Extramedullary hematopoiesis occurring in a hemangioma of the skin

Green, L. K.

doi:10.1001/archderm.124.11.1720

Cited by 7 publications

(7 citation statements)

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“…Most often it is associated with hematologic disorders, both neoplastic (e.g., myelofibrosis and the spent phase of polycythemia vera [5]) and non-neoplastic (as in thalassemias [6]). It has also been described in association with some tumors, including cerebellar hemangioblastomas (7), hemangiomas (8), hepatoblastomas (9), leiomyomas (10), pilomatricomas (11), hepatic angiosarcoma (12), endometrial carcinoma (13), meningioma (14), hepatic adenoma (15), mesoblastic nephroma (16), liposarcoma (17), myofibroblastic tumors and renal cell carcinomas, and in a variety of non-neoplastic environments such as allograft livers (18,19), acute tubular necrosis (20), breast biopsy cavities (21), endometrial stroma (14), congenital viral infections (22), and a myocardial infarct (23). The pathophysiology of EMH in cases not associated with hematologic disorders seems to be different from EMH in myelofibrosis and the spent phase of polycythemia vera.…”

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confidence: 99%

Myocardial Extramedullary Hematopoiesis: A Clinicopathologic Study

Hill

Swanson

2000

Modern Pathology

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Extramedullary hematopoiesis (EMH) after fetal development is uncommon and is most often seen in patients who have hematologic disorders. EMH unassociated with hematologic disease is rare. After the recent observation of EMH in a myocardial infarct, we sought to determine the frequency and clinicopathologic setting of EMH in myocardial tissues submitted for pathologic examination. Hematoxylin and eosin (H&E)-stained sections from 805 consecutive myocardial samples (207 surgical specimens, 598 autopsy specimens) were examined retrospectively. The presence of immature erythroid or myeloid cell clusters in intramyocardial capillaries or stroma was considered sufficient for the diagnosis of EMH. Immunoperoxidase studies confirming the nature of the hematopoietic cell infiltrate were performed in selected cases. Foci of EMH (often multiple) were identified in 15 of 207 surgical hearts (7.2%) and in 22 of 598 autopsy hearts (3.7%). Patient ages (exclusive of premature infants) ranged from 2 weeks to 73 years (median, 13 years). Twenty-four of 37 (65%) EMH-positive cases were associated with infarcts in various stages of repair (accounting for 11 of 68 [16.2%] of all infarcts in surgical specimens and 13 of 86 [15.1%] of infarcts in autopsy specimens). Acute infarcts less than 72 hours old, excluding those with acute extension, were not associated with EMH. Viral myocarditis and myocardial hypertrophy with fibrosis accounted for primary diagnoses in the nonischemic, EMH-positive surgical cases, whereas seven of nine nonischemic, EMH-positive autopsy cases involved premature or term infants with no obvious myocardial disease. Another autopsy patient had sarcoidosis with myelophthisic involvement of her bone marrow and represented one of only two cases overall in which a hematopoietic disorder was coexistent or suspected. Myocardial EMH is relatively common after myocardial infarct but is rarely encountered in normal or nonischemic myocardium. Its presence in healing but not early acute stages of infarct suggests that EMH results from inflammation-or repair-associated trophic factors, not from ischemia itself.

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confidence: 99%

Myocardial Extramedullary Hematopoiesis: A Clinicopathologic Study

Hill

Swanson

2000

Modern Pathology

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“…The purple lesions of dermal hematopoiesis were observed only in close relationship to the hemangiomas. .\ previous report (18) describes cxtramedullary bematopoiesis in the lumen of the vessels of a cutaneous hemangioma in an adult patient with myelofibrosis following splenectomy. However, in our case the hematopoietic cells were ob.served in the stroma between the vessels and no splenectomy had been performed.…”

Section: Discussionmentioning

confidence: 96%

“…One hypothesis suggests local factors in the microenvironment may affect the pathogenesis of neonatal hematopoiesis (3,18). Hematopoiesis is a complex process requiring, in addition to the stem cells, the existence of an hematopoietic environment which includes fibrobiasts, endothelia!…”

Section: Discussionmentioning

confidence: 99%

Neonatal Dermal Hematopoiesis Associated with Diffuse Neonatal Hemangiomatosis

Évole‐Buselli

Hernandez-Marti

Gascó-Lacalle

et al. 1997

Pediatric Dermatology

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This report describes a neonate with dermal hematopoiesis associated with diffuse hemangiomatosis. The cutaneous lesions consisted of multiple red papules and bluish subcutaneous nodules scattered over his body. The nodules were bluish due to the presence of hematopoietic tissue within the hemangiomas. Although neonatal dermal hematopoiesis has been described with viral infections or hematologic dyscrasias, the association with diffuse hemangiomatosis has not been previously described.

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“…This is the first report showing EMH in cord hemangioma. There are several reports of EMH in hemangiomas arising from other adult organs, including kidney [ 16 – 19 ], skin [ 19 – 21 ], spleen [ 22 ], small bowel [ 23 ], and adrenal gland [ 24 ]. Some of these reports suggested that hemangioma can potentially generate hematopoietic precursor cells [ 20 , 21 ], based on a study showing that the common precursor cell differentiated into both vascular endothelial and hematopoietic cells [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

A giant cord hemangioma with extramedullary hematopoiesis and elevated maternal serum human chorionic gonadotropin: a case report and review of the literature

et al. 2015

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A case of prenatally diagnosed, giant cord hemangioma is reported, which was accompanied by the elevation of maternal serum alpha-fetoprotein (MS-AFP) and human chorionic gonadotropin (MS-hCG) levels. A 30-year-old woman without a previous history of gravida or para, presented with intermittent abdominal pain at 26 weeks of gestation. Doppler studies showed the fetus developing heart failure as the tumor grew larger. Caesarian section was performed at 29 weeks of gestation. Macroscopic examination of the placenta revealed a 17.0 × 10.0 × 7.0 cm tumor localized at the placental end of the umbilical cord. Microscopically, the tumor was composed of small arborizing vessels proliferating in the myxoid background, and the tumor cells were positive for AFP by immunohistochemistry. Extramedullary hematopoiesis was seen in the tumor vascular channels. The present case is one of the largest umbilical cord hemangiomas reported in the literature, and the first hemangioma case with MS-hCG elevation, extramedullary hematopoiesis, and positive AFP staining in the cord hemangioma. Its clinical course and detailed pathological findings are presented along with a review of the related literature.

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Extramedullary hematopoiesis occurring in a hemangioma of the skin

Cited by 7 publications

References 0 publications

Myocardial Extramedullary Hematopoiesis: A Clinicopathologic Study

Myocardial Extramedullary Hematopoiesis: A Clinicopathologic Study

Neonatal Dermal Hematopoiesis Associated with Diffuse Neonatal Hemangiomatosis

A giant cord hemangioma with extramedullary hematopoiesis and elevated maternal serum human chorionic gonadotropin: a case report and review of the literature

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