External Contact With Monoethyl Ether of Diethylene Glycol (Carbitol Solvent)

Toxicity studies used in registration, evaluation, authorisation and restriction of chemicals (REACH): How accurately are they reported?

“…Overall, differences were observed in how and to what extent information from the published studies was reflected or reported in the study summaries, but to a varying degree. Some studies were generally well reflected in the study summaries with only a few deviations (e.g., Cranch et al 1942;Goldberg et al 1964;Penninks and Seinen 1982). In contrast, summaries for other studies differed more both in the extent of information that was included as well as in how the information was reported (e.g., Loeser and Lorke 1976a;Maltoni et al 1986;Ballantyne et al 2006).…”

“…The study by van der Ven et al (2006) was Lake et al (1983): The purity for the substance used in the metabolic study was reported instead of the substance used in the toxicological test, for which only information on supplier was reported in the published study. Cranch et al (1942): Ten animals per dose group was reported when seemingly 10 animals were used in total.…”