Expression pattern of the drm/gremlin gene during chicken embryonic development

Bardot, Boris; Lecoin, Laure; Huillard, Emmanuelle; Calothy, Georges; Marx, Maria

doi:10.1016/s0925-4773(00)00571-2

Cited by 23 publications

(23 citation statements)

References 10 publications

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“…Drm binds BMP-2 and BMP-4 and controls outgrowth, chondrogenesis and apoptosis during chicken and mouse limb development (Capdevila et al, 1999;Merino et al, 1999;Zuniga et al, 1999). We and others have previously shown that drm displays a dynamic expression pattern during limb buds, branchial arches, dermatome and feather bud development (Merino et al, 1999;Bardot et al, 2001;Ohyama et al, 2001 (Fig. 1 A,B).…”

Section: Drm/gremlin Is Expressed In the Dermis Before Feather Bud Fomentioning

confidence: 73%

“…The drm / gremlin gene is expressed in dermal cells from early stages of dermal precursor formation in the somite (Bardot et al, 2001; and this work) to dense dermis and feather pattern formation.…”

Section: Drm/gremlin Expression In Dermal Cells Is Complementary To Tmentioning

confidence: 90%

“…We have previously reported that during early stages of chicken development drm/gremlin is expressed in the dermomyotome (Bardot et al, 2001). Analysis of expression pattern of drm/ gremlin during feather development from the stage of ectodermal placode formation onwards pattern in the developing skin differs significantly from that of follistatin.…”

Section: Drm/gremlin Is Expressed In the Dermis Before Feather Bud Fomentioning

confidence: 95%

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Drm/Gremlin, a BMP antagonist, defines the interbud region during feather development.

Bardot

Lecoin²,

Fliniaux³

et al. 2004

Int. J. Dev. Biol.

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The pattern of feather buds in a tract is thought to result from the relative ratios between activator and inhibitor signals through a lateral inhibition process. We analyse the role of Drm/Gremlin, a BMPs antagonist expressed during feather pattern formation, in the dermal precursor, the dense dermis, the interbud dermis and in the posterior dermal condensation. We have altered the activity of Drm in embryonic chick skin using retroviral vectors expressing drm/ gremlin and bmps. We show that expression of endogenous drm is under the control of a feedback loop induced by the BMP pathway, and that overexpression of drm results in fusion between adjacent feather buds. We propose that endogenous BMP proteins induce drm expression in the interbud dermis. In turn, the Drm/Gremlin protein limits the inhibitory effect of BMPs, allowing the adjacent row of feathers to form. Thus, the balance between BMPs and its antagonist Drm would regulate the size and spacing of the buds.

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Section: Drm/gremlin Is Expressed In the Dermis Before Feather Bud Fomentioning

confidence: 73%

Section: Drm/gremlin Expression In Dermal Cells Is Complementary To Tmentioning

confidence: 90%

Section: Drm/gremlin Is Expressed In the Dermis Before Feather Bud Fomentioning

confidence: 95%

See 1 more Smart Citation

Drm/Gremlin, a BMP antagonist, defines the interbud region during feather development.

Bardot

Lecoin²,

Fliniaux³

et al. 2004

Int. J. Dev. Biol.

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“…In Xenopus, Drm/Gremlin seems to participate in neural crest induction and patterning (Hsu et al, 1998), whereas in chicken and mouse, it regulates limb bud and lung proximodistal patterning by controlling chondrogenesis, outgrowth, and programmed cell death (Merino et al, 1999;Zuniga et al, 1999;Lu et al, 2001;Shi et al, 2001). However, by comparing the expression pattern of drm in chicken embryo, with those described in Xenopus (Hsu et al, 1998) and mouse (Pearce et al, 1999), we showed significant spaciotemporal differences, which suggested additional roles in different embryonic compartments (Bardot et al, 2001). Our results also suggested that Drm could play a role in adult tissues.…”

Section: Introductionmentioning

confidence: 61%

“…The following constructs were used to generate antisense riboprobes: pBKS/cBMP2 and pBKS/cBMP4 kindly provided by A.H Monsoro-Burq, pCR2.1/cdrm previously described (Bardot et al, 2001), pBSK/cBMP7 kindly provided by A. Lassar, and pBKS/c-noggin kindly provided by D.…”

Section: In Situ Hybridisationmentioning

confidence: 99%

Localized expression of drm/gremlin in the central nervous system of the chicken embryo

Huillard

Marx

2004

Developmental Dynamics

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Drm/Gremlin is a member of the Dan family of bone morphogenetic protein (BMP) antagonists known to function in vertebrate limb outgrowth and lung morphogenesis. Its expression detected in neurons and astrocytes of the adult brain suggested a possible role in brain morphogenesis and/or neuronal versus glial differentiation. To investigate this role, we analysed its expression pattern in the central nervous system of the chicken embryo, by in situ hybridization. In the brain, we found that drm is mainly expressed in the medial pallium in the dorsal telencephalon and in the ventral diencephalon. drm was detected in the meninges of the spinal cord. We also found that drm was expressed in the developing optic nerve and at the optic nerve/pecten junction. In all these territories, distinct bmps are expressed. Taken together, these data suggest that Drm could play a role in the development of the medial pallium and during optic nerve and pecten development by modulating BMP signaling. Developmental Dynamics 229: 688 -694, 2004.

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The neural crest, A multifaceted structure of the vertebrates

Dupin

Douarin

2014

Birth Defects Research Pt C

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In this review, several features of the cells originating from the lateral borders of the primitive neural anlagen, the neural crest (NC) are considered. Among them, their multipotentiality, which together with their migratory properties, leads them to colonize the developing body and to participate in the development of many tissues and organs. The in vitro analysis of the developmental capacities of single NC cells (NCC) showed that they present several analogies with the hematopoietic cells whose differentiation involves the activity of stem cells endowed with different arrays of developmental potentialities. The permanence of such NC stem cells in the adult organism raises the problem of their role at that stage of life. The NC has appeared during evolution in the vertebrate phylum and is absent in their Protocordates ancestors. The major role of the NCC in the development of the vertebrate head points to a critical role for this structure in the remarkable diversification and radiation of this group of animals.

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Expression pattern of the drm/gremlin gene during chicken embryonic development

Cited by 23 publications

References 10 publications

Drm/Gremlin, a BMP antagonist, defines the interbud region during feather development.

Drm/Gremlin, a BMP antagonist, defines the interbud region during feather development.

Localized expression of drm/gremlin in the central nervous system of the chicken embryo

The neural crest, A multifaceted structure of the vertebrates

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