2018
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Abstract: Aims: The acute respiratory distress syndrome (ARDS) is a frequent condition following pneumonia in immunocompromised cancer patients. Extracorporeal membrane oxygenation (ECMO) may serve as a rescue therapy in refractory ARDS but has still not been studied in predominantly leuco- and thrombocytopenic cancer patients. Patients and Methods: In this monocentric, retrospective, observational study, we assessed all cancer patients treated with ECMO for ARDS between 2013 and 2017. Results: 25 patients, 11 of whom u… Show more

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Cited by 11 publications
(15 citation statements)
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References 27 publications
(34 reference statements)
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“…13,14 The eight patients after HSCT represented a complications. 24,[35][36][37] The underlying disease and sequelae of treatment can predispose patients with oncologic disease and/or HSCT to all these complications: bleeding and clotting due to thrombocytopenia and impaired hepatic function [38][39][40] ; infectious complications due to neutropenia, lymphopenia and immunosuppressive medications 36,41 ; fluid overload and acute kidney injury due to renal impairment 41,42 ; and respiratory compromise due to pulmonary dysfunction. 10,30,31 Whether bleeding complications in oncologic and/or HSCT patients on ECMO are more frequent is still controversial.…”
Section: Discussionmentioning
confidence: 99%
“…13,14 The eight patients after HSCT represented a complications. 24,[35][36][37] The underlying disease and sequelae of treatment can predispose patients with oncologic disease and/or HSCT to all these complications: bleeding and clotting due to thrombocytopenia and impaired hepatic function [38][39][40] ; infectious complications due to neutropenia, lymphopenia and immunosuppressive medications 36,41 ; fluid overload and acute kidney injury due to renal impairment 41,42 ; and respiratory compromise due to pulmonary dysfunction. 10,30,31 Whether bleeding complications in oncologic and/or HSCT patients on ECMO are more frequent is still controversial.…”
Section: Discussionmentioning
confidence: 99%
“…The data on adult cancer patients receiving ECMO support are very limited [33]. Hemorrhagic complications, infection, immunosuppression, stroke, and thromboembolic complications have made the use of venovenous ECMO and venoarterial ECMO in patients with diverse malignancies less frequent [34].…”
Section: Discussion/conclusionmentioning
confidence: 99%
“…It is well known that prolonged use of ECMO support increases the risk of morbidity, mostly due to thrombotic and hemorrhagic complications [35]. Allogeneic stem cell transplantation presents a negative prognostic impact especially on survival of ECMO support whereas severe leuko- and thrombocytopenia is not a contraindication for ECMO support in general [33]. Nosocomial infections may even be triggered by impairment of cellular immunity, cytopenia, and chemotherapy and may dissuade clinicians from using ECMO support in these patients [36, 37].…”
Section: Discussion/conclusionmentioning
confidence: 99%
“…1 Given the improved survival of children with cancer, data suggest that ECMO can be considered in this population. [3][4][5][6][7][8][9][10][11][12][13] However, prolonged use (>28 days) of ECMO in children with refractory cardiac/respiratory failure has been associated with low survival and significant long-term neurologic and respiratory sequelae. 14,15 We report a 7-year-old boy with acute lymphoblastic lymphoma (ALL) who was admitted to the intensive care unit (ICU) with septic shock and candidemia.…”
Section: Prolonged Extracorporeal Membrane Oxygenation In Pediatric Leukemia With Severe Acute Respiratory Distress Syndrome and Persistementioning
confidence: 99%