Extensive nodular secondary syphilis

Sapra, S.

doi:10.1001/archderm.125.12.1666

Cited by 6 publications

(2 citation statements)

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“…suggested that nodular lesions represented a transition to the tertiary phase, while Pandhi et al. suggested that they might be a reaction of specific hypersensitivity to the treponemal infection 3,4 . In the present case, the hypersensitive reaction and the use of topical glucocorticoids may have been the cause of the granulation tissue‐like nodules because the lesions appeared 6 months after the extramarital sexual intercourse.…”

mentioning

confidence: 58%

Localized granulation tissue‐like nodules: An unusual cutaneous presentation of secondary syphilis

Zhang

Xiao

et al. 2011

The Journal of Dermatology

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confidence: 58%

Localized granulation tissue‐like nodules: An unusual cutaneous presentation of secondary syphilis

Zhang

Xiao

et al. 2011

The Journal of Dermatology

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“…13 Others have suggested that the nodular presentation may represent the transition to tertiary syphilis. 14 One group suggested that their patient's presentation may have been due to an incorrectly prescribed medication with properties that alter the immune system. 15 Although there has been no association of nodular secondary syphilis with HIV infection to date, interestingly each of our nodular syphilis patients were confirmed to be HIV-positive.…”

Section: Discussionmentioning

confidence: 99%

Nodular secondary syphilis in three HIV-positive patients: a case series

et al. 2020

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Nodular secondary syphilis is an uncommon variant of secondary syphilis. We identified three cases of nodular secondary syphilis at our institution. The first patient presented with a diffuse nodular rash that included his scrotum and penis. The second patient had disseminated skin-colored nodules with serosanguinous crust on his face, trunk, and extremities. The third patient had a pruritic papular and nodular rash with overlying crust. All three patients had a reactive rapid plasma reagin and tested positive for fluorescent treponemal antibody absorption. All were eventually confirmed to be human immunodeficiency virus-positive. Histopathological examination demonstrated inflammatory infiltrate in the dermis composed of lymphocytes, histiocytes, and plasma cells, and treponemal staining highlighted spirochetes in the dermis. The patients were successfully treated with intramuscular penicillin benzathine G. Physicians should be aware of nodular syphilis as a less common cutaneous manifestation of secondary syphilis. Prompt diagnosis of secondary syphilis can expedite resolution of the infection and avoid progression to tertiary syphilis.

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