Extreme population‐level events: Do they have an impact on cancer?

Thompson, Beti; Gehlert, Sarah; Paskett, Electra D.

doi:10.1002/cncr.30778

Cited by 2 publications

(2 citation statements)

References 25 publications

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“…Previous studies suggest that extreme population-level events, such as war or famine, may have an impact on cancer incidence. 32 An analysis among Norwegian women in 2002 demonstrated a decreased incidence of breast cancer during World War II, lending to the suggestion that caloric restriction is protective against some cancers. 33 Social unrest during the occupied period limited the access to fat, meat, or milk, leading to a substantial reduction in food availability and energy intake, which in turn was associated with a decreased cohort effect for the generation born between 1930 and 1950.…”

Section: Discussionmentioning

confidence: 99%

Disparities of birth cohort effects on pancreatic cancer incidence between the United States and urban China

et al. 2021

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Background: Pancreatic cancer has been associated with lifestyle factors, but few comparative studies were conducted among countries of different culture and lifestyle habits. This study compared the trends of pancreatic cancer incidence and birth cohort effects in the United States and urban China and explored the potential discrepancies of risk patterns. Materials and methods: Age-standardized incidence rates (ASIRs) were calculated using data from national or regional cancer registries of the United States and two large cities of China (Shanghai, Hong Kong). The temporal trends of incidence were assessed by joinpoint regression. The effects of birth cohort and calendar period were identified through ageeperiodecohort modeling.Results: The ASIR in the United States from 1976 to 2015 was 8.26/100 000, which was higher than that in Hong Kong (4.29/100 000) and Shanghai of China (6.63/100 000). Shanghai had lower incidence (4.41/100 000) in 1976-1980 but increased annually by 1.38% in males and 1.67% in females, with a sharper upward trend than the United States and Hong Kong. Males had higher risks than females, with a male-to-female ratio of 1.34, 1.44, and 1.37 in the United States, Hong Kong, and Shanghai, respectively. A significant and prominent increase in incidence rate was observed among successive generations in China particularly for Shanghai, but such a pattern was not apparent in the United States. Conclusions: The differences in pancreatic cancer incidence by sex may be multi-factorial involving known risk factors like tobacco smoking and alcohol consumption. The significant birth cohort effects among recent and early generations in the Shanghai population were in line with a society in socioeconomic transition and adoption of Western lifestyle mainly including consumption of calorie-rich foods and physical inactivity. Differences in these risk patterns will have implications on health care efforts and policies for cancer control.

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Section: Discussionmentioning

confidence: 99%

Disparities of birth cohort effects on pancreatic cancer incidence between the United States and urban China

et al. 2021

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“…Early on, the research team established a theoretical framework to ensure alignment across TCC initiatives. The framework was guided by an emerging hypothesis about the contribution of psychosocial and social stressors to racial disparities in health outcomes; recent conceptual models indicate that these stressors impact biological processes that play a role in the initiation and progression of the disease ( Gehlert et al, 2008 ; Thompson et al, 2017 ). Allostatic load (AL) is an indicator of biological dysregulation in response to psychological and social stress.…”

Section: Overview Of Musc Tcc In Precision Medicine and Minority Men’mentioning

confidence: 99%

Lessons Learned from the Medical University of South Carolina Transdisciplinary Collaborative Center (TCC) in Precision Medicine and Minority Men’s Health

et al. 2020

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The Transdisciplinary Collaborative Center (TCC) in Precision Medicine for Minority Men’s Health was established at the Medical University of South Carolina (MUSC) in 2015 to address disparities in the translation of precision medicine approaches among racial minority groups. This regional consortium focuses on three primary areas: (1) the development of a consortium of regional and national partners, (2) conducting transdisciplinary research examining synergistic effects of biological, social, physiological, and clinical determinants of chronic disease risks and outcomes, and (3) dissemination and implementation of precision medicine approaches, with an emphasis on reducing disparities in health care and outcomes among minority men. Given consistent calls to better translate precision medicine approaches and the focus of this consortium on addressing disparities among minority men, we provide an overview of our experience in developing the MUSC TCC, including barriers and facilitators to conducting translational research on minority men’s health issues in the context of precision medicine. Lessons learned and areas for improvement include providing enough time to create consistent partnerships and community engagement to improve recruitment and retention, identifying unique ways to engage diverse partners from across the region and nation, and better approaches to dissemination and communication for large partnerships focusing on precision medicine.

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Extreme population‐level events: Do they have an impact on cancer?

Cited by 2 publications

References 25 publications

Disparities of birth cohort effects on pancreatic cancer incidence between the United States and urban China

Disparities of birth cohort effects on pancreatic cancer incidence between the United States and urban China

Lessons Learned from the Medical University of South Carolina Transdisciplinary Collaborative Center (TCC) in Precision Medicine and Minority Men’s Health

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