Extracellular enzyme activities of dermatophytes and yeast isolates on solid media

Muhsin, Tawfik M.; Aubaid, Adnan H.; Al-Duboon, Abdul-Hafiz

doi:10.1111/j.1439-0507.1997.tb00186.x

Cited by 77 publications

(63 citation statements)

References 30 publications

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“…30 Once in the host tissue, dermatophytes or their metabolites induce an innate immune response by keratinocytes, thus activating immune response mechanisms or mediators. However, the immune response in dermatophytoses is scarcely known, involving unspecific mechanisms, as well as the development of a humoral and cellular response.…”

Section: Host-dermatophyte Interaction and The Pathogenesis Of Dermatmentioning

confidence: 99%

Dermatófitos: interação patógeno-hospedeiro e resistência a antifúngicos

Peres¹,

Maranhão²,

Rossi

et al. 2010

An. Bras. Dermatol.

156

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Cutaneous mycoses are among the most common infections in humans and have become an important public health issue because they cause invasive infections in immunocompromised patients. During the infectious process, dermatophyte-host interactions trigger specific metabolic adaptations that allow the pathogen to adhere to and penetrate the host tissue, scavenge nutrients, and overcome the host defense mechanisms. This metabolic shift and the interplay between metabolism, morphogenesis and stress response are important factors that have been extensively studied in several pathogens. Host cells also respond to the pathogen stimuli by activating intracellular signaling pathways that trigger the immune response against the infectious agent. The comprehension of the molecular aspects of these responses may help to establish new therapeutical strategies. In this review, different aspects of the biology of dermatophytes are addressed, with emphasis on the dermatophyte-host interaction and the mechanisms of antifungal resistance. Keywords: Antifungal agents; Dermatomycoses; Drug resistance, fungal; Host-pathogen interactions Resumo: As micoses cutâneas estão entre as infecções mais comuns em humanos e se tornaram um importante problema de saúde pública, principalmente por causarem infecções invasivas em pacientes imunodeprimidos. Durante a infecção, a interação dermatófito-hospedeiro desencadeia adaptações metabólicas específicas que permitem aos patógenos aderirem e penetrarem no tecido, remodelando seu metabolismo para captar nutrientes e superar os mecanismos de defesa do hospedeiro. Esse remodelamento metabólico e a inter-relação entre metabolismo, morfogênese e resposta ao estresse são importantes fatores que estão sendo intensamente avaliados em diversos patógenos. As células do hospedeiro também respondem aos estímulos do patógeno, ativando vias de sinalização intracelular que culminam no desencadeamento de uma resposta imune contra o agente infeccioso. O entendimento molecular dessas respostas metabólicas pode ajudar no estabelecimento de novas estratégias terapêuti-cas. Nesta revisão, são abordados diferentes aspectos da biologia dos dermatófitos, com ênfase na interação dermatófito-hospedeiro e nos mecanismos de resistência a antifúngicos.

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Section: Host-dermatophyte Interaction and The Pathogenesis Of Dermatmentioning

confidence: 99%

Dermatófitos: interação patógeno-hospedeiro e resistência a antifúngicos

Peres¹,

Maranhão²,

Rossi

et al. 2010

An. Bras. Dermatol.

156

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“…One of these, the alkylphosphocholine miltefosine (MI), is of particular interest because it is already licensed (Impavido; Aeterna Zentaris, Frankfurt, Germany) for the treatment of visceral leishmaniasis in many countries (28,29). Since dermatophytes also produce phospholipase(s) (3,15), we compared the in vitro activities of MI and two biscationic salts ( Fig. 1) against common dermatophytes with those of established antifungal agents by using the Clinical and Laboratory Standards Institute (CLSI) M38-A method (17) with recently determined optimal test conditions (7,24,25).…”

mentioning

confidence: 99%

In Vitro Activities of Miltefosine and Two Novel Antifungal Biscationic Salts against a Panel of 77 Dermatophytes

Tong

Widmer

Sorrell

et al. 2007

Antimicrob Agents Chemother

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“…Tween-80 opasite testi, T.rubrum ve T.mentagrophytes ayrımında kullanımı denenen ve opasitenin görülme zamanı üzerine odaklanmış bir testtir 19,20 . Lipid bileşikler hem T.mentagrophytes hem de T.rubrum tarafından enzim aktivitesiyle parçalanabilmekle birlikte, bu enzim aktivitesinin farklı türler ve/veya morfotipler arasında farklı olabileceği bildirilmiştir 21,22 . Zoosporik (veya slime) mantar olarak sınıflandırılan, ancak protista olduğu kabul edilen Thraustochytrium aureum ile laboratuvar koşullarında yapılan deneylerde, Tween-80 yapısında bulunan oleik asidin canlı hücre içine alınmasına lipazın etkisi olabileceği ileri sürülmüştür.…”

Section: Discussionunclassified