Extended release levodopa at bedtime as a treatment for nocturiain Parkinson's disease: An open label study

Brusa, Livia; Ponzo, Viviana; Ceravolo, Roberto; Palermo, Giovanni; Agrò, Enrico Finazzi; Viselli, F.; Altavista, Maria Concetta; Iani, Cesare; Stocchi, Fabrizio; Stanzione, Paolo

doi:10.1016/j.jns.2019.116625

Cited by 13 publications

(8 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Evaluation of urological function: The International Consultation on Incontinence Questionnaire for Overactive Bladder (ICIQ-OAB) was used to evaluate the severity of lower urinary tract symptoms in patients with PD, including domains related to frequency, urgency, nocturia, and urinary incontinence ( McDonald et al, 2020 ). The International Prostate Symptom Score (IPSS) was also used to evaluate the filling (three items) and voiding (four items) phases in patients with PD ( Brusa et al, 2020 ). For both of these questionnaires, a higher score implied more severe symptoms in the lower urinary tract.…”

Section: Methodsmentioning

confidence: 99%

The Role of the Diaphragm in Postural Stability and Visceral Function in Parkinson’s Disease

Jiang

Zhang

et al. 2021

Front. Aging Neurosci.

View full text Add to dashboard Cite

Background: In normal subjects, the diaphragm plays a key functional role in postural stability, articulation, respiration, defecation, and urination.Objectives: The aim of this study was to investigate the role of the diaphragm in postural stability and visceral function in patients with Parkinson’s disease (PD) and to compare the diaphragm function by gender, Hoehn and Yahr (H&Y) staging, and motor subtypes.Methods: In total, 79 patients were enrolled in this cross-sectional study. The severity of the disease was assessed by the Movement Disorder Society-Unified Parkinson’s Disease Rating Scale III and by H&Y staging. Postural stability was quantitatively recorded, and respiratory function was evaluated by spirometry. Several scales were used to evaluate visceral function in patients with PD. In addition, diaphragm ultrasound was used to measure the excursion, contraction velocity, and thickness of the diaphragm during quiet breathing, deep breathing, and the sniff test. Significant features were selected by the least absolute shrinkage and selection operator (LASSO) regression and fitted in the multivariate linear regression and Pearson’s correlation analysis.Results: Diaphragm thickness and excursion during quiet breathing were significantly different between men and women and between H&Y stage 1–2 and stage 2.5–3, whereas the diaphragm function was not influenced by motor subtypes. It was shown that the diaphragmatic function was significantly correlated with postural stability, voice function, respiratory function, constipation, and urological function to varying degrees in patients with PD.Conclusion: The diaphragmatic function is associated with dysfunction in PD although it remains unclear as to whether the observed changes in the diaphragm are primary or secondary.

show abstract

Section: Methodsmentioning

confidence: 99%

The Role of the Diaphragm in Postural Stability and Visceral Function in Parkinson’s Disease

Jiang

Zhang

et al. 2021

Front. Aging Neurosci.

View full text Add to dashboard Cite

show abstract

“…Of the 13 studies (15-27) included, one (21) focused on assessment and 12 (15)(16)(17)(18)(19)(20)(22)(23)(24)(25)(26)(27) evaluated treatment of nocturia in neurological patients. Participants were recruited through secondary care (Neurology or Urology) in all studies included we identified no studies in primary care.…”

Section: General Characteristics Of Included Studiesmentioning

confidence: 99%

Assessment and Treatment of Nocturia in Neurological Disease in a Primary Care Setting: Systematic Review and Nominal Group Technique Consensus

Merode

Dawson

Coulthard

et al. 2022

European Urology Focus

View full text Add to dashboard Cite

“…Recently, an observational study on 106 patients suggests a benefit of extended-release levodopa at bedtime on nocturia [76].…”

Section: Treatmentmentioning

confidence: 99%

Lower urinary tract dysfunction in Parkinsonian syndromes

et al. 2021

View full text Add to dashboard Cite

Purpose of review:The aim of this review is to outline the clinical presentation, pathophysiology and evaluation of lower urinary tract (LUT) dysfunction in Parkinson's disease and other parkinsonian syndromes including multiple system atrophy, dementia with Lewy bodies, progressive supranuclear palsy and corticobasal degeneration.Recent findings: LUT dysfunction commonly occurs in neurological disorders, including patients with parkinsonian syndromes. The pattern of LUT dysfunction and its severity are variable, depending upon the site of lesion within the neural pathways. Parkinsonian syndromes are broadly divided into Parkinson's disease (PD) and atypical parkinsonian syndromes such as multiple system atrophy (MSA), dementia with Lewy bodies (DLB), progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). Different parkinsonian syndromes have distinct clinical features (e.g., dysautonomia, early dementia, supranuclear gaze palsy, higher corticol signs), and the pattern of LUT dysfunction and its severity can differ.Conclusions: LUT dysfunction is a common feature in patients with parkinsonian syndromes.Recognising the pattern of LUT dysfunction during the assessment of these patients can help management and possibly facilitate an earlier diagnosis.

show abstract

Extended release levodopa at bedtime as a treatment for nocturiain Parkinson's disease: An open label study

Cited by 13 publications

References 16 publications

The Role of the Diaphragm in Postural Stability and Visceral Function in Parkinson’s Disease

The Role of the Diaphragm in Postural Stability and Visceral Function in Parkinson’s Disease

Assessment and Treatment of Nocturia in Neurological Disease in a Primary Care Setting: Systematic Review and Nominal Group Technique Consensus

Lower urinary tract dysfunction in Parkinsonian syndromes

Contact Info

Product

Resources

About