External beam radiotherapy of choroidal metastases – final results of a prospective study of the German Cancer Society (ARO 95-08)

Wiegel, Thomas; Bottke, Dirk; Kreusel, Klaus-Martin; Schmidt, Stephanie; Bornfeld, Norbert; Foerster, Michael; Hinkelbein, W.

doi:10.1016/s0167-8140(02)00134-2

Cited by 129 publications

(123 citation statements)

References 16 publications

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“…The average survival following a diagnosis of uveal metastases is 7 months. 10,11 This fact is important when deciding between treatments. There is a wide range of management options for intraocular metastases.…”

Section: Treatmentmentioning

confidence: 99%

Ocular metastases

Cohen

2012

Eye

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The eye is a rare site for disseminated malignancy because of the absence of a lymphatic system. Metastases to the ocular structures occur by haematogenous spread and therefore the parts of the eye with the best vascular supply are most likely to be affected. Many patients with Stage 4 carcinomatosis (distal metastatic spread) already have a history of a previous primary cancer. However, this is not always the case for lung cancer as this can metastasise early to the uveal tract and therefore the ophthalmologist may be the first to discover the presence of terminal metastatic disease. Broadly speaking, treatment options are focused on improving the patients' quality of life if visual acuity is threatened. Long-term side effects of treatment need to be considered as systemic cancer treatments and therefore patient life expectancy is improving. In this manuscript, presented at the Cambridge symposium 2012, the diagnosis and challenges involved in the management of ocular metastases are presented.

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Section: Treatmentmentioning

confidence: 99%

Ocular metastases

Cohen

2012

Eye

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“…14,16 In a series of 188 patients treated with EBRT reported by Rudoler and colleagues 16 36% of legally blind eyes regained useful vision and 93% experienced no clinical evidence of tumour progression with a globe preservation rate of 98%. A prospective German Cancer Society study 17 of 50 patients with choroidal metastases secondary to breast cancer treated with EBRT to 40 Gy in 20 fractions demonstrated stabilization or improvement in visual acuity in 86% of patients. A complete or partial response, as measured by ultrasonography, was seen in 63% of patients.…”

Section: Discussionmentioning

confidence: 99%

Prolonged survival in a patient with choroidal metastases from urothelial bladder cancer

Wiltshire

Laperriere

Bristow

2013

CUAJ

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Choroidal metastases secondary to urothelial carcinoma are extremely rare and are usually associated with an extremely poor prognosis. We present a case of an 88-year-old man with newly diagnosed urothelial carcinoma of the bladder who presented with acute loss of vision before commencing definitive concurrent chemoradiotherapy to the bladder. Ophthalmological examination demonstrated bilateral choroidal metastases. He received palliative radiotherapy to the orbits and completed his planned radiotherapy to the bladder. He remained disease-free at last follow-up 4 years after the completion of treatment. We review the literature particularly with regard to diagnosis and management of choroidal metastases. Choroidal metastases should be considered in a patient with a history of urothelial cancer presenting with new onset of eye symptoms.

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“…1,5 Tumour and symptom response have been demonstrated in 63% to 83% of cases; however, half of these studies were performed in breast cancer and the generalizability of these results to other histologies is uncertain. [33][34][35][36][37][38] Potential side effects include skin erythema, conjunctivitis, corneal ulceration, cataract formation, retinopathy and neuropathy. 1,33,34 When response to the above modalities is incomplete, surgical debulking can improve cosmesis and visual acuity.…”

Section: Treatmentmentioning

confidence: 99%

Genitourinary malignancy presenting as an ocular metastasis: A case report and review of the literature

Lefresne¹,

Fairchild²,

Johnson³

et al. 2012

CUAJ

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E67Case report Genitourinary malignancy presenting as an ocular metastasis: A case report and review of the literature Cite as: Can Urol Assoc J 2012;6(2):e67-71. http://dx.doi.org/10.5489/cuaj.10174 AbstractMetastases to the eye or orbit as the initial presentation of genitourinary malignancy are unusual and can be a diagnostic challenge. We report an 81-year-old man who presented with pain and proptosis in an eye that had been blind for 50 years. Radiologic investigations identified a mass involving the left globe and orbit. Histology of the enucleation specimen was consistent with a metastatic poorly differentiated carcinoma suggestive of a prostate primary. With the constellation of obstructive urinary symptoms, an abnormal digital rectal examination, elevated prostate-specific antigen and a positive bone scan, androgen deprivation therapy was initiated for metastatic prostate cancer. After an initial response to treatment, the patient's disease progressed in a manner atypical for prostate cancer. After describing our case, we review the literature on ocular and orbital metastases and their relation to genitourinary malignancies.

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External beam radiotherapy of choroidal metastases – final results of a prospective study of the German Cancer Society (ARO 95-08)

Cited by 129 publications

References 16 publications

Ocular metastases

Ocular metastases

Prolonged survival in a patient with choroidal metastases from urothelial bladder cancer

Genitourinary malignancy presenting as an ocular metastasis: A case report and review of the literature

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