Expression of p53 protein is an early event in ultraviolet light-induced cutaneous squamous cell carcinogenesis

Sequencing of Cutaneous Squamous Cell Carcinoma Primary Tumors and Patient-Matched Metastases Reveals ALK as a Potential Driver in Metastases and Low Mutational Concordance in Immunocompromised Patients

“…Several mutations detected in our cohort are well established in SCC, including TP53 , NOTCH1 , and CDKN2A ( Brown et al., 2004 ; Nagano et al., 1993 ; Wang et al., 2011 ). To our knowledge, this is the first report of ALK as a potential driver mutation in metastatic SCC.…”

Sequencing of Cutaneous Squamous Cell Carcinoma Primary Tumors and Patient-Matched Metastases Reveals ALK as a Potential Driver in Metastases and Low Mutational Concordance in Immunocompromised Patients

“…Several mutations detected in our cohort are well established in SCC, including TP53 , NOTCH1 , and CDKN2A ( Brown et al., 2004 ; Nagano et al., 1993 ; Wang et al., 2011 ). To our knowledge, this is the first report of ALK as a potential driver mutation in metastatic SCC.…”

Immunohistochemical Detection of p53 Tumor Suppressor Protein in Porokeratosis

“…Moreover, the epidermis beneath and central to cornoid lamellae, which is likely to be lesional (6), was not entirely, but rather locally, stained in the specimens examined here. Immunohistological p53 overexpression has been observed in other precancerous lesions of the skin (12). Based on these factors, we would speculate that abnormal p53 expression is not essential for the pathogenesis of porokeratosis but has some relevance to its skin carcinogenesis.…”

“…p53 expression has been examined in SCCs with various predispositions, including sun exposure, scar tissue, radiation dermatitis, and dystrophic epidermolysis bullosa (12)(13)(14)(15). Although we previously reported frequent p53 overexpression in multiple SCCs developing in a patient with linear porokeratosis (10), no other studies of p53 expression in SCC associated with porokeratosis have been performed.…”

Actinic cheilitis: histopathology and p53

“…Regardless of most AC (85%) 8 and tumors (80%) 26,27 that were immunoreactive to the p53 protein (Table 2), only the intensity 28 and location 29,30 of the p53 protein staining in the epithelium had a significant association with the percentage of p53 in the AC (Tables 3 and 4). As the level of p53 positivity of tumors had no correlation with intensity of staining or location, we do not consider it as marker of transformation or progression of the AC to SCC.…”

“…32 We consider that the p53 mutations, necessary for the malignant phenotype, may have occurred prior to the tumor invasion in cases of p53 immunoreactive tumors and both positive and negative cheilitis. 26 Seven of 16 controls (44%) expressed p53 protein. This may be due to an increased expression of the normal p53 protein, stimulated by the ultraviolet irradiation.…”

Sequencing of Cutaneous Squamous Cell Carcinoma Primary Tumors and Patient-Matched Metastases Reveals ALK as a Potential Driver in Metastases and Low Mutational Concordance in Immunocompromised Patients

“…Several mutations detected in our cohort are well established in SCC, including TP53 , NOTCH1 , and CDKN2A ( Brown et al., 2004 ; Nagano et al., 1993 ; Wang et al., 2011 ). To our knowledge, this is the first report of ALK as a potential driver mutation in metastatic SCC.…”

Immunohistochemical Detection of p53 Tumor Suppressor Protein in Porokeratosis

“…Moreover, the epidermis beneath and central to cornoid lamellae, which is likely to be lesional (6), was not entirely, but rather locally, stained in the specimens examined here. Immunohistological p53 overexpression has been observed in other precancerous lesions of the skin (12). Based on these factors, we would speculate that abnormal p53 expression is not essential for the pathogenesis of porokeratosis but has some relevance to its skin carcinogenesis.…”

“…p53 expression has been examined in SCCs with various predispositions, including sun exposure, scar tissue, radiation dermatitis, and dystrophic epidermolysis bullosa (12)(13)(14)(15). Although we previously reported frequent p53 overexpression in multiple SCCs developing in a patient with linear porokeratosis (10), no other studies of p53 expression in SCC associated with porokeratosis have been performed.…”

Actinic cheilitis: histopathology and p53

“…Regardless of most AC (85%) 8 and tumors (80%) 26,27 that were immunoreactive to the p53 protein (Table 2), only the intensity 28 and location 29,30 of the p53 protein staining in the epithelium had a significant association with the percentage of p53 in the AC (Tables 3 and 4). As the level of p53 positivity of tumors had no correlation with intensity of staining or location, we do not consider it as marker of transformation or progression of the AC to SCC.…”

“…32 We consider that the p53 mutations, necessary for the malignant phenotype, may have occurred prior to the tumor invasion in cases of p53 immunoreactive tumors and both positive and negative cheilitis. 26 Seven of 16 controls (44%) expressed p53 protein. This may be due to an increased expression of the normal p53 protein, stimulated by the ultraviolet irradiation.…”

Sequencing of Cutaneous Squamous Cell Carcinoma Primary Tumors and Patient-Matched Metastases Reveals ALK as a Potential Driver in Metastases and Low Mutational Concordance in Immunocompromised Patients

“…Several mutations detected in our cohort are well established in SCC, including TP53 , NOTCH1 , and CDKN2A ( Brown et al., 2004 ; Nagano et al., 1993 ; Wang et al., 2011 ). To our knowledge, this is the first report of ALK as a potential driver mutation in metastatic SCC.…”

Immunohistochemical Detection of p53 Tumor Suppressor Protein in Porokeratosis

“…Moreover, the epidermis beneath and central to cornoid lamellae, which is likely to be lesional (6), was not entirely, but rather locally, stained in the specimens examined here. Immunohistological p53 overexpression has been observed in other precancerous lesions of the skin (12). Based on these factors, we would speculate that abnormal p53 expression is not essential for the pathogenesis of porokeratosis but has some relevance to its skin carcinogenesis.…”

“…p53 expression has been examined in SCCs with various predispositions, including sun exposure, scar tissue, radiation dermatitis, and dystrophic epidermolysis bullosa (12)(13)(14)(15). Although we previously reported frequent p53 overexpression in multiple SCCs developing in a patient with linear porokeratosis (10), no other studies of p53 expression in SCC associated with porokeratosis have been performed.…”

Actinic cheilitis: histopathology and p53

“…Regardless of most AC (85%) 8 and tumors (80%) 26,27 that were immunoreactive to the p53 protein (Table 2), only the intensity 28 and location 29,30 of the p53 protein staining in the epithelium had a significant association with the percentage of p53 in the AC (Tables 3 and 4). As the level of p53 positivity of tumors had no correlation with intensity of staining or location, we do not consider it as marker of transformation or progression of the AC to SCC.…”

“…32 We consider that the p53 mutations, necessary for the malignant phenotype, may have occurred prior to the tumor invasion in cases of p53 immunoreactive tumors and both positive and negative cheilitis. 26 Seven of 16 controls (44%) expressed p53 protein. This may be due to an increased expression of the normal p53 protein, stimulated by the ultraviolet irradiation.…”