Expression of synovial fluid and articular cartilage VIP in human osteoarthritic knee: A new indicator of disease severity?

Jiang, Wei; Gao, Shu‐guang; Chen, Xiaguang; Xu, Xiao-cao; Xu, Mai; Luo, Wei; Tu, Min; Zhang, Fang‐Jie; Zeng, Chao; Lei, Guanghua

doi:10.1016/j.clinbiochem.2012.08.020

Cited by 28 publications

(38 citation statements)

References 24 publications

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“…These receptors belong to family 2 of the G protein–coupled receptors and elicit remarkable anti-inflammatory and immune-modulatory properties by up-regulating cyclic adenosine 5’-phosphate (cAMP), adenylate cyclase and phospholipase C (PLC) [2, 9]. VPAC receptors are expressed in macrophages as well as in lymphocytes among which VPAC1 is thought to be the major receptor type present during early culture period while VPAC2 is expressed relatively late during macrophage/monocyte activation as an inducible receptor after T cell receptor triggering or LPS stimulation.…”

Section: Reviewmentioning

confidence: 99%

“…In most of the studies, VIP functions in joint protection were performed in RA model; however, the protective function in the progression of OA is uncertain. Jiang et al [2] suggested in their study that VIP may play a protective role in progression of OA just like in RA, as the expression of VIP in synovial fluid and articular cartilage from patients with OA is negatively associated with progressive joint damage and disease sevrity.…”

Section: Reviewmentioning

confidence: 99%

“…The vasoactive intestinal peptide (VIP) also known as the vasoactive intestinal polypeptide is a neuropeptide that belongs to a glucagon/secretin superfamily, the ligand of class II G protein-coupled receptors [1, 2]. It was initially reported to be expressed in lung and small intestine tissue; however, currently it is also described in neurons of central nervous system (CNS) [3, 4].…”

Section: Introductionmentioning

confidence: 99%

“…It shows the therapeutic function in rheumatoid arthritis (RA); however, the protective function of VIP in the progression of OA is not fully explained [2, 17]. In this review, we have focused on the association of VIP in the development and progression of OA and the potential effects of VIP as a therapeutic agent for the treatment of OA.…”

Section: Introductionmentioning

confidence: 99%

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Role of vasoactive intestinal peptide in osteoarthritis

Jiang

Hua

et al. 2016

J Biomed Sci

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Vasoactive intestinal peptide (VIP) plays important roles in many biological functions, such as, stimulation of contractility in the heart, vasodilation, promoting neuroendocrine-immune communication, lowering arterial blood pressure, and anti-inflammatory and immune-modulatory activity. Osteoarthritis (OA) is a chronic and degenerative bone disease, which is one of the most common causes of disability and most common in both sexes as people become older. Interestingly VIP can prevent chronic cartilage damage and joint remodeling. This review article provides update information on the association of VIP and OA and its treatment. Evidences suggest that VIP is down-regulated in synovial fluid of OA, and VIP down-regulation leads to increase in the production of pro-inflammatory cytokines that might contribute to the pathogenesis of OA; however contradictory reports also exist suggesting that accumulation of VIP in joints can also contribute OA. A number of studies indicated that up-regulation of VIP can counteract the action of pro-inflammatory stimuli and alleviate the pain in OA. More clinical investigations are necessary to determine the biology of VIP and its therapeutic potential in OA that might represent the future standards of care for OA.

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Section: Reviewmentioning

confidence: 99%

Section: Reviewmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Role of vasoactive intestinal peptide in osteoarthritis

Jiang

Hua

et al. 2016

J Biomed Sci

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“…All the sections were examined using a Motic BA210 microscope (Motic Instruments, Xiamen, China) at x100 magnification. The relative WIF-1 distribution of cartilage tissue was visualized and quantified using optical density (OD) values (16,17). Positive WIF-1 immunostaining was defined as detectable immunoreactivity in the perinuclear and/or other cytoplasmic regions in chondrocytes.…”

Section: Methodsmentioning

confidence: 99%

Association between Wnt inhibitory factor-1 expression levels in articular cartilage and the disease severity of patients with osteoarthritis of the knee

Gao

Zeng

Liu

et al. 2016

Experimental and Therapeutic Medicine

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Pathological role of fibroblast‐like synoviocytes in charcot neuroarthropathy

Molligan

Barr

Mitchell

et al. 2015

Journal Orthopaedic Research

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This study was designed to characterize the synovium in the joints of Charcot neuroarthropathy (CNA) and investigate the potential role of fibroblast-like synoviocytes (FLS) in the pathology of CNA. Synovial samples were collected from CNA patients (n ¼ 7) and non-CNA patients (n ¼ 7), for control, during orthopaedic procedures and used for histology and isolation of FLS. Histological characterization of synovium included innervation and FLS localization. The isolated FLS from the CNA and non-CNA synovium were cultured, with or without tumor necrosis factor-a (TNF-a), for evaluation of invasiveness, gene expression, and cartilage degradation. Vasoactive intestinal peptide (VIP), a neuropeptide, was supplemented into the co-cultures of FLS and cartilage explants. Compared with the non-CNA synovium, CNA synovium was highly inflammatory, with reduced innervation and intense expression of cadherin-11. The FLS isolated from CNA synovium, particularly when activated with TNF-a, were more invasive, increased the expression of ADAMTS4, IL-6, and RANKL, and depleted proteoglycans from cartilage explants when they were co-cultured. Addition of VIP into the culture medium neutralized the catabolic effect of the CNA FLS on cartilage explants. In conclusion, FLS plays an important role in the pathology of CNA. Therapies targeting synovium and FLS may prevent or treat the joint destruction in CNA.

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Expression of synovial fluid and articular cartilage VIP in human osteoarthritic knee: A new indicator of disease severity?

Cited by 28 publications

References 24 publications

Role of vasoactive intestinal peptide in osteoarthritis

Role of vasoactive intestinal peptide in osteoarthritis

Association between Wnt inhibitory factor-1 expression levels in articular cartilage and the disease severity of patients with osteoarthritis of the knee

Pathological role of fibroblast‐like synoviocytes in charcot neuroarthropathy

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