2010
DOI: 10.1128/jb.00916-10
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Abstract: The [2Fe-2S]-containing transcription factor SoxR is conserved in diverse bacteria. SoxR is traditionally known as the regulator of a global oxidative stress response in Escherichia coli, but recent studies suggest that this function may be restricted to enteric bacteria. In the vast majority of nonenterics, SoxR is predicted to mediate a response to endogenously produced redox-active metabolites. We have examined the regulation and function of the SoxR regulon in the model antibiotic-producing filamentous bac… Show more

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Cited by 36 publications
(51 citation statements)
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References 52 publications
(69 reference statements)
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“…Five of these are previously confirmed members of the S. coelicolor SoxR regulon [5], [6]. Of the newly identified SoxR-induced genes, it appeared that SCO0320 (homologous to the carboxy-terminal half of SLI_0274, a quinone oxidoreductase in Streptomyces lividans , Figure S2 ) and SCO0321 (carboxylesterase) may be transcriptionally coupled.…”
Section: Resultsmentioning
confidence: 77%
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“…Five of these are previously confirmed members of the S. coelicolor SoxR regulon [5], [6]. Of the newly identified SoxR-induced genes, it appeared that SCO0320 (homologous to the carboxy-terminal half of SLI_0274, a quinone oxidoreductase in Streptomyces lividans , Figure S2 ) and SCO0321 (carboxylesterase) may be transcriptionally coupled.…”
Section: Resultsmentioning
confidence: 77%
“…The absence of a soxS homolog and the predicted SoxR regulons in non-enterics has given rise to the notion that SoxR does not regulate a generalized oxidative stress response in the majority of bacteria. This has been corroborated for Pseudomonas putida, P. aeruginosa, and S. coelicolor, where deletion of soxR does not result in increased sensitivity to redox-cycling drugs when compared to the parental strain [5], [9], [15], [16]. While the function of SoxR in P. putida remains unknown, SoxR regulates gene expression in response to redox-active endogenously produced antibiotics in both P. aeruginosa and S. coelicolor, indicating that SoxR plays a role that is intimately tied in with the physiology of these organisms [5], [6], [9], [17], [18].…”
Section: Introductionmentioning
confidence: 73%
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“…Like IscR and NsrR, SoxR belongs to the Rrf2 family of winged helix-turn-helix regulators, whose function is modulated based on the coordination of an Fe-S cluster. Coordination of the [2Fe-2S] cluster occurs through a conserved sequence, CysX2CysXCysX5Cys, in the carboxy-terminus of SoxR homologs in E. coli, P. aeruginosa , and Streptomyces coelicolor 175-177 . SoxR activity is distinct from that of IscR and NsrR in that it functions as a regulator solely when the [2Fe-2S] cluster is in the oxidized form as a result of exposure to the superoxide anion O 2 •-178 .…”
Section: Iron-sulfur Cluster Regulators and Their Role In Bacterial Pmentioning
confidence: 99%
“…In other bacteria, SoxR alone has been shown to directly regulate a small set of genes 183 . While SoxRS of Enterobacteriaceae seem to play a role in protection against exogenous redox-cycling compounds, SoxR of P. putida, P. aeruginosa , and S. coelicolor are believed to protect against endogenously generated antibiotics 175, 177, 184-188 .…”
Section: Iron-sulfur Cluster Regulators and Their Role In Bacterial Pmentioning
confidence: 99%