Extended-spectrum β-lactamases producing Enterobacteriaceae (ESBL-PE) prevalence in Nepal: A systematic review and meta-analysis

Khadka, Christina; Shyaula, Manita; Syangtan, Gopiram; Bista, Shrijana; Tuladhar, Reshma; Singh, Anjana; Joshi, Dev Raj; Pokhrel, Lok R.; Dawadi, Prabin

doi:10.1016/j.scitotenv.2023.166164

Cited by 3 publications

(2 citation statements)

References 93 publications

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“…Gram-negative Enterobacteriaceae, such as Salmonella spp, Klebsiella pneumoniae , and E. coli are the primary producers of ESBLs ( Khadka et al, 2023 ). In bacteria, the synthesis of B- lactamases is thought to be the principal mechanism of resistance to B-lactam antibiotics.…”

Section: Discussionmentioning

confidence: 99%

“…In bacteria, the synthesis of B- lactamases is thought to be the principal mechanism of resistance to B-lactam antibiotics. ESBLs are often encoded by large plasmids that can be passed from one bacterial species to the next ( Khadka et al, 2023 ). The most common types of β-lactamases are classified into the following groups: Resistance to first and second generation cephalosporins is acquired by TEM-1 and OXA-1 ; Cephamycin resistance is generated by AmpC-Lactamase (CMY) and resistance to broad-spectrum cephalosporins is conferred by ESBL ( Husna et al, 2023 ).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Exploring of spectrum beta lactamase producing multidrug-resistant Salmonella enterica serovars in goat meat markets of Bangladesh

Naser,

Hossain,

Chowdhury

et al. 2024

Veterinary and Animal Science

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Exploring of spectrum beta lactamase producing multidrug-resistant Salmonella enterica serovars in goat meat markets of Bangladesh

Naser,

Hossain,

Chowdhury

et al. 2024

Veterinary and Animal Science

View full text Add to dashboard Cite

Extended-spectrum β-lactamase-producing bacteria and their resistance determinants in different wastewaters and rivers in Nepal

Khanal,

K C,

Joshi

et al. 2024

Journal of Hazardous Materials

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Evaluation of three protocols for direct susceptibility testing for gram negative-Enterobacteriaceae from patient samples in Uganda with SMS reporting

Aruhomukama,

Magiidu,

Katende

et al. 2024

Sci Rep

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In Uganda, the challenge of generating and timely reporting essential antimicrobial resistance (AMR) data has led to overreliance on empirical antibiotic therapy, exacerbating the AMR crisis. To address this issue, this study aimed to adapt a one-step AMR testing protocol alongside an SMS (Short Message Service) result relay system (SRRS), with the potential to reduce the turnaround time for AMR testing and result communication from 4 days or more to 1 day in Ugandan clinical microbiology laboratories. Out of the 377 samples examined, 54 isolates were obtained. Notably, E. coli (61%) and K. pneumoniae (33%) were the most frequently identified, majority testing positive for ESBL. Evaluation of three AMR testing protocols revealed varying sensitivity and specificity, with Protocol A (ChromID ESBL-based) demonstrating high sensitivity (100%) but no calculable specificity, Protocol B (ceftazidime-based) showing high sensitivity (100%) and relatively low specificity (7.1%), and Protocol C (cefotaxime-based) exhibiting high sensitivity (97.8%) but no calculable specificity. ESBL positivity strongly correlated with resistance to specific antibiotics, including cefotaxime, ampicillin, and aztreonam (100%), cefuroxime (96%), ceftriaxone (93%), and trimethoprim sulfamethoxazole (87%). The potential of integrating an SRRS underscored the crucial role this could have in enabling efficient healthcare communication in AMR management. This study underscores the substantial potential of the tested protocols for accurately detecting ESBL production in clinical samples, potentially, providing a critical foundation for predicting and reporting AMR patterns. Although considerations related to specificity warrant careful assessment before widespread clinical adoption.

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Extended-spectrum β-lactamases producing Enterobacteriaceae (ESBL-PE) prevalence in Nepal: A systematic review and meta-analysis

Cited by 3 publications

References 93 publications

Exploring of spectrum beta lactamase producing multidrug-resistant Salmonella enterica serovars in goat meat markets of Bangladesh

Exploring of spectrum beta lactamase producing multidrug-resistant Salmonella enterica serovars in goat meat markets of Bangladesh

Extended-spectrum β-lactamase-producing bacteria and their resistance determinants in different wastewaters and rivers in Nepal

Evaluation of three protocols for direct susceptibility testing for gram negative-Enterobacteriaceae from patient samples in Uganda with SMS reporting

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