Extracranial carotid arteries: evaluation with "black blood" MR angiography.

Edelman, Robert R.; Mattle, Heinrich; Wallner, Bernd; Bajakian, Richard L.; Kleefield, Jonathan; Kent, K. Craig; Skillman, John J.; Mendel, Jeffrey B.; Atkinson, D

doi:10.1148/radiology.177.1.2399337

Cited by 145 publications

(64 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Technically, black blood imaging of the vessel wall is usually performed using fast sequences, utilizing multiple spin echoes for signal acquisition [different manufacturers use specific names for these sequences, such as fast spin-echo (FSE), turbo spin-echo (TSE), rapid acquisition with relaxation enhancement (RARE)] and a preparative module for blood signal suppression (34). Black blood imaging is currently based on two wellknown techniques: in-flow saturation (35) and double inversion-recovery (DIR) (36). The method of in-flow saturation usually does not allow for complete elimination of the signal from blood and may be ineffective in the presence of complicated flow patterns (recirculation and variable velocity components), such as those observed in the carotid bifurcation.…”

Section: Imaging Pulse Sequencesmentioning

confidence: 99%

MRI of atherosclerosis in clinical trials

et al. 2006

View full text Add to dashboard Cite

Magnetic resonance imaging (MRI) of the arterial wall has emerged as a viable technology for characterizing atherosclerotic lesions in vivo, especially within carotid arteries and other large vessels. This capability has facilitated the use of carotid MRI in clinical trials to evaluate therapeutic effects on atherosclerotic lesions themselves. MRI is specifically able to characterize three important aspects of the lesion: size, composition and biological activity. Lesion size, expressed as a total wall volume, may be more sensitive than maximal vessel narrowing (stenosis) as a measure of therapeutic effects, as it reflects changes along the entire length of the lesion and accounts for vessel remodeling. Lesion composition (e.g. lipid, fibrous and calcified content) may reflect therapeutic effects that do not alter lesion size or stenosis, but cause a transition from a vulnerable plaque composition to a more stable one. Biological activity, most notably inflammation, is an emerging target for imaging that is thought to destabilize plaque and which may be a systemic marker of vulnerability. The ability of MRI to characterize each of these features in carotid atherosclerotic lesions gives it the potential, under certain circumstances, to replace traditional trials involving large numbers of subjects and hard end-points -heart attacks and strokes -with smaller, shorter trials involving imaging end-points. In this review, the state of the art in MRI of atherosclerosis is presented in terms of hardware, image acquisition protocols and post-processing. Also, the results of validation studies for measuring lesion size, composition and inflammation will be summarized. Finally, the status of several clinical trials involving MRI of atherosclerosis will be reviewed.

show abstract

Section: Imaging Pulse Sequencesmentioning

confidence: 99%

MRI of atherosclerosis in clinical trials

et al. 2006

View full text Add to dashboard Cite

show abstract

“…If blood flows out of the plane of the section in the time interval between successive RF pulses, the result is an absence of signal, called a flow void. 1 The flow void can be emphasized by use of a thin section or a long echo time. In a fast spin-echo sequence, a long train of echoes is acquired by use of a series of 180 o RF pulses; as a result, washout effects are even more substantial than with conventional spin-echo techniques.…”

Section: Mra: Technical Considerationsmentioning

confidence: 99%

Magnetic Resonance Angiography

Yucel¹,

Anderson²,

Edelman³

et al. 1999

Circulation

125

View full text Add to dashboard Cite

“…17,18 Therefore, by combining BB-MR with high-spatialresolution and fast-data-acquisition imaging, both lumen and wall imaging of the coronary arteries should be possible. A number of different methods are available for BB-MR. [17][18][19][20][21] However, none of these methods have been used for coronary lumen and wall imaging.…”

mentioning

confidence: 99%

Noninvasive In Vivo Human Coronary Artery Lumen and Wall Imaging Using Black-Blood Magnetic Resonance Imaging

et al. 2000

View full text Add to dashboard Cite

Background-High-resolution MRI has the potential to noninvasively image the human coronary artery wall and define the degree and nature of coronary artery disease. Coronary artery imaging by MR has been limited by artifacts related to blood flow and motion and by low spatial resolution. Methods and Results-We used a noninvasive black-blood (BB) MRI (BB-MR) method, free of motion and blood-flow artifacts, for high-resolution (down to 0.46 mm in-plane resolution and 3-mm slice thickness) imaging of the coronary artery lumen and wall. In vivo BB-MR of both normal and atherosclerotic human coronary arteries was performed in 13 subjects: 8 normal subjects and 5 patients with coronary artery disease. The average coronary wall thickness for each cross-sectional image was 0.75Ϯ0.17 mm (range, 0.55 to 1.0 mm) in the normal subjects. MR images of coronary arteries in patients with Ն40% stenosis as assessed by x-ray angiography showed localized wall thickness of 4.38Ϯ0.71 mm (range, 3.30 to 5.73 mm). The difference in maximum wall thickness between the normal subjects and patients was statistically significant (PϽ0.0001). Conclusions-In

show abstract

Extracranial carotid arteries: evaluation with "black blood" MR angiography.

Cited by 145 publications

References 14 publications

MRI of atherosclerosis in clinical trials

MRI of atherosclerosis in clinical trials

Magnetic Resonance Angiography

Noninvasive In Vivo Human Coronary Artery Lumen and Wall Imaging Using Black-Blood Magnetic Resonance Imaging

Contact Info

Product

Resources

About