2010
DOI: 10.3109/13880200903490513
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Extraction and phytochemical investigation ofCalotropis procera: Effect of plant extracts on the activity of diverse muscles

Abstract: The present data on the extracts of C. procera indicate a direct action on the myocardium, stimulatory effect on smooth muscle motility, and relaxant action on skeletal muscle contraction. Chemical constituents could directly affect the cell membrane probably through receptors coupling to G proteins. They regulate the ion channel physiology as in the myocardium.

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Cited by 57 publications
(33 citation statements)
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References 25 publications
(24 reference statements)
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“…In this study, aqueous extract of C. procera is reported to possess several classes of phytochemicals. These results are in agreement with the previous studies where C. procera leaves extracts have been reported to possess glycosides, tannins, phenolics, terpenoids, cardenolides, flavonoids and saponins as major phytochemicals (Murti et al, 2010;Moustafa et al, 2010).…”
Section: Discussionsupporting
confidence: 94%
“…In this study, aqueous extract of C. procera is reported to possess several classes of phytochemicals. These results are in agreement with the previous studies where C. procera leaves extracts have been reported to possess glycosides, tannins, phenolics, terpenoids, cardenolides, flavonoids and saponins as major phytochemicals (Murti et al, 2010;Moustafa et al, 2010).…”
Section: Discussionsupporting
confidence: 94%
“…Phytochemical analysis on the genus Ficus displayed the presence of flavonoids (Mohammad, Sutradhar, Ahmad, & Rnjit 1991), alkaloids (Ikhlas, Rali, & Stigher, 1993), organic acids (Ilyas, 1990) and triterpenes (Beat, Clemens, Wright, Rali, & Otto, 1990 Tanins were present in all oils and latices while terpenes were absent in Calotropis and Ficus latex (Table 3). The phytochemical investigation of Calotropis procera indicated the presence of cardenolides, flavonoids, and saponins (Moustafa, Ahmed, Nabil, Hussein, & Omran, 2010). Number of investigators has reported the efficacy of these phytochemicals having antiviral potential (Du, He, & Jiang, 2003;Wei, C. Ma, & Y. Ma, 2004).…”
Section: Discussionmentioning
confidence: 99%
“…Thus, since muscle-type nicotinic acetylcholine receptors play an important role for skeletal and respiration-related muscle contraction and relaxation, these receptors are one of main targets of drugs and toxins. In previous reports, flavonoids derived from plants or tea extracts were demonstrated to affect acetylcholine release, muscle contraction and neuromuscular junction activity [14][15][16][17][18]. However, relatively little is known how flavonoids including quercetin regulate muscle-type nicotinic acetylcholine receptor channel activity.…”
Section: Non-competitive Inhibition Of α1β1δε Nicotinic Acetylcholinementioning
confidence: 99%
“…1). Flavonoids derived from plants or tea extracts affect acetylcholine release, muscle contraction or neuromuscular junction activity [14][15][16][17][18]. Especially, quercetin inhibits end-plate currents at the mouse neuromuscular junction [19].…”
Section: Introductionmentioning
confidence: 99%