Expression of sulfoglucuronyl (HNK-1) carbohydrate and its binding protein (SBP-1) in developing rat cerebellum

Zhao, Zezhou; Chou, Denise K. H.; Nair, S.M; Tobet, Stuart A.; Jungalwala, Firoze B.

doi:10.1016/s0165-3806(00)00007-9

Cited by 18 publications

(58 citation statements)

References 53 publications

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“…velopment after cell migration was complete is consistent with the notion that biochemical interaction and signaling could occur between the two during the cell migration process. Similar localization and expression patterns of SBP-1 and SGC were also seen in the developing rat cerebellum for granule neuron migration from the external granule cell layer to internal granule cell layer (Zhao et al, 2000).…”

Section: Localization Of Sbp-1 In Neurons and Sgc In Cellular Processsupporting

confidence: 63%

“…Our immunocytochemical studies during development of both cerebral cortex and cerebellum (Zhao et al, 2000) showed down regulation of interacting molecules SBP-1 and SGC after neuronal migration was complete. The immunocytochemical observations paralleled previous biochemical analysis (Prasadarao et al, 1990;Chou et al, 1991;Nair and Jungalwala, 1997).…”

Section: Localization Of Sbp-1 and Sgc In Dissociated Cell Culturesmentioning

confidence: 62%

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Expression and role of sulfoglucuronyl (HNK-1) carbohydrate and its binding protein SBP-1 in developing rat cerebral cortex

et al. 2000

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Section: Localization Of Sbp-1 In Neurons and Sgc In Cellular Processsupporting

confidence: 63%

Section: Localization Of Sbp-1 and Sgc In Dissociated Cell Culturesmentioning

confidence: 62%

Expression and role of sulfoglucuronyl (HNK-1) carbohydrate and its binding protein SBP-1 in developing rat cerebral cortex

et al. 2000

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“…HMGB1 was present both in nuclei and on plasma membranes, HMGB1/2 disappears almost completely by postnatal day 3. In the cerebellum HMGB1/2 is strongly expressed shortly after birth in the granule neurons of the external and internal granule cell layers [31]. Again, HMGB1/2 is present both in nuclei and on plasma membranes.…”

Section: Expression In the Nervous Systemmentioning

confidence: 99%

Regulated expression and subcellular localization of HMGB1, a chromatin protein with a cytokine function

Müller

Ronfani

Bianchi

2004

Journal of Internal Medicine

324

249

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“…Due to a strong promoter, HMGB1 can be transcribed at extremely high levels, however, a silencer element upstream of the promoter holds HMGB1 transcription at a basal stage under normal conditions (3). Although the expression of HMGB1 is under strict developmental control (4,5) and essential for animal survival (6), HMGB1 is apparent in several mature cells (7)(8)(9) as well as in transformed cells (10,11). In cancer cells, HMGB1 supports cell transformation, growth and cellular resistance (11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

Fibroblasts mediate induction of high mobility group box protein 1 in lung epithelial cancer cells by diffusible factors

Bartling

Fuchs²,

Silber³

et al. 2007

Int J Mol Med

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Abstract. Cancer development is associated with the high mobility group box protein 1 (HMGB1), which modulates the transcriptional activity in the nucleus, but it is also present in the cytoplasm and outside the cell in certain conditions. As the progression of lung cancer is supported by mitogenic stimuli of stromal fibroblasts, we studied the impact of lung fibroblasts (WI-38) on the expression and localization of HMGB1 in lung epithelial cancer cells (H358). HMGB1 was mainly localized in the nucleus of non-mitotic H358 cells but highly distributed in the cytoplasm of mitotic cells. Conditioned medium (CM) from WI-38 fibroblasts enhanced the expression of HMGB1 at the mRNA and protein level compared to the control CM from H358 cells. In particular, the amount of cytoplasmic HMGB1 was elevated in response to fibroblast CM, which was reduced by inhibiting the basic fibroblast growth factor with blocking antibodies. Although cytoplasmic HMGB1 can be released from the cell, we did not determine a significant amount of extracellular HMGB1 in these conditions. This might partially be based on the sensitivity of HMGB1 to extracellular proteases as CM caused fast proteolysis of the cytoplasmic HMGB1 preparations. Our data suggest that diffusible factors of fibroblasts support the biological function of cancer cells via HMGB1 activation.

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Expression of sulfoglucuronyl (HNK-1) carbohydrate and its binding protein (SBP-1) in developing rat cerebellum

Cited by 18 publications

References 53 publications

Expression and role of sulfoglucuronyl (HNK-1) carbohydrate and its binding protein SBP-1 in developing rat cerebral cortex

Expression and role of sulfoglucuronyl (HNK-1) carbohydrate and its binding protein SBP-1 in developing rat cerebral cortex

Regulated expression and subcellular localization of HMGB1, a chromatin protein with a cytokine function

Fibroblasts mediate induction of high mobility group box protein 1 in lung epithelial cancer cells by diffusible factors

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