Extra-column band spreading in high-performance liquid chromatography-mass spectrometry using a moving belt interface

Commentary: Challenging convention using ambient ionization and direct analysis mass spectrometric techniques

“…This was exemplified using rapid throughput TD/APCI-MS (10 samples/min) of diacetylmorphine on banknotes using a custom-made interface in real time, [11] when regulations potentially require hundreds of individual notes to be screened in a given investigation. Another configuration showed a belt-drive desorber, somewhat akin to the classic moving-belt LC/MS interface, [12] where samples taken from a remote crime scene (e.g. car, business premises) using a clean lint brush were held against a moving belt which moved into a hot thermal desorption region for analysis.…”

Commentary: Challenging convention using ambient ionization and direct analysis mass spectrometric techniques

“…This was exemplified using rapid throughput TD/APCI-MS (10 samples/min) of diacetylmorphine on banknotes using a custom-made interface in real time, [11] when regulations potentially require hundreds of individual notes to be screened in a given investigation. Another configuration showed a belt-drive desorber, somewhat akin to the classic moving-belt LC/MS interface, [12] where samples taken from a remote crime scene (e.g. car, business premises) using a clean lint brush were held against a moving belt which moved into a hot thermal desorption region for analysis.…”

A new transport detector for high-performance liquid chromatography based on thermospray vaporization

“…One of the major problems with the transport devices, particularly for reversed-phase LC, is that it is difficult to rapdily vaporize polar solvents from a surface without losing a significant and uncontrolled fraction of many samples. 0003-2700/84/0356-2632$01.50/0 Various approaches to solving this problem have been studied in connection with LC/MS interfacing including a segmented flow reactor (20), use of microbore LC (21), and spray deposition either by gas flow nebulization (17)(18)(19) or by thermospray (22). Spray deposition allows samples somewhat less volatile than the solvent to be efficiently transferred to the surface of a moving belt while most of the solvent is vaporized and removed without deposition as liquid on the surface.…”

Commentary: Challenging convention using ambient ionization and direct analysis mass spectrometric techniques

“…This was exemplified using rapid throughput TD/APCI-MS (10 samples/min) of diacetylmorphine on banknotes using a custom-made interface in real time, [11] when regulations potentially require hundreds of individual notes to be screened in a given investigation. Another configuration showed a belt-drive desorber, somewhat akin to the classic moving-belt LC/MS interface, [12] where samples taken from a remote crime scene (e.g. car, business premises) using a clean lint brush were held against a moving belt which moved into a hot thermal desorption region for analysis.…”

A new transport detector for high-performance liquid chromatography based on thermospray vaporization

“…One of the major problems with the transport devices, particularly for reversed-phase LC, is that it is difficult to rapdily vaporize polar solvents from a surface without losing a significant and uncontrolled fraction of many samples. 0003-2700/84/0356-2632$01.50/0 Various approaches to solving this problem have been studied in connection with LC/MS interfacing including a segmented flow reactor (20), use of microbore LC (21), and spray deposition either by gas flow nebulization (17)(18)(19) or by thermospray (22). Spray deposition allows samples somewhat less volatile than the solvent to be efficiently transferred to the surface of a moving belt while most of the solvent is vaporized and removed without deposition as liquid on the surface.…”

Commentary: Challenging convention using ambient ionization and direct analysis mass spectrometric techniques

“…This was exemplified using rapid throughput TD/APCI-MS (10 samples/min) of diacetylmorphine on banknotes using a custom-made interface in real time, [11] when regulations potentially require hundreds of individual notes to be screened in a given investigation. Another configuration showed a belt-drive desorber, somewhat akin to the classic moving-belt LC/MS interface, [12] where samples taken from a remote crime scene (e.g. car, business premises) using a clean lint brush were held against a moving belt which moved into a hot thermal desorption region for analysis.…”

A new transport detector for high-performance liquid chromatography based on thermospray vaporization

“…One of the major problems with the transport devices, particularly for reversed-phase LC, is that it is difficult to rapdily vaporize polar solvents from a surface without losing a significant and uncontrolled fraction of many samples. 0003-2700/84/0356-2632$01.50/0 Various approaches to solving this problem have been studied in connection with LC/MS interfacing including a segmented flow reactor (20), use of microbore LC (21), and spray deposition either by gas flow nebulization (17)(18)(19) or by thermospray (22). Spray deposition allows samples somewhat less volatile than the solvent to be efficiently transferred to the surface of a moving belt while most of the solvent is vaporized and removed without deposition as liquid on the surface.…”