Eyelid Oleogranulomas Caused by Petroleum Jelly Injection

Ointment Granulomas Following Sutureless Transconjunctival Blepharoplasty

“…10 Other descriptive idioms include sclerosing lipogranulomas, 11,12 lipogranulomas, [13][14][15][16] lipid granulomas, 13 Lacrilube cysts, oil granulomas, 17 oleogranulomas, 17,18 and Vaselinoma. 19 Petrolatum jelly products are composed of saturated hydrocarbons known as n-alcanes that are indigestible by cellular enzymes.…”

“…Similar granulomas have resulted from ointments in nasal packing after sinonasal surgery. 10,22,23 They have been reported in the orbit, eyelids, and lacrimal sac following cosmetic self-injection, 18 exposure to pressurized hydraulic oil during explosion, 24 usage of petroleum-based radiopaque markers during surgery, 19,25 and therapeutic lacrimal duct injection. 13,26 The complication has occurred when ointment was introduced into the socket after enucleation 10,27 and following transcanalicular injection in laser canaliculoplasty.…”

Ointment Granulomas Following Sutureless Transconjunctival Blepharoplasty

“…10 Other descriptive idioms include sclerosing lipogranulomas, 11,12 lipogranulomas, [13][14][15][16] lipid granulomas, 13 Lacrilube cysts, oil granulomas, 17 oleogranulomas, 17,18 and Vaselinoma. 19 Petrolatum jelly products are composed of saturated hydrocarbons known as n-alcanes that are indigestible by cellular enzymes.…”

“…Similar granulomas have resulted from ointments in nasal packing after sinonasal surgery. 10,22,23 They have been reported in the orbit, eyelids, and lacrimal sac following cosmetic self-injection, 18 exposure to pressurized hydraulic oil during explosion, 24 usage of petroleum-based radiopaque markers during surgery, 19,25 and therapeutic lacrimal duct injection. 13,26 The complication has occurred when ointment was introduced into the socket after enucleation 10,27 and following transcanalicular injection in laser canaliculoplasty.…”

Palpebral Lipogranuloma Caused by Transcanalicular Ointment Injection After Laser Canaliculoplasty

“…Frozen sections stained with oil red O or Sudan IV can facilitate the identification of lipids that appear as empty spaces on paraffin sections. 11,13 The differential diagnosis of lipogranuloma secondary to a chalazion should be considered, and morphologic comparison of the vacuoles between the 2 kinds of lipogranulomas in paraffin sections might be helpful. 9 Sclerosing lipogranulomas share similar clinical and histopathologic features with lipogranulomas caused by exogenous lipids.…”

“…The polymorphic vacuoles representing spaces filled by exogenous lipid were also observed in macrophages and fibroblasts, 11 suggesting that the exogenous lipid was phagocytosed by histiocytes, transported to adjacent lymph nodes, and then scattered throughout the reticuloendothelial system. 13 The onset of a lipogranulomatous reaction occurs from weeks to years after petroleum jelly injection. 14 Only a single case of an acute inflammatory response was reported.…”

Orbital Lipogranuloma after Sinus Surgery

“…Orbital lipogranuloma is described as a local histiocytic response to extracellular lipid or alloplastic material, including silicone and paraffin (4)(5)(6). It has been demonstrated as secondary to a ruptured dermoid cyst (4).…”

Ointment Granulomas Following Sutureless Transconjunctival Blepharoplasty

“…10 Other descriptive idioms include sclerosing lipogranulomas, 11,12 lipogranulomas, [13][14][15][16] lipid granulomas, 13 Lacrilube cysts, oil granulomas, 17 oleogranulomas, 17,18 and Vaselinoma. 19 Petrolatum jelly products are composed of saturated hydrocarbons known as n-alcanes that are indigestible by cellular enzymes.…”

“…Similar granulomas have resulted from ointments in nasal packing after sinonasal surgery. 10,22,23 They have been reported in the orbit, eyelids, and lacrimal sac following cosmetic self-injection, 18 exposure to pressurized hydraulic oil during explosion, 24 usage of petroleum-based radiopaque markers during surgery, 19,25 and therapeutic lacrimal duct injection. 13,26 The complication has occurred when ointment was introduced into the socket after enucleation 10,27 and following transcanalicular injection in laser canaliculoplasty.…”

Palpebral Lipogranuloma Caused by Transcanalicular Ointment Injection After Laser Canaliculoplasty

“…Frozen sections stained with oil red O or Sudan IV can facilitate the identification of lipids that appear as empty spaces on paraffin sections. 11,13 The differential diagnosis of lipogranuloma secondary to a chalazion should be considered, and morphologic comparison of the vacuoles between the 2 kinds of lipogranulomas in paraffin sections might be helpful. 9 Sclerosing lipogranulomas share similar clinical and histopathologic features with lipogranulomas caused by exogenous lipids.…”

“…The polymorphic vacuoles representing spaces filled by exogenous lipid were also observed in macrophages and fibroblasts, 11 suggesting that the exogenous lipid was phagocytosed by histiocytes, transported to adjacent lymph nodes, and then scattered throughout the reticuloendothelial system. 13 The onset of a lipogranulomatous reaction occurs from weeks to years after petroleum jelly injection. 14 Only a single case of an acute inflammatory response was reported.…”

Orbital Lipogranuloma after Sinus Surgery

“…Orbital lipogranuloma is described as a local histiocytic response to extracellular lipid or alloplastic material, including silicone and paraffin (4)(5)(6). It has been demonstrated as secondary to a ruptured dermoid cyst (4).…”

Ointment Granulomas Following Sutureless Transconjunctival Blepharoplasty

“…10 Other descriptive idioms include sclerosing lipogranulomas, 11,12 lipogranulomas, [13][14][15][16] lipid granulomas, 13 Lacrilube cysts, oil granulomas, 17 oleogranulomas, 17,18 and Vaselinoma. 19 Petrolatum jelly products are composed of saturated hydrocarbons known as n-alcanes that are indigestible by cellular enzymes.…”

“…Similar granulomas have resulted from ointments in nasal packing after sinonasal surgery. 10,22,23 They have been reported in the orbit, eyelids, and lacrimal sac following cosmetic self-injection, 18 exposure to pressurized hydraulic oil during explosion, 24 usage of petroleum-based radiopaque markers during surgery, 19,25 and therapeutic lacrimal duct injection. 13,26 The complication has occurred when ointment was introduced into the socket after enucleation 10,27 and following transcanalicular injection in laser canaliculoplasty.…”

Palpebral Lipogranuloma Caused by Transcanalicular Ointment Injection After Laser Canaliculoplasty

“…Frozen sections stained with oil red O or Sudan IV can facilitate the identification of lipids that appear as empty spaces on paraffin sections. 11,13 The differential diagnosis of lipogranuloma secondary to a chalazion should be considered, and morphologic comparison of the vacuoles between the 2 kinds of lipogranulomas in paraffin sections might be helpful. 9 Sclerosing lipogranulomas share similar clinical and histopathologic features with lipogranulomas caused by exogenous lipids.…”

“…The polymorphic vacuoles representing spaces filled by exogenous lipid were also observed in macrophages and fibroblasts, 11 suggesting that the exogenous lipid was phagocytosed by histiocytes, transported to adjacent lymph nodes, and then scattered throughout the reticuloendothelial system. 13 The onset of a lipogranulomatous reaction occurs from weeks to years after petroleum jelly injection. 14 Only a single case of an acute inflammatory response was reported.…”

Orbital Lipogranuloma after Sinus Surgery

“…Orbital lipogranuloma is described as a local histiocytic response to extracellular lipid or alloplastic material, including silicone and paraffin (4)(5)(6). It has been demonstrated as secondary to a ruptured dermoid cyst (4).…”