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Cited by 116 publications
(158 citation statements)
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References 39 publications
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“…In a wider study with six different cancer cell lines, ATP treatment protected against DOX-induced cytotoxicity only in non-metastatic CL1.0 lung cancer cells [31]. Few studies have shown that extracellular ATP promotes survival in non-small cell lung cancer A549 cell line [32,33]. However, this has not been shown to be a cause of enhanced DNA damage resistance.…”
Section: Discussionmentioning
confidence: 98%
“…In a wider study with six different cancer cell lines, ATP treatment protected against DOX-induced cytotoxicity only in non-metastatic CL1.0 lung cancer cells [31]. Few studies have shown that extracellular ATP promotes survival in non-small cell lung cancer A549 cell line [32,33]. However, this has not been shown to be a cause of enhanced DNA damage resistance.…”
Section: Discussionmentioning
confidence: 98%
“…This is likely to be especially important during cancer, when these metabolic responses are crucial (Tsun and Possemato, 2015). A recent report suggests that cancer cells can even boost their ATP levels directly by ingesting it through macropinocytosis when they are in microenvironments in which extracellular ATP is abundant (Qian et al, 2014).…”
Section: Macropinocytosis In Life and Death -Roles For Rasmentioning
confidence: 99%
“…But under condition where Apaf-1 is overexpressed, the cell does not have enough amounts of these cofactors for maintenance of closed form of exogenous Apaf-1. As noted the cancer cells produce more ATP using upregulated aerobic glycolysis (Qian et al, 2014).…”
Section: Overexpression Of Mutants (E546q and E546r)mentioning
confidence: 88%
“…HEK293T cells are a transformed human cell line while HL-60 is a cancer cell line (Graham et al, 1977;Thomas and Smart, 2005). Cancer cell lines are able to produce more ATP using the Warburg effect (Qian et al, 2014). Thus, higher level of ATP may facilitate activation of abundant/overexpressed Apaf-1 and apoptosome formation (Perkins et al, 1998).…”
Section: Overexpression Of Mutants (E546q and E546r)mentioning
confidence: 99%