2010
DOI: 10.1095/biolreprod.108.074971
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Abstract: SPEF2 is expressed in all ciliated cells and is essential for correct sperm tail development and male fertility. We have previously identified a mutation within the SPEF2 gene as the cause for infertility because of immotile and malformed sperm tails in pigs. This mutation in pigs alters the testis-specific long SPEF2 isoform and exclusively affects the sperm tail development. In infertile boars, axonemal and all accessory structures of the sperm tail are affected; thus, SPEF2 seems to participate in the organ… Show more

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Cited by 68 publications
(84 citation statements)
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“…4c). The immunoreactive pattern of the elongated spermatids was similar to that found in mice (Sironen et al 2010). The IHC revealed SPEF2 protein expression in epithelial cells throughout the bull epididymis, especially in the corpus epididymis.…”
Section: Splice Variant and Methylation Of Spef2supporting
confidence: 76%
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“…4c). The immunoreactive pattern of the elongated spermatids was similar to that found in mice (Sironen et al 2010). The IHC revealed SPEF2 protein expression in epithelial cells throughout the bull epididymis, especially in the corpus epididymis.…”
Section: Splice Variant and Methylation Of Spef2supporting
confidence: 76%
“…The SPEF2 variants exhibited tissue-specific, phage-specific, and species-specific expression. In rats, SPEF2 is expressed in tissues containing cilia-like structures, such as the lungs, trachea, testes, and the brain, at lower levels in the kidneys and spleen, and is not expressed in the heart and liver, which suggest its role in ciliogenesis (Sironen et al 2010). In pigs, the SPEF2 gene is differentially expressed in abnormal and healthy animals.…”
Section: Discussionmentioning
confidence: 99%
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“…In mature murine sperm, SPEF2 was present in the distal part of the sperm tail mid-piece, sertoli cells and germ cells. Further research has showed that the SPEF2 gene had high expression in the tail of elongating spermatids and in the tail of mouse sperm (Sironen et al, 2010). The loss of SPEF2 function in mice resulted in spermatogenesis defects and primary ciliary dyskinesia, which caused a decline in elongating spermatids and faults in the formation of sperm tail (Sironen et al, 2011).…”
Section: Introductionmentioning
confidence: 99%