Extraction and phytochemical investigation ofCalotropis procera: Effect of plant extracts on the activity of diverse muscles

Moustafa, Amal M. Youssef; Ahmed, Safwat; Nabil, Zohour I.; Hussein, Aida A.; Omran, Mohamed A.

doi:10.3109/13880200903490513

Cited by 57 publications

(33 citation statements)

References 25 publications

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“…In this study, aqueous extract of C. procera is reported to possess several classes of phytochemicals. These results are in agreement with the previous studies where C. procera leaves extracts have been reported to possess glycosides, tannins, phenolics, terpenoids, cardenolides, flavonoids and saponins as major phytochemicals (Murti et al, 2010;Moustafa et al, 2010).…”

Section: Discussionsupporting

confidence: 94%

Phytochemical composition, mosquito larvicidal, ovicidal and repellent activity of Calotropis procera against Culex tritaeniorhynchus and Culex gelidus

Kumar

Karthik

Rao

et al. 2012

Bangladesh J Pharmacol

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Section: Discussionsupporting

confidence: 94%

Phytochemical composition, mosquito larvicidal, ovicidal and repellent activity of Calotropis procera against Culex tritaeniorhynchus and Culex gelidus

Kumar

Karthik

Rao

et al. 2012

Bangladesh J Pharmacol

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“…Phytochemical analysis on the genus Ficus displayed the presence of flavonoids (Mohammad, Sutradhar, Ahmad, & Rnjit 1991), alkaloids (Ikhlas, Rali, & Stigher, 1993), organic acids (Ilyas, 1990) and triterpenes (Beat, Clemens, Wright, Rali, & Otto, 1990 Tanins were present in all oils and latices while terpenes were absent in Calotropis and Ficus latex (Table 3). The phytochemical investigation of Calotropis procera indicated the presence of cardenolides, flavonoids, and saponins (Moustafa, Ahmed, Nabil, Hussein, & Omran, 2010). Number of investigators has reported the efficacy of these phytochemicals having antiviral potential (Du, He, & Jiang, 2003;Wei, C. Ma, & Y. Ma, 2004).…”

Section: Discussionmentioning

confidence: 99%

Essential Oils and Latices as Novel Antiviral Agent Against Potato Leaf Roll Virus and Analysis of Their Phytochemical Constituents Responsible for Antiviral Activity

Iftikhar¹,

Shahid²,

Javed³

et al. 2013

JAS

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The present work was aimed to limit the practice of using pesticides in the managing program of the potato leaf roll disease on potato plants as the misuse of some pesticides had caused severe problems. The study was focused to find compounds nontoxic and safe for the biome. The antiviral activity of essential oils and latices tapped from different plants was investigated against potato leaf roll virus (PLRV). Essential oils from Eucalyptus citriodora leaves, Clove buds, and Fennel seeds were extracted. Latex of Aloe vera, Calotropis procera and Ficus elastic were collected. Essential oil and latex spray solutions were prepared at 5 and 10% concentration. All the sprayings were done at 7 days interval. Inhibition of viral replication was monitored by amplification of PLRV capsid protein gene and mRNA expression using RT-PCR technique. Results depicted inhibitory potential of all the tested essential oils and latices against PLRV infestation and also the effect was found concentration dependent. Our data showed that Aloe vera latex and clove essential oil caused maximum inhibition viral mRNA at 10% concentration. Qualitatively analyzed Tannin, Phlobactanins, Saponin, Flavonoids, Sterols and Terpens from essential oils and latices gave positive results in most of the oils and lesser content in plant latices. In the GC-MS analysis, high contents of some bioactive phytochemical compounds identified were Eugenol in Clove buds, Eucalyptol, D-Limonene and L-Limonene both in Eucalyptus leaves and Fennel seed oils and Fenchone in Fennel seeds. As this research work illustrates, there is innumerable potential of plants essential oils/latex waiting to be evaluated and exploited against genetically and functionally diverse plant viruses.

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“…Thus, since muscle-type nicotinic acetylcholine receptors play an important role for skeletal and respiration-related muscle contraction and relaxation, these receptors are one of main targets of drugs and toxins. In previous reports, flavonoids derived from plants or tea extracts were demonstrated to affect acetylcholine release, muscle contraction and neuromuscular junction activity [14][15][16][17][18]. However, relatively little is known how flavonoids including quercetin regulate muscle-type nicotinic acetylcholine receptor channel activity.…”

Section: Non-competitive Inhibition Of α1β1δε Nicotinic Acetylcholinementioning

confidence: 99%

“…1). Flavonoids derived from plants or tea extracts affect acetylcholine release, muscle contraction or neuromuscular junction activity [14][15][16][17][18]. Especially, quercetin inhibits end-plate currents at the mouse neuromuscular junction [19].…”

Section: Introductionmentioning

confidence: 99%

Inhibitory Effects of Quercetin on Muscle-type of Nicotinic Acetylcholine Receptor-Mediated Ion Currents Expressed in Xenopus Oocytes

Lee

Shin

Hwang

et al. 2011

Korean J Physiol Pharmacol

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The flavonoid quercetin is a low molecular weight compound generally found in apple, gingko, tomato, onion and other red-colored fruits and vegetables. Like other flavonoids, quercetin has diverse pharmacological actions. However, relatively little is known about the influence of quercetin effects in the regulation of ligand-gated ion channels. Previously, we reported that quercetin regulates subsets of nicotinic acetylcholine receptors such as α 3β 4, α 7 and α 9α 10. Presently, we investigated the effects of quercetin on muscle-type of nicotinic acetylcholine receptor channel activity expressed in Xenopus oocytes after injection of cRNA encoding human fetal or adult muscle-type of nicotinic acetylcholine receptor subunits. Acetylcholine treatment elicited an inward peak current (IACh) in oocytes expressing both muscle-type of nicotinic acetylcholine receptors and co-treatment of quercetin with acetylcholine inhibited IACh. Pre-treatment of quercetin further inhibited IACh in oocytes expressing adult and fetal muscle-type nicotinic acetylcholine receptors. The inhibition of IACh by quercetin was reversible and concentration-dependent. The IC50 of quercetin was 18.9±1.2μM in oocytes expressing adult muscle-type nicotinic acetylcholine receptor. The inhibition of IACh by quercetin was voltageindependent and non-competitive. These results indicate that quercetin might regulate human muscletype nicotinic acetylcholine receptor channel activity and that quercetin-mediated regulation of muscle-type nicotinic acetylcholine receptor might be coupled to regulation of neuromuscular junction activity.

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Extraction and phytochemical investigation ofCalotropis procera: Effect of plant extracts on the activity of diverse muscles

Cited by 57 publications

References 25 publications

Phytochemical composition, mosquito larvicidal, ovicidal and repellent activity of <i>Calotropis procera </i> against <i>Culex tritaeniorhynchus</i> and <i>Culex gelidus</i>

Phytochemical composition, mosquito larvicidal, ovicidal and repellent activity of <i>Calotropis procera </i> against <i>Culex tritaeniorhynchus</i> and <i>Culex gelidus</i>

Essential Oils and Latices as Novel Antiviral Agent Against Potato Leaf Roll Virus and Analysis of Their Phytochemical Constituents Responsible for Antiviral Activity

Inhibitory Effects of Quercetin on Muscle-type of Nicotinic Acetylcholine Receptor-Mediated Ion Currents Expressed in Xenopus Oocytes

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