2016
DOI: 10.18632/aging.101087
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Abstract: Rab1A expression is associated with malignant phenotypes in several human tumors; however, the role of Rab1A in lung cancer is still unclear. In this study, we attempted to establish the role of Rab1A in major human lung cancer subtypes. Rab1A expression in different histological types of human lung cancer was analyzed in lung cancer tissues with paired adjacent noncancerous tissues and a large panel of lung cancer cell lines. The effect of Rab1A expression on multiple cancer-associated signaling pathways was … Show more

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Cited by 30 publications
(21 citation statements)
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References 24 publications
(38 reference statements)
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“…In the current study, we confirmed the overexpression of Rab1A in NPC samples and its positive correlation with tumor metastasis of NPC patients. These results were consistent with previous findings [ 13 , 14 , 26 – 28 ], suggesting that Rab1A may play a commonly oncogenic role in certain types of cancers. In terms of its cellular effects, some studies showed that Rab1A promoted cellular proliferation, invasion and EMT process through activation of mTOR signaling in several cancers [ 13 , 14 , 27 ].…”
Section: Discussionsupporting
confidence: 94%
“…In the current study, we confirmed the overexpression of Rab1A in NPC samples and its positive correlation with tumor metastasis of NPC patients. These results were consistent with previous findings [ 13 , 14 , 26 – 28 ], suggesting that Rab1A may play a commonly oncogenic role in certain types of cancers. In terms of its cellular effects, some studies showed that Rab1A promoted cellular proliferation, invasion and EMT process through activation of mTOR signaling in several cancers [ 13 , 14 , 27 ].…”
Section: Discussionsupporting
confidence: 94%
“…Recently, lots of studies indicated that RAB1A plays important roles in tumor progression. For example, Wang et al [ 30 ] showed that expression of RAB1A was up-regulated in human lung cancer and associated with tumor size and T stage. Xu et al [ 31 ] showed that inhibition of RAB1A suppressed epithelial–mesenchymal transition and proliferation of triple-negative breast cancer cells.…”
Section: Discussionmentioning
confidence: 99%
“…Correlation between RAB1A overexpression and HER-2 amplification. tongue cancer (11) and lung cancer (29). In our previous study, RAB1A was identified as an oncogene in colorectal and liver cancer.…”
Section: Discussionmentioning
confidence: 94%