration and bone-implant stability in long term. Porous Ta has high wettability and surface energy that can facilitate adherence, proliferation and mineralization of osteoblasts. Meanwhile, low elastic modulus and high friction coefficient of porous Ta can effectively avoid stress shield effect, minimize marginal bone loss and ensure primary stability. Accordingly, the satisfactory clinical application of porous Ta based implants or prostheses are mainly derived from its excellent biological and mechanical properties. With the advent of additive manufacturing, personalized porous Ta based implants or prostheses have shown their clinical value in the treatment of individual patient who need specially designed implant or prosthesis. In addition, many modification methods have been introduced to enhance the bioactivity and antibacterial property of porous Ta with promising in vitro and in vivo research results. In any case, choosing suitable patients is of great importance to guarantee surgical success after porous Ta insertion.

show abstract

Fabrication and cellular interactions of nanoporous tantalum oxide

Cited by 18 publications

References 32 publications

Nanofeature Size and Morphology of Tantalum Oxide Surfaces Control Osteoblast Functions

Nanofeature Size and Morphology of Tantalum Oxide Surfaces Control Osteoblast Functions

The Clinical Application of Porous Tantalum and Its New Development for Bone Tissue Engineering

The Clinical Application of Porous Tantalum and Its New Development for Bone Tissue Engineering

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