Extrapulmonary Small Cell Carcinoma: Multimodality Treatment Results

Şengöz, Meriç; Abacıoğlu, Ufuk; Salepçi, Taflan; Eren, Funda; Yumuk, F.; Turhal, Serdar

doi:10.1177/030089160308900308

Cited by 65 publications

(47 citation statements)

References 28 publications

(4 reference statements)

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“…Female gender, a favorable prognostic factor not mentioned in previously published studies, may partly be attributable to tumors of gynecologic origin, which were often associated with a better outcome than tumors of other origins [12, 15]. Several groups of investigators have pointed out that limited disease is the most sensitive predictor of better survival [15,16,17]. Further, Sevin et al[ 18] reported that combined modality treatment provided the best chance of survival in patients with EPSCC of gynecologic origin [18].…”

Section: Discussionmentioning

confidence: 99%

“…All six studies reported a predominance of patients with limited disease. The distribution of the cancer origin varied, but gastrointestinal origin seemed to be the most common site and associated with the worst prognosis in five of the six studies [1, 11, 12, 15, 17]. Because these studies differed in sample sizes and were retrospective in design, survival outcome was hard to compare.…”

Section: Discussionmentioning

confidence: 99%

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Prognostic Factors in Extrapulmonary Small Cell Carcinomas

Lin¹,

Chung

Chang

et al. 2007

Oncology

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Background: Extrapulmonary small cell carcinoma (EPSCC) is a heterogeneous group of cancers. The clinicopathological features of EPSCC remain poorly defined. Patients and Methods: Patients with the clinicopathological features of EPSCC, treated at three major medical centers in Taiwan, were included. Histologic and clinical diagnoses, smoking history, staging, clinical course and treatment outcome were reviewed and analyzed. Results: A total of 90 patients, treated between 1995 and 2005, were eligible for analysis. Forty-nine patients had limited disease and 41 extensive disease. Ten, 18, 17 and 45 patients received no treatment, local treatment, chemotherapy alone or combined modality treatment, respectively; the median survival for these four groups was 1.1, 13.8, 6.7 and 24.9 months. The origin of cancer was head and neck in 17, gastrointestinal in 27, genitourinary in 10, gynecologic in 27 and unknown in 9 patients; the median survival time was 34.2, 6.4, 9.1, 23.7 and 9.2 months, respectively. Ten out of 90 patients were long-term survivors, and 9 of them had tumors of head-and-neck and gynecologic origin. There was no statistically significant difference in survival between smokers and non-smokers. Factors associated with survival in univariate analysis included age ≤60, female gender, limited disease, head-and-neck and gynecologic origin, as well as combined modality treatment. However, in multivariate analysis, only female gender, limited disease and combined modality treatment were independent predictors of survival. Conclusions: Female gender, limited disease and combined modality treatment are favorable prognostic factors for patients with EPSCC. Prolonged survival is more likely in patients with tumors of head-and-neck and gynecologic origin.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prognostic Factors in Extrapulmonary Small Cell Carcinomas

Lin¹,

Chung

Chang

et al. 2007

Oncology

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“…Very few cases have been reported till date [3,4,[5][6][7][8][9][10][11][12][13][14][15]. Neuroendocrine tumors arise from embryonic neural crest cells that migrate to bronchopulmonary or gastrointestinal tract during development.…”

Section: Discussionmentioning

confidence: 99%

“…The clinical progression was rapid, and death occurred within five months after diagnosis. Sengoz et al [9] reported two cases; one patient received chemotherapy whereas hemihepatectomy was performed on another. The survival of the patients was 13 and 67 months respectively.…”

Section: Discussionmentioning

confidence: 99%

Primary Small Cell Carcinoma of Liver in a HIV/Hepatitis B Co-Infected Patient on Virologically Suppressive Antiretroviral Therapy: Case Report and Literature Review

Dravid¹,

Natarajan²,

Medisetty³

et al. 2017

Oncology and cancer case reports

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“…[12] Şengöz ve ark. [14] retrospektif olarak değer-lendirdikleri 16 ekstrapulmoner yerleşimli hastalarda 2 ve 5 yıllık sağkalımları sırasıyla %41 ve %11 olarak bildirmişlerdir. Ortalama sağkalım ise 14 ay olarak bildirilmiştir.…”

Section: Discussionunclassified