Extended delivery of non-steroidal anti-inflammatory drugs through contact lenses loaded with Vitamin E and cationic surfactants

Torres-Luna, Cesar; Hu, Naiping; Tammareddy, Tejaswi; Domszy, R. C.; Yang, Jeffrey; Wang, Nam Sun; Yang, Arthur

doi:10.1016/j.clae.2019.04.011

Cited by 59 publications

(32 citation statements)

References 27 publications

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“…However, this strategy usually leads to a rapid release of the drug and an initial burst [39]. Several approaches can be used to improve the release behavior, e.g., incorporation into the polymer matrix of ligands or functional monomers with special affinity for the drug, drug-loaded nanoparticles that release the drug in a controlled manner, molecules which act as diffusion barriers to the drug molecules (e.g., vitamin E) or surfactants that interact with the drugs [40][41][42][43].…”

Section: Introductionmentioning

confidence: 99%

Tough and Low Friction Polyvinyl Alcohol Hydrogels Loaded with Anti-inflammatories for Cartilage Replacement

et al. 2020

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The development of new materials that mimic cartilage and its function is an unmet need that will allow replacing the damaged parts of the joints, instead of the whole joint. Polyvinyl alcohol (PVA) hydrogels have raised special interest for this application due to their biocompatibility, high swelling capacity and chemical stability. In this work, the effect of post-processing treatments (annealing, high hydrostatic pressure (HHP) and gamma-radiation) on the performance of PVA gels obtained by cast-drying was investigated and, their ability to be used as delivery vehicles of the anti-inflammatories diclofenac or ketorolac was evaluated. HHP damaged the hydrogels, breaking some bonds in the polymeric matrix, and therefore led to poor mechanical and tribological properties. The remaining treatments, in general, improved the performance of the materials, increasing their crystallinity. Annealing at 150 °C generated the best mechanical and tribological results: higher resistance to compressive and tensile loads, lower friction coefficients and ability to support higher loads in sliding movement. This material was loaded with the anti-inflammatories, both without and with vitamin E (Vit.E) or Vit.E + cetalkonium chloride (CKC). Vit.E + CKC helped to control the release of the drugs which occurred in 24 h. The material did not induce irritability or cytotoxicity and, therefore, shows high potential to be used in cartilage replacement with a therapeutic effect in the immediate postoperative period.

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Section: Introductionmentioning

confidence: 99%

Tough and Low Friction Polyvinyl Alcohol Hydrogels Loaded with Anti-inflammatories for Cartilage Replacement

et al. 2020

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“…Due to their distinct electronic configuration and antifungal properties, novel nanomaterials of lanthanide complexes are pursued for biomedical applications, particularly as drug carriers and/or analyte monitoring (Agarwal et al 2018). When contact lenses containing ophthalmic drug are in contact with eyes, the drug will diffuse and enter the post‐lens tear film, thus extending the residence time of drugs on the eye surface for more than 30 min compared to only 2 min for eye drops and thus improving the drug bioavailability of the cornea (Creech et al 2001; Xu et al 2018; Torres‐Luna et al 2019). Even though the contact lens has some major limitations, such as drug absorption and non‐sustained release, it can often release the ophthalmic drug during the first few hours.…”

Section: Introductionmentioning

confidence: 99%

“…Even though the contact lens has some major limitations, such as drug absorption and non‐sustained release, it can often release the ophthalmic drug during the first few hours. Torres‐Luna et al (2019) reported an extended delivery of the drug, namely improving both the loading capacity and duration of drug release, by incorporating cationic surfactants in vitamin E‐loaded contact lenses. In addition, Yañez et al (2008) demonstrated that semi‐interpenetrating poly(vinylpyrrolidone) (PVP) with poly(hydroxyethyl methacrylate) (pHEMA) can provide a slow release of PVP while keeping the high optical clarity, comfortable and safe contact lenses.…”

Section: Introductionmentioning

confidence: 99%

Design, synthesis and antiamoebic activity of dysprosium‐based nanoparticles using contact lenses as carriers against Acanthamoeba sp.

Kusrini

Sabira

Hashim

et al. 2020

Acta Ophthalmologica

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Purpose Contact lenses have direct contact with the corneal surface and can induce sight‐threatening infection of the cornea known as Acanthamoeba keratitis. The objective of this study was to evaluate the dysprosium‐based nanoparticles (Dy‐based NPs), namely Fe3O4‐PEG‐Dy2O3 nanocomposites and Dy(OH)3 nanorods, as an active component against Acanthamoeba sp., as well as the possibility of their loading onto contact lenses as the drug administering vehicle to treat Acanthamoeba keratitis (AK). Methods The Dy‐based NPs were synthesized, and they were loaded onto commercial contact lenses. The loading content of the NPs and their release kinetics was determined based on the absorbance of their colloidal solution before and after soaking the contact lenses. The cytotoxicity of the NPs was evaluated, and the IC50 values of their antiamoebic activity against Acanthamoeba sp. were determined by MTT colorimetric assay, followed by observation on the morphological changes by using light microscopy. The mechanism of action of the Dy‐based NPs against Acanthamoeba sp. was evaluated by DNA laddering assays. Results The loading efficiencies of the Dy‐based NPs onto the contact lens were in the range of 30.6–36.1% with respect to their initial concentration (0.5 mg ml–1). The Dy NPs were released with the flux approximately 5.5–11 μg cm–2 hr–1, and the release was completed within 10 hr. The emission of the NPs consistently showed a peak at 575 nm due to Dy3+ ion, offering the possible monitoring and tracking of the NPs. The SEM images indicated the NPs are aggregated on the surface of the contact lenses. The DNA ladder assay suggested that the cells underwent DNA fragmentation, and the cell death was due most probably to necrosis, rather than apoptosis. The cytotoxicity assay of Acanthamoeba sp. suggested that Fe3O4‐PEG, Fe3O4‐PEG‐Dy2O3, Dy(NO3)3.6H2O and Dy(OH)3 NPs have an antiamoebic activity with the IC50 value being 4.5, 5.0, 9.5 and 22.5 μg ml–1, respectively. Conclusions Overall findings in this study suggested that the Dy‐based NPs can be considered as active antiamoebic agents and possess the potential as drugs against Acanthamoeba sp. The NPs could be loaded onto the contact lenses; thus, they can be potentially utilized to treat Acanthamoeba keratitis (AK).

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“…However, a major limitation of contact lenses in drug delivery is that most of the drug absorbed in the contact lens is released within the first few hours which limits the use for extended release [9]. Several methods have been employed to increase the release duration of drugs, including nanoparticle-based contact lenses [10], biomimetic and imprinted contact lenses [11], layer-structured contact lenses [12], and lenses with vitamin E diffusion barriers [3,4,8,9,13,14]. A limited number of these approaches were examined in clinical trials such as the treatment of ocular allergy with ketotifen [15] and the treatment of glaucoma with timolol and dorzolamide [16].…”

Section: Introductionmentioning

confidence: 99%

Effect of a Cationic Surfactant on Microemulsion Globules and Drug Release from Hydrogel Contact Lenses

Torres-Luna

Koolivand

et al. 2019

Pharmaceutics

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The present study evaluates the in vitro release of diclofenac sodium (DFNa) from contact lenses based on poly-2-hydroxyethyl methacrylate (pHEMA) hydrogels containing an embedded microemulsion to extend release duration. The oil (ethyl butyrate)-in-water microemulsion systems are prepared with two non-ionic surfactants, Brij 97 or Tween 80, together with a long-alkyl chain cationic surfactant, cetalkonium chloride (CKC). Without CKC, Brij 97 or Tween 80-based microemulsions showed average droplet sizes of 12 nm and 18 nm, respectively. The addition of CKC decreased the average droplet sizes to 2–5 nm for both non-ionic surfactants. Such significant reduction in the average droplet size corresponds to an increase in the DFNa release duration as revealed by the in vitro experiments. Contact lens characterization showed that important properties such as optical transparency and water content of Brij 97-based contact lenses with cationic microemulsions was excellent. However, the optical transparency of the corresponding Tween 80 based contact lenses was unsatisfactory. The results indicate that cationic microemulsion-laden contact lenses can benefit from combinatory effects of microemulsions and cationic surfactant at low CKC weight percentage, e.g., with the release of 70% of the drug in 45, 10, and 7 h for B97-CKC-0.45%, CKC-0.45%, and control lenses, respectively. However, the microemulsion effect on extending DFNa release became negligible at the highest CKC weight percentage (1.8%).

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Extended delivery of non-steroidal anti-inflammatory drugs through contact lenses loaded with Vitamin E and cationic surfactants

Cited by 59 publications

References 27 publications

Tough and Low Friction Polyvinyl Alcohol Hydrogels Loaded with Anti-inflammatories for Cartilage Replacement

Tough and Low Friction Polyvinyl Alcohol Hydrogels Loaded with Anti-inflammatories for Cartilage Replacement

Design, synthesis and antiamoebic activity of dysprosium‐based nanoparticles using contact lenses as carriers against Acanthamoeba sp.

Effect of a Cationic Surfactant on Microemulsion Globules and Drug Release from Hydrogel Contact Lenses

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