Expression of Rab1A is upregulated in human lung cancer and associated with tumor size and T stage

Wang, Xinxin; Liu, Feng; Qin, Xiaoyu; Huang, Tinglei; Huang, Bo; Zhang, Yanjie; Jiang, Bin

doi:10.18632/aging.101087

Cited by 32 publications

(23 citation statements)

References 24 publications

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“…In the current study, we confirmed the overexpression of Rab1A in NPC samples and its positive correlation with tumor metastasis of NPC patients. These results were consistent with previous findings [ 13 , 14 , 26 – 28 ], suggesting that Rab1A may play a commonly oncogenic role in certain types of cancers. In terms of its cellular effects, some studies showed that Rab1A promoted cellular proliferation, invasion and EMT process through activation of mTOR signaling in several cancers [ 13 , 14 , 27 ].…”

Section: Discussionsupporting

confidence: 94%

Rab1A promotes cancer metastasis and radioresistance through activating GSK-3β/Wnt/β-catenin signaling in nasopharyngeal carcinoma

Yang

Chen

Zeng

et al. 2020

aging

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Many articles have reported that Rab1A was overexpressed in a variety of human cancers and involved in tumor progression and metastasis. However, the biological function and molecular mechanism of Rab1A in nasopharyngeal carcinoma (NPC) remained unknown until now. Here we found that Rab1A overexpression is a common event and was positively associated with distant metastasis and poor prognosis of NPC patients. Functionally, Rab1A depletion inhibited the migration and EMT phenotype of NPC cells, whereas Rab1A overexpression led to the opposite effect. Furthermore, we reveal an important role for Rab1A protein in the induction of radioresistance via regulating homologous recombination (HR) signaling pathway. Mechanistically, Rab1A activated Wnt/β-catenin signaling by inhibiting the activity of GSK-3β via phosphorylation at Ser9. Then Wnt/β-catenin signaling induced NPC cells radioresistance and metastasis through nuclear translocation of β-catenin and transcription upregulation of HR pathway-related and EMT-related genes expression. In general, this study shows that Rab1A may serve as a potential biomarker for predicting prognosis in NPC patients. Targeting Rab1A and Wnt/β-catenin signaling may hold promise to overcome NPC radioresistance.

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Section: Discussionsupporting

confidence: 94%

Rab1A promotes cancer metastasis and radioresistance through activating GSK-3β/Wnt/β-catenin signaling in nasopharyngeal carcinoma

Yang

Chen

Zeng

et al. 2020

aging

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“…Recently, lots of studies indicated that RAB1A plays important roles in tumor progression. For example, Wang et al [ 30 ] showed that expression of RAB1A was up-regulated in human lung cancer and associated with tumor size and T stage. Xu et al [ 31 ] showed that inhibition of RAB1A suppressed epithelial–mesenchymal transition and proliferation of triple-negative breast cancer cells.…”

Section: Discussionmentioning

confidence: 99%

LncRNA DANCR functions as a competing endogenous RNA to regulate RAB1A expression by sponging miR-634 in glioma

Gao

et al. 2018

Bioscience Reports

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Long noncoding RNA (lncRNA) differentiation antagonizing nonprotein coding RNA (DANCR) plays important regulatory roles in many solid tumors. However, the effect of DANCR in glioma progression and underlying molecular mechanisms were not entirely explored. In the present study, we determined the expression of DANCR in glioma tissues and cell lines using qRT-PCR and further defined the biological functions. Furthermore, we used luciferase reporter assay, Western blot, and RNA immunoprecipitation (RIP) to explore the underlying mechanism. Our results showed that DANCR was significantly up-regulated in glioma tissues and cell lines (U251, U118, LN229, and U87MG). High DANCR expression was correlated with advanced tumor grade. Inhibition of DANCR suppressed the glioma cells proliferation and induced cells arrested in the G0/G1 phase. In addition, we verified that DANCR could directly interact with miR-634 in glioma cells and this interaction resulted in the inhibition of downstream of RAB1A expression. The present study demonstrated that DANCR/miR-634/RAB1A axis plays crucial roles in the progression of glioma, and DANCR might potentially serve as a therapeutic target for the treatment of glioma patients.

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“…Correlation between RAB1A overexpression and HER-2 amplification. tongue cancer (11) and lung cancer (29). In our previous study, RAB1A was identified as an oncogene in colorectal and liver cancer.…”

Section: Discussionmentioning

confidence: 94%

Significance and prognostic role of human epidermal growth factor receptor 2 and RAB1A expression in gastric cancer

Huang

Yang

et al. 2018

Oncol Lett

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Abstract. Human epidermal growth factor receptor 2 (HER-2) has an important clinical role in various cancers. However, the prognostic impact of HER-2 in gastric cancer (GC) is controversial. RAB1A is an important small molecule in the mechanistic target of rapamycin signalling pathway, which is one of the downstream signalling pathways of the epidermal growth factor receptor family. In recent years, the aberrant expression of RAB1A has been reported in a number of tumours, but its regulation in GC has not been extensively examined. Therefore, the present study investigated the expression pattern and prognostic significance of HER-2 and RAB1A in gastric adenocarcinoma (CAG). A comprehensive analysis was performed to examine the expression level of HER-2 and RAB1A in 280 cases of paired paraffin-embedded GAC tissues and an additional 120 archived GAC tissue samples. HER-2 and RAB1A protein expression was assessed by immunohistochemistry and cases with a 2+ score for HER-2 expression levels were subjected to fluorescence in situ hybridization to determine the HER-2 amplification status. Furthermore, HER-2 and RAB1A mRNA expression was quantified by reverse transcription-quantitative polymerase chain reaction. The comparison of continuous data between two groups was performed using a paired-samples t-test. Clinical correlations were determined using Pearson's Chi-square and Fisher's exact tests. Kaplan-Meier survival curves were used to estimate overall survival (OS). Cox proportional hazards models were used to determine associations between HER-2 and RAB1A expression and outcomes. Regression analyses were performed to detect the correlation between the mRNA levels of HER-2 and RAB1A in GAC tissues. It was observed that RAB1A was significantly overexpressed in GAC tissues compared with normal tissues (P<0.001). Approximately 12.86% of the 280 GAC patients had HER-2 amplification. Additionally, RAB1A expression was significantly associated with a short OS (P<0.001) but there were no significant differences in survival between the HER-2 high-expression group and the HER-2 low-expression group. Additionally, the co-expression of HER-2 and RAB1A indicated poorer OS than the overexpression of each protein (P=0.001), and the two factors were significantly positively correlated in GAC (P= 0.012). These findings may be used to further explore the molecular mechanisms and regulatory associations among signalling pathways in GC.

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Expression of Rab1A is upregulated in human lung cancer and associated with tumor size and T stage

Cited by 32 publications

References 24 publications

Rab1A promotes cancer metastasis and radioresistance through activating GSK-3β/Wnt/β-catenin signaling in nasopharyngeal carcinoma

Rab1A promotes cancer metastasis and radioresistance through activating GSK-3β/Wnt/β-catenin signaling in nasopharyngeal carcinoma

LncRNA DANCR functions as a competing endogenous RNA to regulate RAB1A expression by sponging miR-634 in glioma

Significance and prognostic role of human epidermal growth factor receptor 2 and RAB1A expression in gastric cancer

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Expression of Rab1A is upregulated in human lung cancer and associated with tumor size and T stage

Cited by 32 publications

References 24 publications

Rab1A promotes cancer metastasis and radioresistance through activating GSK-3&#x3B2;/Wnt/&#x3B2;-catenin signaling in nasopharyngeal carcinoma

Rab1A promotes cancer metastasis and radioresistance through activating GSK-3&#x3B2;/Wnt/&#x3B2;-catenin signaling in nasopharyngeal carcinoma

LncRNA DANCR functions as a competing endogenous RNA to regulate RAB1A expression by sponging miR-634 in glioma

Significance and prognostic role of human epidermal growth factor receptor 2 and RAB1A expression in gastric cancer

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Rab1A promotes cancer metastasis and radioresistance through activating GSK-3β/Wnt/β-catenin signaling in nasopharyngeal carcinoma

Rab1A promotes cancer metastasis and radioresistance through activating GSK-3β/Wnt/β-catenin signaling in nasopharyngeal carcinoma