Expression of monocyte chemoattractant protein-1 and other β-chemokines by resident glia and inflammatory cells in multiple sclerosis lesions

Chemokines and chemokine receptors in CNS pathology

“…MCP-1 immunoreactivity was detected in reactive microglia and mature but not in immature senile plaques in autopsy specimens from ®ve Alzheimer disease patients (Ishizuka et al, 1997). Simpson and coworkers demonstrated expression of MCP-1 protein by astrocytes bordering active MS lesions, compatible with prior observations in EAE, trauma and cerebral ischemia models (Simpson et al, 1998). Hvas et al showed that RANTES mRNA was expressed by perivascular in¯ammatory cells in MS brain sections as previously reported in EAE (Hvas et al, 1997).…”

Genetics of primary progressive multiple sclerosis

“…The chemokine receptor CCR5 is expressed in actively demyelinating plaques (Simpson et al, 1998;Balashov et al, 1999;Sorensen et al, 1999) and its chemokine ligands macrophage inflammatory protein-1a and -1b (MIP-1a, MIP-1b) and RANTES (regulated on activation, normal T cell expressed and secreted) are elevated in the cerebrospinal fluid (CSF) of patients experiencing relapses (Miyagishi et al, 1995;Mahad et al, 2002). A 32-basepair deletion in the coding region of CCR5 (CCR5 d32) abolishes CCR5 function and may impair entry of inflammatory cells into MS lesions.…”

IFN-γ Shapes Immune Invasion of the Central Nervous System Via Regulation of Chemokines

“…Chemokines, including RANTES, MIP-1␣, MCP-1, and IFN␥-inducible protein-10 (IP-10), and chemokine receptors are up-regulated in MS and EAE, and their expression has been shown to correlate with the distribution of CNS inflammatory infiltrates and clinical disease activity (15)(16)(17)(18)(19)(20)(21)(22). Anti-MIP-1␣ mAb treatment and vaccination with naked DNA encoding MIP-1␣ and MCP-1 prevented EAE in rodents (23,24), and anti-MCP-1 mAb treatment attenuated relapses of EAE (25).…”