2006
DOI: 10.1590/s0004-282x2006000500015
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Expression of nestin and vimentin in gliomatosis cerebri

Abstract: Gliomatosis cerebri (GC) is a rare form of CNS neoplasia in which there is diffuse involvement of the nervous tissue with or without the presence of tumor mass. The origin of the tumor is unknown, nor whether it represents a disease with diffuse onset or infiltration from a neoplastic focus. Here we studied the histopathologic characteristics of 6 cases with a diagnosis of GC and performed an immunohistochemical analysis using glial fibrillary acidic protein (GFAP), synaptophysin, nestin and vimentin. Most tum… Show more

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Cited by 14 publications
(11 citation statements)
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“…Further, these model results suggest exploration of invasion-specific markers (e.g. MMP-2 (33), vimentin (34)) may enhance the prognostic accuracy of the current grading scheme. Admittedly, assessing invasion from fixed histological sections of dead tissue is a true challenge.…”
Section: Discussionmentioning
confidence: 92%
“…Further, these model results suggest exploration of invasion-specific markers (e.g. MMP-2 (33), vimentin (34)) may enhance the prognostic accuracy of the current grading scheme. Admittedly, assessing invasion from fixed histological sections of dead tissue is a true challenge.…”
Section: Discussionmentioning
confidence: 92%
“…Low expression of the Ki-67 protein implied low cell proliferation. These findings led us to the diagnosis of a low grade, malignant (WHO I) pilocytic astrocytoma according to the relative literature [7,10,12,20].…”
Section: Discussionmentioning
confidence: 99%
“…The poor outcome for these patients and low survival rates was also mentioned by Bruna and Velasco (2010). Hilbig et al (2006) demonstrated that most tumour cells were negative for GFAP even though there were foci of positivity for this marker. However, the authors detected the presence of many cells positive for nestin and vimentin.…”
Section: Discussionmentioning
confidence: 66%