2001
DOI: 10.1590/s0100-879x2001000500004
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Abstract: The recently cloned extracellular calcium-sensing receptor (CaR) is a G protein-coupled receptor that plays an essential role in the regulation of extracellular calcium homeostasis. This receptor is expressed in all tissues related to this control (parathyroid glands, thyroid Ccells, kidneys, intestine and bones) and also in tissues with apparently no role in the maintenance of extracellular calcium levels, such as brain, skin and pancreas. The CaR amino acid sequence is compatible with three major domains: a … Show more

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Cited by 56 publications
(38 citation statements)
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“…Genetic studies have linked these cases to mutations in the CASR and PTH genes. The CASR gene, bound to the G protein and comprising 1078 amino acid residues, is located in chromosome 3q and codifies a cell surface receptor belonging to family C of the seven transmembrane receptor (7TM) superfamily (16,17). Predominantly expressed in the parathyroids and kidneys, this receptor regulates PTH secretion and the tubular excretion of calcium in response to fluctuations in calcium serum levels.…”
Section: Parathyroid Destructionmentioning
confidence: 99%
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“…Genetic studies have linked these cases to mutations in the CASR and PTH genes. The CASR gene, bound to the G protein and comprising 1078 amino acid residues, is located in chromosome 3q and codifies a cell surface receptor belonging to family C of the seven transmembrane receptor (7TM) superfamily (16,17). Predominantly expressed in the parathyroids and kidneys, this receptor regulates PTH secretion and the tubular excretion of calcium in response to fluctuations in calcium serum levels.…”
Section: Parathyroid Destructionmentioning
confidence: 99%
“…When extra-cellular calcium concentrations increase, the CASR activates the G protein pathway, stimulating the activity of phospholipases C, leading to the accumulation of inositol 1,4,5 triphosphate (IP3) and the liberation of calcium from intra-cellular storage. The increase of intracellular calcium results in the activation of protein kinase C, which in turn activates the MAPK's pathway, reducing the PTH gene transcription (15)(16)(17). The CASR is found in tissues unrelated to calcium homeostasis, such as the mammal gland, keratinocytes, central nervous system, pancreas, and epithelial cells, although its function has yet to be defined (16).…”
Section: Parathyroid Destructionmentioning
confidence: 99%
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“…Os CaRs humano (1078 aminoácidos) e do rato (1079 aminoá-cidos), possuem estruturas altamente conservadas, com 93% de identidade com o BoPCaR1 (2,6,11). As características estruturais do CaR humano incluem um largo domínio extracelular (ECD) amino-terminal de 612 aminoácidos, um domínio central com cerca de 250 aminoácidos formando sete regiões transmembranosas, característico dos receptores acoplados à superfamília da proteína G (GPCRs), e uma cauda carboxiterminal com mais de 200 aminoácidos (4,17).…”
Section: Receptor Sensível Ao Cálcio Extracelular (Car)unclassified
“…Entretanto, a calcitonina possui um efeito hipocalcêmico modesto em circunstâncias normais, quando comparado aos efeitos do PTH e da 1,25(OH) 2 D 3 (1,2,5). Assim, esses 3 hormônios calciotrópicos agem em seus órgãos efetores, principalmente osso, intestino e rins, alterando o transporte dos íons cálcio para o interior ou para o exterior do fluido extracelular, modulando desta forma a manutenção da homeostase desse íon (1,4).…”
Section: Introductionunclassified