2000
DOI: 10.1016/s0925-4773(99)00288-9
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Abstract: The Drosophila sprouty protein is a recently-identified intracellular modulator of FGF and EGF receptor tyrosine kinase activity which antagonises ras/MAP kinase signalling. In a differential display analysis to identify genes involved in patterning the mid/hindbrain region of the chick neural tube, we have identified a sprouty orthologue, sprouty2. Here we report expression of sprouty2 transcripts in the developing chick embryo. We find a close correlation with known sites of FGF activity but little correlati… Show more

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Cited by 115 publications
(74 citation statements)
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“…More specifically, Fgf3 and Fgf8 have pronounced expression in the pharyngeal endoderm and ectoderm, and embryos injected with antisense morpholinos directed against the transcripts of these two genes fail to form pharyngeal cartilages (David et al, 2002;Walshe and Mason, 2003). Other studies have also noted that the mature pharyngeal arches are a prominent site of expression of members of the FGF synexpression group, including the transcriptional effectors pea3 and erm, as well as inhibitors of FGF signaling, such as Pyst1 (MKP3) and sprouty 2 (Munchberg et al, 1999;Chambers and Mason, 2000;Chotteau-Lelievre et al, 2001;Eblaghie et al, 2003;Walshe and Mason, 2003).…”
Section: Resultsmentioning
confidence: 99%
“…More specifically, Fgf3 and Fgf8 have pronounced expression in the pharyngeal endoderm and ectoderm, and embryos injected with antisense morpholinos directed against the transcripts of these two genes fail to form pharyngeal cartilages (David et al, 2002;Walshe and Mason, 2003). Other studies have also noted that the mature pharyngeal arches are a prominent site of expression of members of the FGF synexpression group, including the transcriptional effectors pea3 and erm, as well as inhibitors of FGF signaling, such as Pyst1 (MKP3) and sprouty 2 (Munchberg et al, 1999;Chambers and Mason, 2000;Chotteau-Lelievre et al, 2001;Eblaghie et al, 2003;Walshe and Mason, 2003).…”
Section: Resultsmentioning
confidence: 99%
“…The co-expression of Spry and Sef with known sites of RTK signalling during embryogenesis [21] lends credence to the important role they have in cell fate specification; a close spatial and temporal interdependence between RTK signalling (e.g. FGF signalling) and Spry and Sef gene expression has been seen in many mammalian tissues, including brain, muscle, gut, heart and lung [20,21,27,28]. As a means of providing tight autoregulation, the expression of these inhibitors are induced by the pathway they antagonize; Spry and Sef have been shown to be positively regulated by FGF, more specifically FGF-induced ERK1/2 signalling [18,22,26,29].…”
Section: Introductionmentioning
confidence: 89%
“…Spry proteins are widely conserved, with up to four members identified in mammals (Spry1-4) [19], and are expressed in highly restricted patterns that correlate with known sites of FGF signalling [20,21]. Spry is recognized in many physiological and developmental processes as an antagonist of RTK signalling pathways, with its overexpression mimicking the functional loss of RTKs, including those activated by FGF [22].…”
Section: Introductionmentioning
confidence: 99%
“…Since members of the FGF8 synexpression group are expressed in similar patterns in chick and mouse, it is highly unlikely that general speciesspecific differences in the reception of FGF signals are the reason for the species-specific differences in the Tbx22 patterns (Chambers and Mason, 2000;Roehl and Nusslein-Volhard, 2001;Firnberg and Neubü ser, 2002;Andreou et al, 2007). We have previously shown that during early chicken and mouse facial development, FGF receptor-1 (FGFR1) and at lower levels also FGF receptor-2 (FGFR2) are widely expressed in the facial mesenchyme (Bachler and Neubü ser, 2001;Firnberg and Neubü ser, 2002).…”
Section: Fgf and Bmp Signaling Pathways Converge On The Regulation Ofmentioning
confidence: 99%