Expression of CD56 is an unfavorable prognostic factor for acute promyelocytic leukemia with higher initial white blood cell counts

Abstract

Expression of CD56 has recently been introduced as one of the adverse prognostic factors in acute promyelocytic leukemia (APL). However, the clinical significance of CD56 antigen in APL has not been well elucidated. We assessed the clinical significance of CD56 antigen in 239 APL patients prospectively treated with all-trans retinoic acid and chemotherapy according to the Japan Adult Leukemia Study Group APL97 protocol. All patients were prospectively treated by the Japan Adult Leukemia Study Group APL97 protocol. The median follow-up period was 8.5 years. Positive CD56 expression was found in 23 APL patients (9.6%). Expression of CD56 was significantly associated with lower platelet count (P = 0.04), severe disseminated intravascular coagulation (P = 0.04), and coexpression of CD2 (P = 0.03), CD7 (P = 0.04), CD34 (P < 0.01) and/or human leukocyte antigen-DR (P < 0.01). Complete remission rate and overall survival were not different between the two groups. However, cumulative incidence of relapse and event-free survival (EFS) showed an inferior trend in CD56+ APL (P = 0.08 and P = 0.08, respectively). Among patients with initial white blood cell counts of 3.0 × 109/L or more, EFS and cumulative incidence of relapse in CD56+ APL were significantly worse (30.8% vs 63.6%, P = 0.008, and 53.8% vs 28.9%, P = 0.03, respectively), and in multivariate analysis, CD56 expression was an unfavorable prognostic factor for EFS (P = 0.04). In conclusion, for APL with higher initial white blood cell counts, CD56 expression should be regarded as an unfavorable prognostic factor.

Prognostic factors of patients with newly diagnosed acute promyelocytic leukemia treated with arsenic trioxide-based frontline therapy

“…Several studies have reported the unfavorable effect of CD56 expression in the ATRA and chemotherapy-based therapy [22][23][24][25][26][27]. We have found the incidence of CD56 expression to be 15.9%.…”

Immunophenotypic characteristics of early T-cell precursor acute lymphoblastic leukemia

“…Исследование позволило выявить очевидную иммунофенотипическую гетерогенность среди пациентов этой группы: выявлены разные профили коэкспрессирующихся маркеров и уровни их экспрессии. В более ранних исследованиях ETP-ОЛЛ считали подтипом исключительно TI-ОЛЛ, позже эти данные были опровергнуты [21,22]. Мы тоже обнаружили различные варианты Т-ОЛЛ, которые удовлетворяют иммунофенотипическим критериям ETP-ОЛЛ (рисунки 3-7).…”

Neuroendocrine Breast Carcinomas Share Prognostic Factors with Gastroenteropancreatic Neuroendocrine Tumors: A Putative Prognostic Role of Menin, p27, and SSTR-2A

“…It is present in most natural killer cells and in some T cells that take part in cancer cell lysis. CD56 is proposed to be an unfavorable prognostic factor in leukemia [18] and is used as a neuroendocrine tumor marker [19].…”