2013
DOI: 10.1371/journal.pone.0076131
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Expression Patterns of the Drosophila Neuropeptide CCHamide-2 and Its Receptor May Suggest Hormonal Signaling from the Gut to the Brain

Abstract: The insect neuropeptides CCHamide-1 and -2 are recently discovered peptides that probably occur in all arthropods. Here, we used immunocytochemistry, in situ hybridization, and quantitative PCR (qPCR), to localize the two peptides in the fruitfly Drosophila melanogaster. We found that CCHamide-1 and -2 were localized in endocrine cells of the midgut of larvae and adult flies. These endocrine cells had the appearance of sensory cells, projecting processes close to or into the gut lumen. In addition, CCHamide-2 … Show more

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Cited by 49 publications
(60 citation statements)
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“…CCHamide-2 could act directly on the sensory neurons expressing sugar receptors to have such an effect, and it has recently been shown to act directly on the insulin producing cells in the brain [44]. Though the gut is a likely source of hormonal CCHamide-2 here, this is not entirely clear since also CCHamide-2-expressing neurons [24] might be involved.…”
Section: Functions Of Insect Epsmentioning
confidence: 99%
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“…CCHamide-2 could act directly on the sensory neurons expressing sugar receptors to have such an effect, and it has recently been shown to act directly on the insulin producing cells in the brain [44]. Though the gut is a likely source of hormonal CCHamide-2 here, this is not entirely clear since also CCHamide-2-expressing neurons [24] might be involved.…”
Section: Functions Of Insect Epsmentioning
confidence: 99%
“…Alternatively (secretory) neurons and EEs expressing the same brain-EP may be simultaneously active or even activate each other to coordinately affect both brain and gut. A hormonal action of EPs on the brain has been suggested [24] and clearly is to be expected [27], but could so far not been fully demonstrated. In contrast, peptide effects on gut motility or enzyme secretion are well documented (see below).…”
Section: Chemical Identity Of Insect Eps and Possible Release Modesmentioning
confidence: 99%
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“…A novel signal CCHa2, which is discussed above for its role in regulating Dilp levels in adult brain, has also been found to be an important component of brain–gut signaling pathway in larvae. For example, Li et al reported the exciting observation that the brain receives feed-induced CCHa2 from gut endocrine cells through its receptor (Li S. et al, 2013). Furthermore, another study by Ren et al has shown that food intake is regulated by CCHa2 in larval brain (Ren et al, 2015).…”
Section: Links Between Larval Organsmentioning
confidence: 99%