2009
DOI: 10.1007/s12640-009-9133-y
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Abstract: 2,4-Dinitrophenol (DNP) is classically known as a mitochondrial uncoupler and, at high concentrations, is toxic to a variety of cells. However, it has recently been shown that, at subtoxic concentrations, DNP protects neurons against a variety of insults and promotes neuronal differentiation and neuritogenesis. The molecular and cellular mechanisms underlying the beneficial neuroactive properties of DNP are still largely unknown. We have now used DNA microarray analysis to investigate changes in gene expressio… Show more

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Cited by 17 publications
(12 citation statements)
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“…This scaffolding effect can be construed as analogous to formation of focal contacts, but with pathogenic consequences when AβOs become attached. Not only Ca 2+ but cAMP levels [24, 156] could be disrupted. It is intriguing that once neurons have reached a fully differentiated state, PrP can enzymatically be removed with little or no impact on AβO accumulation in hot spots and synapses [180].…”
Section: Transduction Mechanismmentioning
confidence: 99%
“…This scaffolding effect can be construed as analogous to formation of focal contacts, but with pathogenic consequences when AβOs become attached. Not only Ca 2+ but cAMP levels [24, 156] could be disrupted. It is intriguing that once neurons have reached a fully differentiated state, PrP can enzymatically be removed with little or no impact on AβO accumulation in hot spots and synapses [180].…”
Section: Transduction Mechanismmentioning
confidence: 99%
“…Indeed, the target of chemical uncouplers such as DNP is not a protein, but is instead the mitochondrial membrane where they transfer protons to the matrix [13]. Although DNP’s initial uncoupling action is non-genomic, several prominent signaling cascades involved in adaptive neuroplasticity and stress resistance are activated including those involving calcium and cyclic AMP, and downstream kinases and transcription factors (Figure 2) [56, 97]. …”
Section: The Phoenix Of Uncoupling Agents: Development Of Dnp As a Nementioning
confidence: 99%
“…Studies in animals and humans show decreased neurogenesis in the hippocampus with age [69]. Synaptic plasticity also is dependent on the regulation of neurite outgrowth (neuritogenesis) [10, 11]. …”
Section: Introductionmentioning
confidence: 99%