Emmanuel J. Barbeau, Mira Didic, Sven Joubert, Eric Guedj, Lejla Koric, Olivier Felician, Jean-Philippe Ranjeva, Patrick Cozzone, Mathieu Ceccaldi
Abstract:An increasing number of studies indicate that semantic memory is impaired in mild cognitive impairment (MCI). However, the extent and the neural basis of this impairment remain unknown. The aim of the present study was: 1) to evaluate whether all or only a subset of semantic domains are impaired in MCI patients; and 2) to assess the neural substrate of the semantic impairment in MCI patients using voxel-based analysis of MR grey matter density and SPECT perfusion. 29 predominantly amnestic MCI patients and 29 …
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