Extent of Resection and Survival in Glioblastoma Multiforme

Stummer, Walter; Reulen, Hanns-Jürgen; Meinel, Thomas; Pichlmeier, Uwe; Schumacher, Wiebke; Tonn, Jörg‐Christian; Rohde, Veit; Oppel, F.; Turowski, Bernd; Woiciechowsky, Christian; Franz, Kea; Pietsch, Torsten

doi:10.1227/01.neu.0000317304.31579.17

Cited by 924 publications

(387 citation statements)

References 16 publications

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“…Residual tumor after surgical resection is an independent prognostic factor for survival. 4,6) Although complete tumor resection is desirable, gliomas often can be only partially resected in order to preserve brain function. Residual tumor cells inevitably recur within a certain interval even after intensive radiotherapy and chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

Detection of Tumor Progression by Signal Intensity Increase on Fluid-Attenuated Inversion Recovery Magnetic Resonance Images in the Resection Cavity of High-Grade Gliomas

Ito-Yamashita

Nakasu

Mitsuya

et al. 2013

Neurol. Med. Chir.(Tokyo)

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Increased signal intensity (SI) on fluid-attenuated inversion recovery (FLAIR) magnetic resonance (MR) images in the resection cavity is sometimes observed after partial resection of gliomas. SI in the resection cavity of 44 high-grade gliomas was retrospectively investigated. Twelve of 35 patients with progressive disease (PD) showed SI increase in the resection cavity, and SI increase preceded PD in 6 of these 12 patients. None of nine patients without PD showed SI increase during the follow-up period. The analysis of SI on FLAIR images in the resection cavity had a specificity of 100% and a sensitivity of 34%. Higher sensitivity was found in grade IV tumors than in grade III tumors. SI increase is thus considered as a potent highly specific hallmark for subsequent or coincident tumor progression, which is clinically useful since MR imaging is easily performed during routine clinical examinations.

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Section: Introductionmentioning

confidence: 99%

Detection of Tumor Progression by Signal Intensity Increase on Fluid-Attenuated Inversion Recovery Magnetic Resonance Images in the Resection Cavity of High-Grade Gliomas

Ito-Yamashita

Nakasu

Mitsuya

et al. 2013

Neurol. Med. Chir.(Tokyo)

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“…Surgery and RT are still considered the basic treatment, and can be complemented with chemotherapy [1][2][3][4]6,13,[15][16][17][18][19][20]. The present investigation revealed that survival time of patients from group 2 (11.9 months) was statistically superior to that of patients from group 1 (7.4 months).…”

Section: Discussionmentioning

confidence: 60%

“…This study aims at comparing the survival of supratentorial adult GBM patients operated on at public hospital with that of GBM patients operated on at the private hospital and observe, if besides the previously identified prognostic factors [1][2][3][4][5][6][7] , socioeconomic factors, as previous reported by several authors, interfere in the GBM patients' survival in Brazil [8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Effects of Socioeconomic on Survival for Adult Glioblastoma Multiform Patients in Rio de Janeiro, Brazil, 1999-2009

Lynch¹,

Welling²,

Escosteguy³

et al. 2012

OJMN

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Backgrond: To compare the survival of glioblastoma multiforme (GBM) patients operated on at public hospital with that of patients operated on at the private hospital. Method: We carried out a retrospective analysis of the patients' medical records, the surgical reports, and the pre and post-operative images of patients with a histopathological confirmed adult supratentorial glioblastoma multiform (GBM). Sixty-three patients were treated at public hospital and 21 at private hospitals. Results: The present study revealed that the survival of patients treated in private hospitals was statistically superior to that of patients treated in public hospitals (11.9 vs 7.7). Conclusions: Our study advances towards the confirmation of the hypothesis that socioeconomic and educational factors influence the KPS and the performance of RT treatment, with negative effects over the GBM patients' survival.

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“…Intraoperative fluorescence contrast agents have been frequently mentioned in the literature. They improve the visualization of brain tumors during surgery and support complete resection (22,23). Preoperative injection of carbocyanine-labeled GfM may facilitate the macroscopic detection of tumor (Fig.…”

Section: Discussionmentioning

confidence: 99%

Gadofluorine M enhanced MRI in experimental glioma: Superior and persistent intracellular tumor enhancement compared with conventional MRI

Jestaedt

Lemke

Weiler

et al. 2011

Magnetic Resonance Imaging

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Purpose: To compare conventional magnetic resonance imaging (MRI) techniques (T2‐w and Gadolinium‐DTPA‐enhanced T1‐w images) and Gadofluorine‐M (GfM), a novel contrast agent in MRI, in murine gliomas. Materials and Methods: Growth monitoring of murine gliomas (induced in mice) was performed on a 2.3 Tesla Bruker Biospec MRI unit. First all animals were investigated with conventional MRI techniques. In group I GfM was applied at an early stage of disease, in group II at a later stage. After injection of GfM follow‐up MRI was performed without further injection of contrast agent. On MR images tumor size and signal intensities were assessed. Animals were killed for histological evaluation. Results: In both groups GfM delineated tumor extents larger and more precisely than conventional MRI techniques. The difference between GfM and conventional MRI techniques reached level of significance at both tumor stages. Follow‐up MRI after singular injection of GfM showed persistence of GfM in tumor tissue. On tissue sections GfM‐enhancing areas corresponded closely to vital tumor tissue. GfM showed a mainly intracellular accumulation. Conclusion: Application of GfM resulted in superior delineation of experimental glioma compared with conventional MRI techniques. Thus, GfM bears a high potential in clinical application. J. Magn. Reson. Imaging 2012;35:551‐560. © 2011 Wiley Periodicals, Inc.

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Extent of Resection and Survival in Glioblastoma Multiforme

Cited by 924 publications

References 16 publications

Detection of Tumor Progression by Signal Intensity Increase on Fluid-Attenuated Inversion Recovery Magnetic Resonance Images in the Resection Cavity of High-Grade Gliomas

Detection of Tumor Progression by Signal Intensity Increase on Fluid-Attenuated Inversion Recovery Magnetic Resonance Images in the Resection Cavity of High-Grade Gliomas

Effects of Socioeconomic on Survival for Adult Glioblastoma Multiform Patients in Rio de Janeiro, Brazil, 1999-2009

Gadofluorine M enhanced MRI in experimental glioma: Superior and persistent intracellular tumor enhancement compared with conventional MRI

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