volume 191, issue 8, P4048-4058 2013
DOI: 10.4049/jimmunol.1301315
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Debasis Pore, Neetha Parameswaran, Ken Matsui, Matthew B. Stone, Ichiko Saotome, Andrea I. McClatchey, Sarah L. Veatch, Neetu Gupta

Abstract: Ezrin is a member of the Ezrin-Radixin-Moesin (ERM) family of membrane-actin cytoskeleton crosslinkers that participate in a variety of cellular processes. In B cells, phosphorylation of ezrin at different sites regulates multiple processes such as lipid raft coalescence, BCR diffusion, microclustering, and endosomal JNK activation. In this study, we generated mice with conditional deletion of ezrin in the B cell lineage to investigate the physiological significance of ezrin’s function in antigen receptor-med…

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