Expression patterns common and unique to ulcerative colitis and celiac disease

Abstract

Autoimmune diseases like celiac disease (CeD) and ulcerative colitis (UC) show a common genetic background defined by the existence of shared susceptibility loci. We aimed to go deeper into this common genetic background through performing a cross-disease study based on gene expression. We measured the expression of 21 genes located in 13 CeD-UC susceptibility regions, and 10 genes in five CeD risk regions. Determinations were carried out in colon/rectum samples from 13 UC patients (inflamed and uninflamed tissue) and four colon samples from controls. Duodenal samples from 19 CeD patients and 12 controls were used for comparisons. Differences were analyzed using the Bayesian method. The shared chromosomal regions containing TNFAIP3, PTPN2, ICOSLG, C1orf106, and IL21 showed similar results in both diseases. FASLG, PLEK, CCR4, and TAGAP, all located in CeD risk loci, were up-regulated in both CeD and UC patients. Finally, ZFP36L1, ZMIZ1, PUS10, UBE2L3, and BACH2 showed opposite results in CeD and UC. A high complexity underlies autoimmune common susceptibility loci, as the expression pattern of the studied genes does not always correlate with the one expected attending to the apparent genetic background. Differentially expressed genes such as ZFP36L1, ZMIZ1, PUS10, and BACH2 deserve further research in autoimmune diseases. K E Y W O R D Sassociation signals, autoimmune diseases, candidate genes, disease susceptibility, gene expression 86

The Bidirectional Association between Inflammatory Bowel Disease and Atopic Dermatitis: A Systematic Review and Meta-Analysis

“…Current experimental data suggested that 5 IBD risk loci, which incorporated genes important for adaptive immune regulation (IL1RL1/IL18R1/IL18RAP, RTEL1/TNFRSF6B, STAT3, and IL2/IL21) and tissue response (LRRC32), were significantly associated with AD [31]. Intriguingly, investigators revealed that AD symptoms in BALB/c mice were alleviated by antagonizing C-C motif chemokine receptor 4 (CCR4), which was significantly increased in UC patients, as well [34][35][36]. Additionally, there are strong signs that C-C motif ligand 17 (CCL17), the chemokine…”

Biomarkers of Inflammation and Intestinal Mucosa Pathology in Celiac Disease

“…The expressions of selected biomarkers in other inflammatory conditions of the small intestine should be investigated, and it would be very interesting to determine which pathways are shared and which are disease specific. In a study of CD and ulcerative colitis, expressions of genes in shared genetic susceptibility loci and specific CD risk loci were investigated and revealed both common and opposite expression patterns in the two diseases 181 .…”

“…The efforts made by us and others to characterise gene expression in CD could be summarised into a biomarker profile, based on single biomarkers and/or biological processes, to facilitate CD diagnostics. However, the loss of visualisation compared to the histopathologic assessment is one issue when it comes to gene expression analysis in intestinal biopsies, another is, as mentioned, that gene expression in other diseases of the gastrointestinal tract could show partly the same profile both in the intestine and blood 181 . The need for a reference population to compare with individual gene expressions could make it difficult to implement the method clinically.…”

Nanogels of a Succinylated Glycol Chitosan-Succinyl Prednisolone Conjugate: Release Behavior, Gastrointestinal Distribution, and Systemic Absorption

“…(1) SP did not react with SA in a similar reaction condition. (2) The PD concentration in the ultrafiltrate was not changed after the further 24 h incubation of the ultrafiltrate. (3) After the ultrafiltrate was treated in 0.1 M NaOH, the PD concentration did not increase.…”

“…Although the etiology of ulcerative colitis (UC) remains unclear [1], it is regarded as an autoimmune disease. Additionally, UC is induced by genetic factors or is inherited [2]; however, behavioral and environmental factors also appear to contribute to its onset. UC is a chronic relapsing disease that causes colonic inflammation and complications [3][4][5][6].…”