External Beam Radiotherapy in Retinoblastoma

Abstract

Objective: To investigate eye conservation, local control, and complication rates among children with retinoblastoma treated with 2 different external beam radiotherapy (EBR) techniques.Methods: Fifty-eight eyes in 42 patients received EBR as the primary treatment modality for retinoblastoma (median follow-up, 37 months). The EBR technique was relative lens-sparing (RLS) in 26 eyes and modified lateral beam (MLB) in 32 eyes. Both groups were comparable in Reese-Ellsworth retinoblastoma classification. If necessary, patients received focal salvage therapy.Results: At 24 months, eye conservation rates were 88.5% and 89.1% among eyes treated with RLS and MLB, respectively (P = .40); tumor control rates without salvage therapy were 84.6% and 53.3% (P = .02), respectively. Among eyes with Reese-Ellsworth stage IV and V disease, eye conservation rates were 88% ± 8% and 83% ± 9% at 36 months in the RLS and MLB groups, respectively, and local tumor control rates were 81% ± 10% and 51% ± 12%. Percentages of eyes without cataract at 36 months were 83.1% and 63.0%, respectively (P = .40). Among patients observed for at least 18 months, midfacial hypoplasia developed in 38.5% and 29.4%, respectively (P = .70). Conclusions:The EBR technique was associated with high eye conservation and local control rates. Salvage therapy was performed significantly less frequently in the RLS group compared with the MLB group, and complication rates in both groups were similar.

Hyperfractionated External Beam Radiation Therapy in the Treatment of Murine Transgenic Retinoblastoma

“…Focal delivery to the eye, new megavoltage machines, and lens-sparing techniques have contributed to the increasing efficacy of this treatment modality, improving ocular and visual prognoses, while decreasing treatmentrelated morbidities. 34 The current study demonstrates that hyperfractionation (increasing the frequency of radiation treatment, while decreasing the fraction delivered per treatment) is significantly associated with increased tumor control in a murine transgenic model of retinoblastoma.…”

Hyperfractionated External Beam Radiation Therapy in the Treatment of Murine Transgenic Retinoblastoma

“…Focal delivery to the eye, new megavoltage machines, and lens-sparing techniques have contributed to the increasing efficacy of this treatment modality, improving ocular and visual prognoses, while decreasing treatmentrelated morbidities. 34 The current study demonstrates that hyperfractionation (increasing the frequency of radiation treatment, while decreasing the fraction delivered per treatment) is significantly associated with increased tumor control in a murine transgenic model of retinoblastoma.…”

Anecortave Acetate as Single and Adjuvant Therapy in the Treatment of Retinal Tumors of LHBETATAGMice

“…Recently, clinical advances have focused on increasing tumor control and globe conservation with attendant preservation of sight. [2][3][4][5][6] Current available treatments include laser therapy, cryotherapy, external beam radiotherapy, charged-particle radiation, and systemic chemotherapy. 7,8 Serious concerns exist regarding the significant morbidity and potential mortality associated with current therapies in the treatment of retinoblastoma; therefore, newer therapeutic modalities are being investigated.…”

Retinoblastoma gene expression profiling based on bioinformatics analysis

“…RB is one of the most serious eye diseases that can result in blindness, disability, and even death in infants [ 26 – 28 ]. Thus, the progression of novel strategies to diagnose and treat RB requires a detailed understanding of the mechanisms involved.…”

Hyperfractionated External Beam Radiation Therapy in the Treatment of Murine Transgenic Retinoblastoma

“…Focal delivery to the eye, new megavoltage machines, and lens-sparing techniques have contributed to the increasing efficacy of this treatment modality, improving ocular and visual prognoses, while decreasing treatmentrelated morbidities. 34 The current study demonstrates that hyperfractionation (increasing the frequency of radiation treatment, while decreasing the fraction delivered per treatment) is significantly associated with increased tumor control in a murine transgenic model of retinoblastoma.…”

Anecortave Acetate as Single and Adjuvant Therapy in the Treatment of Retinal Tumors of LHBETATAGMice

“…Recently, clinical advances have focused on increasing tumor control and globe conservation with attendant preservation of sight. [2][3][4][5][6] Current available treatments include laser therapy, cryotherapy, external beam radiotherapy, charged-particle radiation, and systemic chemotherapy. 7,8 Serious concerns exist regarding the significant morbidity and potential mortality associated with current therapies in the treatment of retinoblastoma; therefore, newer therapeutic modalities are being investigated.…”

Retinoblastoma gene expression profiling based on bioinformatics analysis

“…RB is one of the most serious eye diseases that can result in blindness, disability, and even death in infants [ 26 – 28 ]. Thus, the progression of novel strategies to diagnose and treat RB requires a detailed understanding of the mechanisms involved.…”

Hyperfractionated External Beam Radiation Therapy in the Treatment of Murine Transgenic Retinoblastoma

“…Focal delivery to the eye, new megavoltage machines, and lens-sparing techniques have contributed to the increasing efficacy of this treatment modality, improving ocular and visual prognoses, while decreasing treatmentrelated morbidities. 34 The current study demonstrates that hyperfractionation (increasing the frequency of radiation treatment, while decreasing the fraction delivered per treatment) is significantly associated with increased tumor control in a murine transgenic model of retinoblastoma.…”

Anecortave Acetate as Single and Adjuvant Therapy in the Treatment of Retinal Tumors of LHBETATAGMice

“…Recently, clinical advances have focused on increasing tumor control and globe conservation with attendant preservation of sight. [2][3][4][5][6] Current available treatments include laser therapy, cryotherapy, external beam radiotherapy, charged-particle radiation, and systemic chemotherapy. 7,8 Serious concerns exist regarding the significant morbidity and potential mortality associated with current therapies in the treatment of retinoblastoma; therefore, newer therapeutic modalities are being investigated.…”

Retinoblastoma gene expression profiling based on bioinformatics analysis

“…RB is one of the most serious eye diseases that can result in blindness, disability, and even death in infants [ 26 – 28 ]. Thus, the progression of novel strategies to diagnose and treat RB requires a detailed understanding of the mechanisms involved.…”