2013
DOI: 10.1155/2013/250435
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Considering that downregulation of HLA expression could represent a potential mechanism for breast carcinogenesis and metastasis, the aim of the present study was to use immunohistochemical methods to analyze the expression of HLA-Ia, HLA-DR, HLA-DQ, HLA-E, and HLA-G in invasive ductal carcinoma (IDC) of the breast and to relate this HLA profile to anatomopathological parameters. Fifty-two IDC from breast biopsies were stratified according to histological differentiation (well, moderately, and poorly different… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

3
42
0
1

Year Published

2014
2014
2023
2023

Publication Types

Select...
8
1

Relationship

0
9

Authors

Journals

citations
Cited by 56 publications
(46 citation statements)
references
References 40 publications
3
42
0
1
Order By: Relevance
“…Interestingly, we did find a trend towards more HLA-A complete loss in primary SCC tumors compared to primary AC tumors, which was also observed in the LNs and supported by another study in cervical cancer patients [42]. In addition, complete loss of HLA-A was associated with larger tumors in both SCC and AC, which is consistent with a study in breast cancer reporting that larger tumors manifest with low HLA class I expression [44]. …”
Section: Discussionsupporting
confidence: 91%
See 1 more Smart Citation
“…Interestingly, we did find a trend towards more HLA-A complete loss in primary SCC tumors compared to primary AC tumors, which was also observed in the LNs and supported by another study in cervical cancer patients [42]. In addition, complete loss of HLA-A was associated with larger tumors in both SCC and AC, which is consistent with a study in breast cancer reporting that larger tumors manifest with low HLA class I expression [44]. …”
Section: Discussionsupporting
confidence: 91%
“…This phenomenon has been also observed in other tumor types, like breast-, lung-, and liver carcinomas [43, 44]. This is likely resulting in a decreased sensitivity to T cell lysis, which is supported by the observed significant correlation between HLA class I downregulation and a decrease in tumor-infiltrating CD8 + T cells [27, 45], with particularly lower numbers of CD8 + T cells in primary tumors with weak HLA-A expression [21].…”
Section: Discussionsupporting
confidence: 61%
“…Among these studies, there is a high frequency of tumor cell-surface HLA-G expression with an absence in healthy tissue, and increased sHLA-G levels has been detected in various body fluids in a variety of cancers (14). Expression of HLA-G was found to be correlated with clinical parameters such as more advanced disease stage, tumor metastasis and/or with a worse prognosis in tumor patients, indicating that HLA-G could facilitate tumor immune escape, invasiveness and metastasis; thereby HLA-G expression was found to be associated with advanced clinical stage and disease progression and HLA-G expression was also documented as an unfavorable prognostic factor for many kinds of solid malignancies, including breast cancer (59)(60)(61)(62)(63)(64), colorectal cancer (65,66), cervical cancer (67,68), endometrial of allogeneic skin graft survival (52). In an immunocompetent HLA-G1 + M8…”
Section: Relevance Of Hla-g Expression In Cancersmentioning
confidence: 99%
“…In breast cancer high levels of expression of HLA-G of around 40% have been found consistently in various studies [6][7][8][9]. In addition, two studies found an association of high expression of this molecule with an unfavorable patient outcome [6,7].…”
Section: Prognostic Value Of Hla-g In Breast Cancer Patientsmentioning
confidence: 81%