Extracellular Elastin Molecule Modulates Alzheimer’s Aβ Dynamics
            <i>In Vitro</i>
            and
            <i>In Vivo</i>
            by Affecting Microglial Activities

Li, Jingjing; Sun, Yao; Liang, Yingxia; Ma, Jun; Li, Bo; Ma, Chao; Tanzi, Rudolph E.; Zhang, Hongjie; Li, Kai; Zhang, Can

doi:10.31635/ccschem.020.202000330

Cited by 29 publications

(23 citation statements)

References 38 publications

(44 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Apart from mass loss and fibrosis, several disorders, including diabetes and Alzheimer's disease, are associated with aging [55]. A recent study showed that elastin in the brain might induce pathological changes in Alzheimer's disease, and elastin is known to be fragmented and released with aging [56]. Significant ECM changes, including increased expression of collagen IV and fibronectin, are presumed to affect disease progression in patients with Alzheimer's disease [16].…”

Section: Tissue Dysfunctionsmentioning

confidence: 99%

Employing Extracellular Matrix-Based Tissue Engineering Strategies for Age-Dependent Tissue Degenerations

Hwang

Jang

2021

IJMS

View full text Add to dashboard Cite

Tissues and organs are not composed of solely cellular components; instead, they converge with an extracellular matrix (ECM). The composition and function of the ECM differ depending on tissue types. The ECM provides a microenvironment that is essential for cellular functionality and regulation. However, during aging, the ECM undergoes significant changes along with the cellular components. The ECM constituents are over- or down-expressed, degraded, and deformed in senescence cells. ECM aging contributes to tissue dysfunction and failure of stem cell maintenance. Aging is the primary risk factor for prevalent diseases, and ECM aging is directly or indirectly correlated to it. Hence, rejuvenation strategies are necessitated to treat various age-associated symptoms. Recent rejuvenation strategies focus on the ECM as the basic biomaterial for regenerative therapies, such as tissue engineering. Modified and decellularized ECMs can be used to substitute aged ECMs and cell niches for culturing engineered tissues. Various tissue engineering approaches, including three-dimensional bioprinting, enable cell delivery and the fabrication of transplantable engineered tissues by employing ECM-based biomaterials.

show abstract

Section: Tissue Dysfunctionsmentioning

confidence: 99%

Employing Extracellular Matrix-Based Tissue Engineering Strategies for Age-Dependent Tissue Degenerations

Hwang

Jang

2021

IJMS

View full text Add to dashboard Cite

show abstract

“…There are three components involved in the assembly process, including positively charged protein, [21] carboxylated PEG and chemotherapeutic ALD. The PCP is derived from elastin‐like protein with randomly coiled sequence (VPGKG) 72 and present non‐immunogenicity particularly in the context of in vivo translations (Figure S1,S2) [22–24] . Before functional assembly and in vivo experiments, we purified PCP to collect endotoxin‐free and high‐purity sample for electrostatically complexation of anionic PEG moieties (Figure S3), yielding a non‐ covalently assembled protein nanoparticulate system.…”

Section: Figurementioning

confidence: 99%

Improving Bioavailability of Hydrophobic Prodrugs through Supramolecular Nanocarriers Based on Recombinant Proteins for Osteosarcoma Treatment

Wang

Zhang

et al. 2021

Angewandte Chemie

Self Cite

View full text Add to dashboard Cite

Supramolecular nanodrug assembly driven by supramolecular chemistry is becoming a powerful strategy for medication. The potential of engineered proteins as building blocks for nanoformulations is rarely investigated. Here, we developed a new generation of recombinant proteinbased nanodrug carriers, which is very efficient for loading and delivering the hydrophobic prodrug aldoxorubicin. Significantly enhanced anti-tumor effects in osteosarcoma (OS) models were observed. The half-life of the nanodrug reached almost two days and the corresponding bioavailability increased by 17-fold. This is significantly superior to other drug counterparts, empowering long-acting OS treatment scenarios. Importantly, off-target side effects of the prodrug, including cardiotoxicity and lung-metastasis, were greatly mitigated with our medication. Thus, our assembly strategy enables the customized design of advanced nanodelivery systems employing broader biomaterial building blocks for cancer therapy.

show abstract

“…Currently, elastins, spider silk spidroins, collagen, and bovine serum albumin (BSA) are the most common proteins used for the fabrication of protein-based biomaterials, showing promising applications in biomedicines, tissue engineering. [14][15][16][17][18][19] However, it is still difficult to translate these unique properties of nature proteins directly into synthetic materials just by conventional synthetic methods. The tedious synthetic routes are often needed as well as their weak biocompatibility/biodegradability limited their biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

Bioengineered Protein‐based Adhesives for Biomedical Applications

Sun

Han

Wang

et al. 2021

Chemistry A European J

Self Cite

View full text Add to dashboard Cite

Protein-based adhesives with their robust adhesion performance and excellent biocompatibility have been extensively explored over years. In particular, the unique adhesion behaviours of mussel and sandcastle worm inspired the development of synthetic adhesives. However, the chemical synthesized adhesives often demonstrate weak underwater adhesion performance and poor biocompatibility/biodegradability, limiting their further biomedical applications. In sharp contrast, genetically engineering endows the protein-based adhesives the ability to maintain underwater adhesion property as well as biocompatibility/biodegradability. Herein, we outline recent advances in the design and development of protein-based adhesives by genetic engineering. We summarize the fabrication and adhesion performance of elastin-like polypeptide-based adhesives, followed by mussel foot protein (mfp) based adhesives and other sources protein-based adhesives, such as, spider silk spidroin and suckerin. In addition, the biomedical applications of these bioengineered protein-based adhesives are presented. Finally, we give a brief summary and perspective on the future development of bioengineered protein-based adhesives.

show abstract

Extracellular Elastin Molecule Modulates Alzheimer’s Aβ Dynamics In Vitro and In Vivo by Affecting Microglial Activities

Abstract: suggest this revelation of the diverse functions of ELPs and other ECM may pave the way to uncover new specific microglia-targeted approaches related to AD and potentially other neurological disorders.

Cited by 29 publications

References 38 publications

Employing Extracellular Matrix-Based Tissue Engineering Strategies for Age-Dependent Tissue Degenerations

Employing Extracellular Matrix-Based Tissue Engineering Strategies for Age-Dependent Tissue Degenerations

Improving Bioavailability of Hydrophobic Prodrugs through Supramolecular Nanocarriers Based on Recombinant Proteins for Osteosarcoma Treatment

Bioengineered Protein‐based Adhesives for Biomedical Applications

Contact Info

Product

Resources

About