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Cited by 383 publications
(281 citation statements)
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“…3b) ( P  = 0.30). Previous reports have shown that Ames dwarf mice are more insulin sensitive compared to control mice when they are fed STD (Bartke, 2008; and Bartke et al ., 2011). As expected, Ames dwarf mice fed STD were more insulin sensitive compared to control mice fed STD as shown by area under the curve ( P  < 0.004) (Fig.…”
Section: Resultsmentioning
confidence: 99%
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“…3b) ( P  = 0.30). Previous reports have shown that Ames dwarf mice are more insulin sensitive compared to control mice when they are fed STD (Bartke, 2008; and Bartke et al ., 2011). As expected, Ames dwarf mice fed STD were more insulin sensitive compared to control mice fed STD as shown by area under the curve ( P  < 0.004) (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…al ., 2003; Bartke, 2008), and can reduce life expectancy in both mice (Brown‐Borg et al ., 1996; Bartke et al ., 1998) and humans (Chertman et al ., 2000). Disruption of GH signaling by either reducing plasma GH levels or by GH receptor deletion significantly extends lifespan in mice as reported in Ames dwarf mice, Snell dwarf mice, GH receptor/GH‐binding protein gene knockout mice (GHR‐KO mice), and GH‐releasing hormone knockout mice (GHRH‐KO) (Brown‐Borg et al ., 1996; Coschigano et al ., 2000; Bartke et al ., 2011). Longevity may also be altered by metabolic stressors such as increased calorie consumption from diets high in fat.…”
Section: Introductionmentioning
confidence: 99%
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“…SREBP‐1c is the primary isoform expressed in insulin‐sensitive tissues such as the liver, WAT, and muscle (Shimano, 2009). Because CR further extended lifespan of two long‐lived strains, Ames dwarf mice and heterozygous antisense GH transgenic rats (Bartke et al ., 2001; Shimokawa et al ., 2003), we examined the role of GH/IGF‐1 in CR‐associated gene expression profiles of WAT in a previous study. Our findings suggested that CR‐associated alterations of gene expression were highly regulated, in a GH/IGF‐1‐independent manner.…”
Section: Introductionmentioning
confidence: 99%
“…Suppression of growth hormone (GH) and insulin like growth factor 1 (IGF‐1) signaling pathway provides the most significant lifespan extension on animal models (Bartke et al ., 2001; Bartke & Brown‐Borg, 2004). One well‐established model for aging and longevity research is the Ames dwarf mouse (df/df; Bartke et al ., 2001; Bartke & Brown‐Borg, 2004; Masternak et al ., 2004; Dhahbi et al ., 2007; Bates et al ., 2010; Menon et al ., 2014). This mutant mouse is characterized by the deficiency in three pituitary hormones including GH, prolactin, and thyrotropin due to homozygous, spontaneous mutation in the prophet of pituitary factor 1 (Prop1), a transcription factor responsible for pituitary development.…”
Section: Introductionmentioning
confidence: 99%