Expression of neurotrophin receptors in B cell lines of normal and malignant origin

Neurotrophins and B-cell malignancies

“…p75 NTR mRNA expression was observed in human B cells, but could not be detected at the protein level [108].…”

“…Expression of all three Trk receptors has been shown in human B cells [108]. TrkA is expressed in both resting and activated B cells [105] as well as in the CESS cell line [106].…”

“…It has been suggested that TrkB may be cytoplasmically sequestered in resting B cells, and relocated to the cell surface upon B cell stimulation [107]. Relatively little is known about TrkC expression in B lymphocytes, but mRNA expression has been seen in human B cells [108].…”

“…BDNF from stromal cells promoted pre-B cell maturation through TrkB signalling by immature B cells [109]. BDNF has been shown to be able to reduce the level of apoptosis in mature B cell lines during serum starvation [108]. It has also been suggested that the BDNFmediated anti-apoptotic signaling may be linked to the upregulation of FLICE-inhibitory protein (FLIP), as shown in neural cells [116].…”

“…Resting and activated human B cells [104] Higher in memory B cells [104] and memory-like B cell line [105] Proliferation of memory-like B cell line (CESS) and B lymphocytes in vitro [105,117] Survival of memory B lymphocytes in vitro and memory-like B cell line (CESS) [104,105] Differentiation/IgM production of B lymphocytes in vitro [104,118] IgG and IgA production from resting and activated B lymphocytes in vitro [118] IL-2R expression by activated B lymphocytes in vitro [119] CD40 expression by B lymphocytes in vitro [119] IgE inhibition in B lymphocytes in vitro [121] BDNF Activated human B cells [104] B cell lines [106] Maturation of B cells in vivo from Pre-BII stage in murine bone marrow [108] Survival of B lymphocytes in vitro with serum deprivation [106] Apoptosis induction (by pro-BDNF) in a mature B cell line (BL2) in vitro [106] …”