Eyelid Margin Basal Cell Carcinoma Managed With Full-Thickness En-Face Frozen Section Histopathology

Gill, Hartej; Moscato, Eve E.; Seiff, Stuart R.

doi:10.1097/iop.0b013e3182a74f21

Cited by 17 publications

(7 citation statements)

References 33 publications

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“…Eyelid margin SGC was excised with full-thickness en-face frozen section-controlled technique as described by Gill et al 12. The main lesion was excised, followed by excision of 1 mm full-thickness medial, lateral and inferior/superior margins to make up for a 5 mm margin.…”

Section: Methodsmentioning

confidence: 99%

14-year case series of eyelid sebaceous gland carcinoma in Chinese patients and review of management

Lam

Yuen

2018

Br J Ophthalmol

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Section: Methodsmentioning

confidence: 99%

14-year case series of eyelid sebaceous gland carcinoma in Chinese patients and review of management

Lam

Yuen

2018

Br J Ophthalmol

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“…Recurrence rates after frozen section controlled excision were reported as 1.7% by Gayre et al, 13 4% by Nemet et al, 10 0.7% by Wong et al, 24 0.26% by Ho et al 25 and 1.3% by Gill et al, 26 while no recurrence was observed by Conway et al 27 after 5 years, by Taherian et al 28 after 38 months or by Akbaş Kocaoğlu et al 29 in Turkey after 18.7 months of follow-up.…”

Section: Discussionmentioning

confidence: 98%

The Importance of Frozen Section-Controlled Excision in Recurrent Basal Cell Carcinoma of the Eyelids

Şahan¹,

Çiftçi²,

Özkan³

et al. 2016

tjo

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Objectives: To show the importance of frozen section-controlled excision to avoid the re-recurrence of recurrent basal cell carcinoma (BCC) of the eyelids.Materials and Methods: Thirty-five cases who underwent eyelid tumor excision in different centers and were admitted to our clinic with recurrent eyelid tumors. Recurrent tumors were resected by excision 1-2 mm from the tumor’s visible margin and sent to pathology for frozen section examination. Eyelid reconstructions with flap and graft were performed after confirming that the surgical margins were negative.Results: Twenty-one (60%) of our patients were male and 14 (40%) were female. Median age of our group was 63.4±14.2 years. Excision and sending the excised material for frozen section control was performed once for 11 patients, twice for 12 patients, 3 times for 8 patients and 4 times for 4 patients to confirm that the surgical margins were clean. All pathology samples were reported as BCC. All patients had eyelid reconstruction with flap and graft. Recurrence was detected in 2 patients (5.7%) during 1 to 8 years (mean 4.3 years) of follow-up and those patients were reoperated; no recurrence was detected in the remaining 33 patients (94.3%).Conclusion: Frozen section control can provide low re-recurrence rate in patients with recurrent BCC of the eyelids.

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“…The long-term benefits of Mohs surgery compared with other techniques is still unknown [26]. Full-thickness en-face frozen section has also been shown to be effective with comparable results to Mohs surgery for basal cell carcinoma [27,28]. In a recent report from MD Anderson Cancer Center, using complete surgical excision of SC with en-face margin evaluation on frozen section, the local recurrence rate was only 6% [9].…”

Section: Discussionmentioning

confidence: 99%

The practice patterns in the management of sebaceous carcinoma of the eyelid in the Asia Pacific region

Cheung

Esmaeli

Lam

et al. 2019

Eye

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Purpose To determine the practice patterns of ophthalmic plastic surgeons regarding the management of eyelid sebaceous carcinoma (SC). Methods An electronic survey was distributed to oculoplastic surgical colleagues in the Asia Pacific region requesting clinical information and treatment approaches to SC. Results The responses from 192 respondents from the Asia Pacific region was included and analyzed in this study. For initial diagnosis, most surgeons selected incisional biopsy (55%), followed by complete excision (35%). Initial workup was mainly by palpation of lymph nodes, chest X-ray, and computerized tomography scan (CT-scan) of the orbit. Conjunctival map biopsy was done in selected cases. Sentinel lymph node biopsy (SLNB) was done mainly for tumors larger than 10 mm. Management was mainly by surgical excision (5 mm margin) combined with adjuvant therapy in some cases, with radiotherapy being the most common. Margin status was determined most frequently by frozen section as evaluated by the pathologist (57%) followed by Mohs micrographic surgery (18%). Surveillance was based mainly on physical examination alone. Conclusion The Asia Pacific oculoplastic surgeons prefer incisional biopsy for lesions suspicious of SC prior to definitive surgery. This is in contrast to survey results previously reported in other populations. Frozen section control (done by an oculoplastic surgeon with pathology support) is most commonly used for margin control and conjunctival map biopsies are done only in selected cases. Despite the potential benefits of SLNB, access and expertise in this area is currently lacking in the Asia Pacific region.

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Eyelid Margin Basal Cell Carcinoma Managed With Full-Thickness En-Face Frozen Section Histopathology

Cited by 17 publications

References 33 publications

14-year case series of eyelid sebaceous gland carcinoma in Chinese patients and review of management

14-year case series of eyelid sebaceous gland carcinoma in Chinese patients and review of management

The Importance of Frozen Section-Controlled Excision in Recurrent Basal Cell Carcinoma of the Eyelids

The practice patterns in the management of sebaceous carcinoma of the eyelid in the Asia Pacific region

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