Extrinsic Antibiotic-Resistant Mechanism in Bacteria

Sagar, Sadhana; Kaistha, Shilpa Deshpande; Das, Amar Jyoti; Kumar, Rajesh

doi:10.1007/978-981-13-9879-7_7

Cited by 5 publications

(5 citation statements)

References 88 publications

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“… 29 The occurrence of ciprofloxacin and imipenem resistance in E. coli is a concerning issue, since 1987 no new antibiotic has been discovered and imipenem is the last line of the drug to the gram-negative bacteria. 30 In the current study, the isolated E. coli E1 was resistant to various classes of antibiotics including imipenem. If the imipenem MDR bacteria continue to spread, it could be challenging to control the infection using a commercially available antibiotic.…”

Section: Resultsmentioning

confidence: 70%

Combined Effect of Isolated Bacteriophage and Neem Extract on Isolated Multiple Drug-Resistant Pathogenic Escherichia coli E1 From Well Water

Sagar,

Rani,

Pushpa Sadanandan

2023

Environ�Health�Insights

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Multiple drug-resistant Escherichia coli ( E. coli) is a serious cause of concern, and they can be observed in hospital settings, natural environment, and animals. Dissemination of multiple drug-resistant (MDR) E. coli can pose a high risk to public health. Moreover, they are hard to control with commercial antibiotics, since they have acquired resistance against most of them. Therefore, to control multiple drug-resistant bacteria, alternative strategies have been adopted such as phage therapy, herbal remedies, nanoparticles etc. In the current study, the combined application of neem leaf extract and bacteriophage is used to control an isolated multiple drug-resistant E. coli E1. We have applied 0.1 mg/ml concentration of neem extract in combination with an isolated phage vB_EcoM_C2 of 1011 titer and found that the combinatorial treatment approach significantly controls the growth of E. coli E1 as compared to a single non-combinatorial treatment. In this study, every E. coli cell is targeted by 2 antimicrobials (phage and neem extract) at the same time, which is more effective as compared to the sole treatment. Implementation of the neem extract with phage opens a new alternative approach to the chemotherapeutics for the control of multiple drug-resistant bacterial pathogens. This approach may be effective, economical, and eco-friendly to combat MDR.

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Section: Resultsmentioning

confidence: 70%

Combined Effect of Isolated Bacteriophage and Neem Extract on Isolated Multiple Drug-Resistant Pathogenic Escherichia coli E1 From Well Water

Sagar,

Rani,

Pushpa Sadanandan

2023

Environ�Health�Insights

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“…Notwithstanding this, the efficacy and enduring consequences of these methodologies remain incompletely comprehended. 199 The management of diseases such as MT , PA , SA , and leishmaniasis represents an additional obstacle. Although niosomes and combination therapies have been suggested as potential approaches to address the issue of antibiotic resistance exhibited by biofilm-forming bacteria and drug-resistant MT , PA , and SA , respectively, the effectiveness of these treatments is still being studied.…”

Section: Treatment Of Infectionsmentioning

confidence: 99%

Composition, preparation methods, and applications of nanoniosomes as codelivery systems: a review of emerging therapies with emphasis on cancer

Roostaee,

Derakhshani,

Mirhosseini

et al. 2024

Nanoscale

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“…82 , 83 , 84 If these alternate models were already flawless, then why do we still have the antibiotic crisis or a lack of affordable drugs for Alzheimer's disease? 59 , 85 , 86 , 87 , 88 With such imperfect systems, untested drugs identified using them will pose a risk to patients, with pregnant patients being particularly vulnerable. 89 , 90 Even if a child is born with defects, in contrast to countries where social healthcare system and infrastructure are designed to support people with disabilities, the children most affected will be those in countries lacking such resources.…”

Section: Implications Of Animal Model Alternatives For Developing Nat...mentioning

confidence: 99%

“Blind men and an elephant”: The need for animals in research, drug safety studies, and understanding civilizational diseases

Anbalagan

2023

Anim Models and Exp Med

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Animal‐based research and drug safety studies are essential to understanding the mysteries of nature and the long‐term survival of humans. Due to the rapid increase in the global human population, conflict‐ and economically driven human migration, tourism‐related activities, densely populated metropolitan areas, and local policies, humans will be affected by a multitude of novel disease‐causing microorganisms and civilizational diseases. Despite disparities among countries, recent and planned changes in regulations concerning animal research and drug safety studies could have detrimental effects on both the animal research community and nations lacking sufficient social support systems. Based on existing scientific literature, I argue that we need animal research encompassing aspects such as animal development, behavior, drug safety studies, and for the understanding of future civilizational diseases. Depending on the nature of the research questions and local challenges, a suitable animal model organism should be made mandatory.

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Extrinsic Antibiotic-Resistant Mechanism in Bacteria

Cited by 5 publications

References 88 publications

Combined Effect of Isolated Bacteriophage and Neem Extract on Isolated Multiple Drug-Resistant Pathogenic Escherichia coli E1 From Well Water

Combined Effect of Isolated Bacteriophage and Neem Extract on Isolated Multiple Drug-Resistant Pathogenic Escherichia coli E1 From Well Water

Composition, preparation methods, and applications of nanoniosomes as codelivery systems: a review of emerging therapies with emphasis on cancer

“Blind men and an elephant”: The need for animals in research, drug safety studies, and understanding civilizational diseases

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