Expression of P2X1 receptors in somatostatin-containing cells in mouse gastrointestinal tract and pancreatic islets of both mouse and human

Ji, Ruihua; Zhu, Junjun; Wang, Dan; Sui, Qian-Qian; Knight, Gillian E.; Burnstock, Geoffrey; Yuan, Hongbin; Xiang, Zhenghua

doi:10.1007/s11302-018-9615-6

Cited by 3 publications

(2 citation statements)

References 31 publications

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“…In the rat submucous plexus, SOM-positive neurons have been divided into two groups: those containing both CGRP and SP (60% of all neurons immunoreactive to SOM) and those containing only CGRP without SP [64]. In turn, the latest studies have shown the presence of chemokine CXCL 14 and P2X1 receptors in the SOM-positive nervous structures in the mouse digestive tract, which suggests that CXCL14 contributes to the function of somatostatin in the enteric neuron system and that ATP may participate in SOM release from the enteric neurons [72,73].…”

Section: The Presence Of Somatostatin (Som) In the Enteric Neuronsmentioning

confidence: 99%

Somatostatin as an Active Substance in the Mammalian Enteric Nervous System

Gonkowski

Rytel

2019

IJMS

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Somatostatin (SOM) is an active substance which most commonly occurs in endocrine cells, as well as in the central and peripheral nervous system. One of the parts of the nervous system where the presence of SOM has been confirmed is the enteric nervous system (ENS), located in the wall of the gastrointestinal (GI) tract. It regulates most of the functions of the stomach and intestine and it is characterized by complex organization and a high degree of independence from the central nervous system. SOM has been described in the ENS of numerous mammal species and its main functions in the GI tract are connected with the inhibition of the intestinal motility and secretory activity. Moreover, SOM participates in sensory and pain stimuli conduction, modulation of the release of other neuronal factors, and regulation of blood flow in the intestinal vessels. This peptide is also involved in the pathological processes in the GI tract and is known as an anti-inflammatory agent. This paper, which focuses primarily on the distribution of SOM in the ENS and extrinsic intestinal innervation in various mammalian species, is a review of studies concerning this issue published from 1973 to the present.

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Section: The Presence Of Somatostatin (Som) In the Enteric Neuronsmentioning

confidence: 99%

Somatostatin as an Active Substance in the Mammalian Enteric Nervous System

Gonkowski

Rytel

2019

IJMS

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“…Oral treatment (Lactobacillus plantarum ys2) in carbon-induced constipation Kunming mice reduced serum SST level, promoted gastrointestinal peristalsis, and reduced the first black stool defecation time ( 54 ). SST immunoreactive neurons co-expressed with P2X1-receptor (ATP receptor) was detected in mouse myenteric and submucosal plexuses ( 55 ). Using intrinsic markers targeting vagal and spinal sensory, sympathetic, and parasympathetic axons, the spatiotemporal map showed extrinsic axons project along the myenteric plexus and keep intimate contact with enteric neurons in whole gut in mice E9.5-E16.5 ( 56 ).…”

Section: Sst-enteric Endocrine Cells and Nervous System In The Gastromentioning

confidence: 99%

Versatile Functions of Somatostatin and Somatostatin Receptors in the Gastrointestinal System

Shamsi¹,

Chatoo²,

Xu³

et al. 2021

Front. Endocrinol.

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Somatostatin (SST) and somatostatin receptors (SSTRs) play an important role in the brain and gastrointestinal (GI) system. SST is produced in various organs and cells, and the inhibitory function of somatostatin-containing cells is involved in a range of physiological functions and pathological modifications. The GI system is the largest endocrine organ for digestion and absorption, SST-endocrine cells and neurons in the GI system are a critical effecter to maintain homeostasis via SSTRs 1-5 and co-receptors, while SST-SSTRs are involved in chemo-sensory, mucus, and hormone secretion, motility, inflammation response, itch, and pain via the autocrine, paracrine, endocrine, and exoendocrine pathways. It is also a power inhibitor for tumor cell proliferation, severe inflammation, and post-operation complications, and is a first-line anti-cancer drug in clinical practice. This mini review focuses on the current function of producing SST endocrine cells and local neurons SST-SSTRs in the GI system, discusses new development prognostic markers, phosphate-specific antibodies, and molecular imaging emerging in diagnostics and therapy, and summarizes the mechanism of the SST family in basic research and clinical practice. Understanding of endocrines and neuroendocrines in SST-SSTRs in GI will provide an insight into advanced medicine in basic and clinical research.

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The Human Islet: Mini-Organ With Mega-Impact

2021

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This review focuses on the human pancreatic islet – including its structure, cell composition, development, function, and dysfunction. After providing a historical timeline of key discoveries about human islets over the past century, we describe new research approaches and technologies that are being used to study human islets and how these are providing insight into human islet physiology and pathophysiology. We also describe changes or adaptations in human islets in response to physiologic challenges such as pregnancy, aging, and insulin resistance and discuss islet changes in human diabetes of many forms. We outline current and future interventions being developed to protect, restore, or replace human islets. The review also highlights unresolved questions about human islets and proposes areas where additional research on human islets is needed.

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Expression of P2X1 receptors in somatostatin-containing cells in mouse gastrointestinal tract and pancreatic islets of both mouse and human

Cited by 3 publications

References 31 publications

Somatostatin as an Active Substance in the Mammalian Enteric Nervous System

Somatostatin as an Active Substance in the Mammalian Enteric Nervous System

Versatile Functions of Somatostatin and Somatostatin Receptors in the Gastrointestinal System

The Human Islet: Mini-Organ With Mega-Impact

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