Expression of sialyl-Tn antigen is correlated with survival time of patients with gastric carcinomas

Xiao, Chun; Terata, Nobukuni; Kodama, Masashi; Jančić, Snežana; Hosokawa, Yu; Hattori, Takanori

doi:10.1016/0959-8049(93)90529-o

Cited by 44 publications

(32 citation statements)

References 10 publications

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“…The finding that sulfomucins decrease and STN increases with tumour progression is consistent with previous reports [12,19,20]. The details of why this occurs remain unclear, although it clearly involves progressive reduction in sulfation of carbohydrate chains during colon carcinogenesis.…”

Section: Discussionsupporting

confidence: 88%

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Reciprocal control of colon-specific sulfomucin and sialosyl-Tn antigen expression in human colorectal neoplasia

et al. 1997

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Histochemical reports claim that sulfomucins decrease and sialylated mucins increase during colon carcinogenesis. We examined the expression of colon-specific sulfomucins and sialosyl Tn antigen (STN) in normal small intestine, normal colorectal mucosa and colorectal tumours at different stages of progression immunohistochemically, using MAb 91.9H specific for colonic sulfomucins and MAb TKH-2 for STN. No expression of sulfomucins recognized by MAb 91.9H was found in normal small intestine, whereas STN staining was pronounced. The converse was the case in normal colorectal mucosa. Sulfomucins were still found in adenomas, but the amounts decreased with depth of invasion in cancers (P < 0.001). In contrast, no STN could be detected in benign lesions, but staining became increasingly evident with invasion (P < 0.001). This reciprocal control of expression of colon-specific sulfomucins and STN evident in tumour progression indicates that the mucous phenotype shifts from the colonic to the small intestinal type.

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Section: Discussionsupporting

confidence: 88%

“…However, it is strongly expressed in a large number of adenocarcinomas, especially those of the stomach, colon and pancreas, and it has been reported that patients with STN-positive tumours have a worse prognosis than those with STN-negative lesions [13,19].…”

Section: Introductionmentioning

confidence: 98%

Reciprocal control of colon-specific sulfomucin and sialosyl-Tn antigen expression in human colorectal neoplasia

et al. 1997

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“…Sialyl Tn is detected in a wide range of cancers including gastric, colorectal, pancreatic, endometrial, breast, and ovarian [102][103][104][105][106][107][108], yet sialyl Tn expression is low or absent in normal epithelial cells [109][110][111][112]. Sialyl Tn expression is associated with metastatic disease, recurrence, and reduced survival rates in breast cancer [98,113], and a negative association between sialyl Tn and survival has been confirmed by many other studies [98,[114][115][116][117][118][119][120]; although this is not a universal finding [121,122]. Approximately 30 % of breast cancers are sialyl Tn positive [123,124] and over 80 % of all carcinomas express either Tn or sialyl Tn structures [125].…”

Section: Sialyl Tn Antigen and Tumor Invasionmentioning

confidence: 78%

Role of Receptor Sialylation in the Ovarian Tumor Cell Phenotype

Bellis¹

2014

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“…In studies evaluating the prognostic impact of STN, some authors described an association with an unfavorable outcome in stage III and IV carcinomas [16,17] whereas others observed a correlation with poor prognosis especially in stage I tumors [15]. Werther et al [13] reported a negative prognostic impact of STN in patients mainly belonging to T3 and T4 stage.…”

Section: Discussionmentioning

confidence: 99%

“…STN has been demonstrated to be significantly associated with an unfavorable prognosis in colorectal [12] as well as gastric carcinomas [13,14]. Additionally, a prognostic importance of STN has been emphasized in stage I [15] and stage III/IV gastric carcinomas [16,17]. Kakeji et al [18] observed an association between lymphatic metastasis and STN expression in Borrmann type IV neoplasms.…”

Section: Introductionmentioning

confidence: 94%

Histopathological Subtypes and Prognosis of Gastric Cancer Are Correlated with the Expression of Mucin-Associated Sialylated Antigens: Sialosyl-Lewis<sup>a</sup>, Sialosyl-Lewis<sup>x</sup> and Sialosyl-Tn

Baldus¹,

Zirbes²,

Mönig³

et al. 1998

Tumor Biol

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The expression of three sialylated mucin-associated antigens – sialosyl-Lewis^a (SLEA), sialosyl-Lewis^x (SLEX) and sialosyl-Tn (STN) – and their correlation with the TNM stage, histopathological growth pattern and prognosis was investigated in a series of 127 gastric carcinomas. Various classification systems (pTNM, WHO and Laurén) did not display any correlation with an expression of the sialomucin antigens under study. SLEA reactivity was strongly associated with an unfavorable outcome of the total population, whereas SLEX and STN did not exert such an impact. However, in the subgroups of pTNM stage I as well as pN0 patients, SLEA and SLEX reactivity of the tumors was associated with a worse prognosis. In the subgroup of diffuse-type cancers as defined according to Laurén’s classification, the expression of all three antigens indicated a worsening of the prognosis.

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Expression of sialyl-Tn antigen is correlated with survival time of patients with gastric carcinomas

Cited by 44 publications

References 10 publications

Reciprocal control of colon-specific sulfomucin and sialosyl-Tn antigen expression in human colorectal neoplasia

Reciprocal control of colon-specific sulfomucin and sialosyl-Tn antigen expression in human colorectal neoplasia

Role of Receptor Sialylation in the Ovarian Tumor Cell Phenotype

Histopathological Subtypes and Prognosis of Gastric Cancer Are Correlated with the Expression of Mucin-Associated Sialylated Antigens: Sialosyl-Lewis<sup>a</sup>, Sialosyl-Lewis<sup>x</sup> and Sialosyl-Tn

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