Extent of resection and survival for oligodendroglioma: a U.S. population-based study

Kinslow, Connor J.; Garton, A.; Rae, Ali I.; Marcus, Logan P.; Adams, Christopher M.; McKhann, Guy M.; Sisti, Michael B.; Connolly, E. Sander; Bruce, Jeffrey N.; Neugut, Alfred I.; Sonabend, Adam M.; Canoll, Peter; Cheng, Simon K.; Wang, Tony J. C.

doi:10.1007/s11060-019-03261-5

Cited by 51 publications

(46 citation statements)

References 57 publications

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“…Further, in contrast to different chemotherapy regimens, resection is able to stand out with significant survival improvement although the data are relatively fuzzy and biased through multiple therapies. In contrast to published data [8,16,17], we found that patients benefit from a resection if the residual tumor is less than 50%. Based on our results we would like to emphasize that the success of a resection is not binary but rather a function that reflects a negative correlation between survival and residual tumor.…”

Section: Discussioncontrasting

confidence: 99%

Characterization of longitudinal transformation of T2-hyperintensity in oligodendroglioma

et al. 2020

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Background: Oligodendroglioma (ODG) are CNS resistant tumors characterized by their unique molecular signature, namely a combined deletion of 1p and 19q simultaneously to an IDH1/2 mutation. These tumors have a more favorable clinical outcome compared to other gliomas and a long-time survival that ranges between 10 and 20 years. However, during the course of the disease, multiple recurrences occur and the optimal treatment at each stage of the disease remains unclear. Here we report a retrospective longitudinal observation study of 836 MRI examinations in 44 ODG patients. Methods: We quantified the volume of T2-hyperintensity to compute growth behavior in dependence of different treatment modalities, using various computational models. Results: The identified growth pattern revealed dynamic changes, which were found to be patient-specific an did not correlate with clinical parameter or therapeutic interventions. Further, we showed that, surgical resection is beneficial for overall survival regardless the WHO grad or timepoint of surgery. To improve overall survival, an extent of resection above 50% is required. Multiple resections do not generally improve overall survival, except a greater extent of resection than in previous surgeries was achieved. Conclusions: Our data aids to improve the interpretation of MRI images in clinical practice.

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Section: Discussioncontrasting

confidence: 99%

Characterization of longitudinal transformation of T2-hyperintensity in oligodendroglioma

et al. 2020

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show abstract

“…Further, in contrast to different chemotherapy regimens, resection is able to stand out with significant survival improvement although the data are relatively fuzzy and biased through multiple therapies. In contrast to published data[7, 14, 15], we found that patients benefit from a resection if the residual tumor is less than 50%. Based on our results we would like to emphasize that the success of a resection is not binary but rather a function that reflects a negative correlation between survival and residual tumor.…”

Section: Discussioncontrasting

confidence: 99%

Characterization of longitudinal transformation of T2-hyperintensity in oligodendroglioma

Heiland

Ohle

Cipriani

et al. 2020

Preprint

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Background: Oligodendroglioma (ODG) are CNS resistant tumors characterized by their unique molecular signature, namely a combined deletion of 1p and 19q simultaneously to an IDH1/2 mutation. These tumors have a more favorable clinical outcome compared to other gliomas and a long-time survival that ranges between 10-20 years. However, during the course of the disease, multiple recurrences occur and the optimal treatment at each stage of the disease remains unclear. Here we report a retrospective longitudinal observation study of 836 MRI examinations in 44 ODG patients. Methods: We quantified the volume of T2-hyperintensity to compute growth behavior in dependence of different treatment modalities, using various computational models. Results: The identified growth pattern revealed dynamic changes, which were found to be patient-specific an did not correlate with clinical parameter or therapeutic interventions. Further, we showed that, surgical resection is beneficial for overall survival regardless the WHO grad or timepoint of surgery. To improve overall survival, an extent of resection above 50% is required. Multiple resections do not generally improve overall survival, except a greater extent of resection than in previous surgeries was achieved. Conclusions: Our data aids to improve the interpretation of MRI images in clinical practice.

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“…Shin et al reported that adjuvant chemotherapy was an independent prognostic factor for improved OS 14 . Numerous studies highlight EOR in association with prognosis 2,[6][7][8][15][16][17] . Based on our results, we should attempt GTR which could be enhanced by 5-aminolevulinic acid (5-ALA) 16 .…”

Section: Discussionmentioning

confidence: 99%

Survival outcome and prognostic factors in anaplastic oligodendroglioma: a single-institution study of 95 cases

Shin

Lee

Song

et al. 2020

Sci Rep

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The aim of this study was to evaluate prognostic factors including surgical, radiographic, and histopathologic analyses in anaplastic oligodendroglioma (AO) patients. We reviewed the electronic records of 95 patients who underwent surgery and were diagnosed with AO for 20 years. The primary endpoints were progression-free survival (PFS) and overall survival (OS). Univariate and multivariable analyses included clinical, histopathological, and radiographic prognostic factors. Subgroup analysis was performed in isocitrate dehydrogenase (IDH1/2)-mutant and 1p/19q-codeleted patients. The median PFS and OS were 24.7 months and 50.8 months, respectively. The 1-, 3-, 5-, and 10-year PFS were 75.8%, 42.9%, 32.4%, and 16.4%, respectively. Furthermore, the 1-, 3-, 5-, and 10-year OS were 98.9%, 76.9%, 42.9%, and 29.7%, respectively. The median PFS and OS of the IDH1/2-mutant and 1p/19q-codeleted patients were 54.2 and 57.8 months, respectively. In univariate analyses, young age, frontal lobe, weak enhancement, gross total resection (GTR), low Ki-67 index, 1p/19q codeletion, and IDH1/2 mutations were associated with a favorable outcome. In multivariable analyses, IDH1/2 mutation was related to better PFS and OS. In subgroup analysis, GTR was associated with favorable outcomes.

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Extent of resection and survival for oligodendroglioma: a U.S. population-based study

Cited by 51 publications

References 57 publications

Characterization of longitudinal transformation of T2-hyperintensity in oligodendroglioma

Characterization of longitudinal transformation of T2-hyperintensity in oligodendroglioma

Characterization of longitudinal transformation of T2-hyperintensity in oligodendroglioma

Survival outcome and prognostic factors in anaplastic oligodendroglioma: a single-institution study of 95 cases

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