Expression of p16 protein in lesional and perilesional condyloma acuminata and bowenoid papulosis: Clinical significance and diagnostic implications

Kazlouskaya, Viktoryia; Shustef, Elina; Allam, Sherihan H.; Lal, Karan; Elston, Dirk M.

doi:10.1016/j.jaad.2013.04.036

Cited by 19 publications

(21 citation statements)

References 28 publications

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“…Positive p16 immunostaining has been used as a biomarker of high‐grade dysplasia and malignancy, particularly in cervical specimens . In non‐mucosal skin, p16 immunostaining is able to discriminate typical cases of condyloma acuminatum (CA) from bowenoid papulosis (BP), with perfect concordance to hematoxylin and eosin (H&E) findings …”

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confidence: 99%

“…1,2 In non-mucosal skin, p16 immunostaining is able to discriminate typical cases of condyloma acuminatum (CA) from bowenoid papulosis (BP), with perfect concordance to hematoxylin and eosin (H&E) findings. 3 Based largely on studies of cervical specimens, a consensus panel recently convened by the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology recommended p16 staining in cutaneous cases with intraepithelial lesions of uncertain degree of dysplasia between grade 2 dysplasia (-IN 2) and possible high-grade dysplasia. 4 This recommendation for p16 immunostaining of equivocal lesions presumes an ultimate diagnosis of low-grade squamous intraepithelial lesion (LSIL) for negative p16 staining and high-grade squamous intraepithelial lesion (HSIL) for positive p16 staining in a case of -IN 2.…”

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confidence: 99%

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Grading of atypia in genital skin lesions: routine microscopic evaluation and use of p16 immunostaining

et al. 2015

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Grading of atypia in genital skin lesions: routine microscopic evaluation and use of p16 immunostaining

et al. 2015

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“…PCR HPV typing is helpful for distinguishing black lesions of CA from those of BP. Recently, Kazlouskaya et al . reported that p16 staining is a powerful tool for differentiating CA from BP.…”

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confidence: 99%

“…PCR HPV typing is helpful for distinguishing black lesions of CA from those of BP. Recently, Kazlouskaya et al 12 reported that p16 staining is a powerful tool for differentiating CA from BP. The authors clearly showed that diffuse p16 staining is observed in the lesions of BP, while only sporadic or focal p16 staining is noted in the lesions of CA.…”

Section: Discussionmentioning

confidence: 99%

Pigmented condyloma acuminatum

Shimizu

Kato

Ishikawa

2014

The Journal of Dermatology

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We herein report a case of pigmented condyloma acuminatum in the genital region. A histopathological examination revealed keratinocyte proliferation, papillomatosis and basal pigmentation. Cellular atypia was rarely observed. The patient also had ordinary skin-colored nodules on the coronal sulcus. Polymerase chain reaction amplification with consensus primers for human papillomavirus (HPV) and subsequent sequencing confirmed an infection of HPV type 6. Pigmented condyloma acuminatum is not rare; however, making the differential diagnosis between bowenoid papulosis and seborrheic keratosis is sometimes difficult. The mechanism of pigmentation in such cases remains unknown and requires further investigation. HPV typing is a useful method for diagnosing the disease.

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“…However, it is sometimes difficult to distinguish CA from BP and SK when CA manifests as pigmented lesions. Very recently, Kazlouskaya et al (4) reported that p16 staining is a powerful tool for differentiation CA from BP.…”

Section: Diagnosis: Condyloma Accuminata and Seborrhoeic Keratosismentioning

confidence: 99%

Multiple Perianal Nodules in an HIV-positive Man: A Quiz

Suzuki

Niiyama²,

Yokouchi³

et al. 2015

Acta Derm Venerol

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A 39-year-old homosexual man presented with a 2-month history of nodules around the perianal region. He was HIV-1-positive, with no related symptoms, and was followed without treatment at another hospital. Physical examination revealed a 10-mm pink nodule and several smaller gray nodules coalesced around the perianal region (Fig. 1). Histopathological examination of the pink nodule reveled hyperkeratosis, papillomatosis, and acanthosis (Fig. 2a). Biopsy of a gray nodule showed a warty lesion composed of proliferating basaloid cells resulting in acanthotic epidermal rete ridges (Fig. 2b). Fig. 1. A 10-mm pink nodule and small gray nodules coalesced around the perianal region.Fig. 2. Pink nodule showed hyperkeratosis, acanthosis, and papillomatosis (a). Gray nodule composed of proliferation epidermis with elongated and expanded rete ridges (b). (Haematoxylin-eosin stain; original magnification: a: × 12.5; b: × 40).

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Expression of p16 protein in lesional and perilesional condyloma acuminata and bowenoid papulosis: Clinical significance and diagnostic implications

Cited by 19 publications

References 28 publications

Grading of atypia in genital skin lesions: routine microscopic evaluation and use of p16 immunostaining

Grading of atypia in genital skin lesions: routine microscopic evaluation and use of p16 immunostaining

Pigmented condyloma acuminatum

Multiple Perianal Nodules in an HIV-positive Man: A Quiz

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