Eye and Behçet's disease

Ksiaa, Imen; Abroug, Nesrine; Kéchida, M.; Zina, Sourour; Jelliti, Béchir; Khochtali, Sana; Attia, S.; Khairallah, Moncef

doi:10.1016/j.jfo.2019.02.002

Cited by 60 publications

(53 citation statements)

References 64 publications

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“…Optic disc hyperemia is a constant feature of posterior segment in ammation and optic disc hyper uorescence is an early uorescein angiographic nding in patients with BD uveitis 3 . Other rare forms of optic nerve involvement have been described including optic neuritis, neuroretinitis, unilateral prepapillary vitreous exudate, and ischemic optic neuropathy 2 .…”

Section: Introductionmentioning

confidence: 99%

Sequential bilateral Behçet’s neuroretinitis associated with prepapillary vitreous exudate: case report

Ksiaa

Aoun

Zina

et al. 2021

Preprint

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Objective: To describe a case of Behçet disease (BD) uveitis manifesting with sequential bilateral neuroretinitis associated with prepapillary inflammatory vitreous exudate (PIVE). Material and Methods: A single case report documented with multimodal imaging.Results: A 37-year-old man developed neuroretinitis with associated PIVE in the left eye. He was diagnosed with ocular toxoplasmosis and treated accordingly based on positive serologic testing and negative work-up for other entities, including BD. The disease course was favorable, but one year later a similar neuroretinitis developed in the right eye. Extraocular features of BD became evident only at the time of the second eye involvement, and the patient received corticosteroid and immunosuppressive therapy. SS OCT showed at the acute phase in both eyes a typical “mushroom-shaped” prepapillary hyperreflectivity of the PIVE. SS OCTA demonstrated a corresponding prepapillary hypointense area due to shadowing effect, decreasing in size while scanning deeper layers. It also detected peripapillary retinal hypervascularity in both eyes and a sectoral area of flow signal loss in the first involved left eye. Visual acuity improved following the resolution of the PIVE and associated acute inflammatory changes in both eyes. The left eye showed residual optic disc pallor and retinal nerve fiber layer defects.Conclusion: Sequential bilateral neuroretinitis associated with PIVE may occur before other clinical features of BD become evident. SS OCT and OCTA can provide useful information for the diagnosis and management of this rare, but typical, ocular manifestation of BD uveitis.

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Section: Introductionmentioning

confidence: 99%

Sequential bilateral Behçet’s neuroretinitis associated with prepapillary vitreous exudate: case report

Ksiaa

Aoun

Zina

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Ocular BD is typically characterized by bilateral relapsing-remitting non granulomatous panuveitis with retinal vasculitis that may result in severe vision loss [1]. Several specific eye findings may help in the early diagnosis of BD uveitis and in differentiating this condition from other infectious and non-infectious uveitis entities [2,3]. These include shifting hypopyon, diffuse vitritis, inferior vitreous precipitates, transient superficial retinal infiltrates, occlusive retinal vasculitis, and fern-like retinal capillary leakage.…”

Section: Introductionmentioning

confidence: 99%

“…Optic disc hyperemia is a constant feature of posterior segment inflammation and optic disc hyperfluorescence is an early fluorescein angiographic finding in patients with BD uveitis [3]. Other rare forms of optic nerve involvement have been described including optic neuritis, neuroretinitis, unilateral prepapillary vitreous exudate, and ischemic optic neuropathy [2].…”

Section: Introductionmentioning

confidence: 99%

Sequential bilateral Behçet’s neuroretinitis associated with prepapillary vitreous exudate: case report

Ksiaa

Aoun

Zina

et al. 2020

J Ophthal Inflamm Infect

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Objective To describe a case of Behçet disease (BD) uveitis manifesting with sequential bilateral neuroretinitis associated with prepapillary inflammatory vitreous exudate (PIVE). Material and methods A single case report documented with multimodal imaging. Results A 37-year-old man developed neuroretinitis with associated PIVE in the left eye. He was diagnosed with ocular toxoplasmosis and treated accordingly based on positive serologic testing and negative work-up for other entities, including BD. The disease course was favorable, but 1 year later a similar neuroretinitis developed in the right eye. Extraocular features of BD became evident only at the time of the second eye involvement, and the patient received corticosteroid and immunosuppressive therapy. Swept source (SS) OCT showed at the acute phase in both eyes a typical “mushroom-shaped” prepapillary hyperreflectivity of the PIVE. SS OCT angiography (OCTA) demonstrated a corresponding prepapillary hypointense area due to shadowing effect, decreasing in size while scanning deeper layers. It also detected peripapillary retinal hypervascularity in both eyes and a sectoral area of flow signal loss in the first involved left eye. Visual acuity improved following the resolution of the PIVE and associated acute inflammatory changes in both eyes. The left eye showed residual optic disc pallor and retinal nerve fiber layer defects. Conclusion Sequential bilateral neuroretinitis associated with PIVE may occur before other clinical features of BD become evident. SS OCT and OCTA can provide useful information for the diagnosis and management of this rare, but typical, ocular manifestation of BD uveitis.

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“…The anterior chamber associated immune deviation (ACAID) mediates the protection of the eye from the deleterious effects of an adaptive immune response [11]. However, the eye is still susceptible to inflammation caused by systemic diseases such as cancer [12], multiple sclerosis [13], juvenile idiopathic arthritis [14], and vascular diseases such as Bechet's disease [15]. Autoimmune uveitis or uveoretinitis is the result of a systemic tolerance breakdown that leads to the generation of autoreactive T-cells (Th1 and Th17) which recognize retina specific antigens such as the interphotoreceptor retinoid binding protein (IRBP) or S-arrestin [16,17].…”

Section: Introductionmentioning

confidence: 99%

AAV Mediated Delivery of Myxoma Virus M013 Gene Protects the Retina against Autoimmune Uveitis

Ridley

Young

Lee

et al. 2019

JCM

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Uveoretinitis is an ocular autoimmune disease caused by the activation of autoreactive T- cells targeting retinal antigens. The myxoma M013 gene is known to block NF-κB (Nuclear Factor kappa-light-chain-enhancer of activated B cells) and inflammasome activation, and its gene delivery has been demonstrated to protect the retina against lipopolysaccharide (LPS)-induced uveitis. In this report we tested the efficacy of M013 in an experimental autoimmune uveoretinitis (EAU) mouse model. B10RIII mice were injected intravitreally with AAV (adeno associated virus) vectors delivering either secreted GFP (sGFP) or sGFP-TatM013. Mice were immunized with interphotorecptor retinoid binding protein residues 161–180 (IRBP161–180) peptide in complete Freund’s adjuvant a month later. Mice were evaluated by fundoscopy and spectral domain optical coherence tomography (SD-OCT) at 14 days post immunization. Eyes were evaluated by histology and retina gene expression changes were measured by reverse transcribed quantitative PCR (RT-qPCR). No significant difference in ERG or retina layer thickness was observed between sGFP and sGFP-TatM013 treated non-uveitic mice, indicating safety of the vector. In EAU mice, expression of sGFP-TatM013 strongly lowered the clinical score and number of infiltrative cells within the vitreous humor when compared to sGFP treated eyes. Retina structure was protected, and pro-inflammatory genes expression was significantly decreased. These results indicate that gene delivery of myxoma M013 could be of clinical benefit against autoimmune diseases.

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Eye and Behçet's disease

Cited by 60 publications

References 64 publications

Sequential bilateral Behçet’s neuroretinitis associated with prepapillary vitreous exudate: case report

Sequential bilateral Behçet’s neuroretinitis associated with prepapillary vitreous exudate: case report

Sequential bilateral Behçet’s neuroretinitis associated with prepapillary vitreous exudate: case report

AAV Mediated Delivery of Myxoma Virus M013 Gene Protects the Retina against Autoimmune Uveitis

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