Extremely Rapid Growth of a Primary Choroidal Melanoma

Uveal melanoma: updated considerations on current management modalities

“…Information derived from this literature showed that the time intervals between dissemination and metastatic death were widely spread and varied between 3 and 30 years. Subsequently numerous reports on tumour doubling times in uveal melanomas have been provided [11][12][13][14]; in only three out of thirty-nine patients were the doubling times estimated to be shorter than 60 days.…”

Uveal melanoma: updated considerations on current management modalities

“…Information derived from this literature showed that the time intervals between dissemination and metastatic death were widely spread and varied between 3 and 30 years. Subsequently numerous reports on tumour doubling times in uveal melanomas have been provided [11][12][13][14]; in only three out of thirty-nine patients were the doubling times estimated to be shorter than 60 days.…”

Uveal melanoma: therapeutic consequences of doubling times and irradiation results; a review

“…Since then, 39 calculated Td's of uveal melanomas have been published (Table 1). The first report [25] concerns 1Td, calculated as being 17 days; this has remained the shortest uveal melanoma Td ever published. Two following reports [3,29] concern 19 and 18 Td's respectively, which range from 22.6 to 540 days [3] and from 2 to 135 months [29].…”

Mortality after deferral of treatment or no treatment for choroidal melanoma

“…Mortality coding, similar 5-year mortality for treated and not treated medium melanoma, and calculations of tumor doubling time suggest that metastatic dissemination may occur at an early stage of choroidal melanoma. [ 27 28 29 30 31 ] If metastasis has occurred, ocular treatment will control the ocular tumor but have no effect on the growth of metastatic tumors or long-term survival.…”

Uveal melanoma: updated considerations on current management modalities

“…Information derived from this literature showed that the time intervals between dissemination and metastatic death were widely spread and varied between 3 and 30 years. Subsequently numerous reports on tumour doubling times in uveal melanomas have been provided [11][12][13][14]; in only three out of thirty-nine patients were the doubling times estimated to be shorter than 60 days.…”

Uveal melanoma: therapeutic consequences of doubling times and irradiation results; a review

“…Since then, 39 calculated Td's of uveal melanomas have been published (Table 1). The first report [25] concerns 1Td, calculated as being 17 days; this has remained the shortest uveal melanoma Td ever published. Two following reports [3,29] concern 19 and 18 Td's respectively, which range from 22.6 to 540 days [3] and from 2 to 135 months [29].…”

Mortality after deferral of treatment or no treatment for choroidal melanoma

“…Mortality coding, similar 5-year mortality for treated and not treated medium melanoma, and calculations of tumor doubling time suggest that metastatic dissemination may occur at an early stage of choroidal melanoma. [ 27 28 29 30 31 ] If metastasis has occurred, ocular treatment will control the ocular tumor but have no effect on the growth of metastatic tumors or long-term survival.…”

Uveal melanoma: updated considerations on current management modalities

“…Information derived from this literature showed that the time intervals between dissemination and metastatic death were widely spread and varied between 3 and 30 years. Subsequently numerous reports on tumour doubling times in uveal melanomas have been provided [11][12][13][14]; in only three out of thirty-nine patients were the doubling times estimated to be shorter than 60 days.…”

Uveal melanoma: therapeutic consequences of doubling times and irradiation results; a review

“…Since then, 39 calculated Td's of uveal melanomas have been published (Table 1). The first report [25] concerns 1Td, calculated as being 17 days; this has remained the shortest uveal melanoma Td ever published. Two following reports [3,29] concern 19 and 18 Td's respectively, which range from 22.6 to 540 days [3] and from 2 to 135 months [29].…”

Mortality after deferral of treatment or no treatment for choroidal melanoma

“…Mortality coding, similar 5-year mortality for treated and not treated medium melanoma, and calculations of tumor doubling time suggest that metastatic dissemination may occur at an early stage of choroidal melanoma. [ 27 28 29 30 31 ] If metastasis has occurred, ocular treatment will control the ocular tumor but have no effect on the growth of metastatic tumors or long-term survival.…”