Expression of L‐type amino acid transporter 1 (LAT1) and 4F2 heavy chain (4F2hc) in liver tumor lesions of rat models

Abstract

LAT1 was related to tumor growth. We think that LAT1 can possibly enhance its ability to promote tumor growth in cooperation with 4F2hc.

Expression of L-type amino acid transporter 1 (LAT1) in esophageal carcinoma

“…We compared LAT1 expression between tumors with diameters of <3 and !3 cm, between <4 and !4 cm, and between <5 and !5 cm, and found that LAT1 was more strongly expressed in esophageal squamous cell carcinoma with a maximum tumor diameter of 4 cm or greater compared to that with a diameter of less than 4 cm. This finding supported the finding that LAT1 expression increased with the size of liver metastases in a rat colon carcinoma liver metastasis model reported by Tamai et al [7]. However, the important prognostic factor in esophageal squamous cell carcinoma was the presence or absence of lymph node metastasis, and LAT1 expression was not different between cases with and without lymph node metastasis.…”

Expression of L-type amino acid transporter 1 (LAT1) in esophageal carcinoma

“…We compared LAT1 expression between tumors with diameters of <3 and !3 cm, between <4 and !4 cm, and between <5 and !5 cm, and found that LAT1 was more strongly expressed in esophageal squamous cell carcinoma with a maximum tumor diameter of 4 cm or greater compared to that with a diameter of less than 4 cm. This finding supported the finding that LAT1 expression increased with the size of liver metastases in a rat colon carcinoma liver metastasis model reported by Tamai et al [7]. However, the important prognostic factor in esophageal squamous cell carcinoma was the presence or absence of lymph node metastasis, and LAT1 expression was not different between cases with and without lymph node metastasis.…”

Divergent expression of L-type amino acid transporter 1 during uterine cervical carcinogenesis

“…The number of LAT1-positive cells tended to be lower in adenocarcinoma than in SCC, in agreement with a reported lung cancer study, in which lower LAT1 expression in adenocarcinoma than in other histologic subtypes was described [17,24]. As have been shown in the liver in the rat model, various cancer cells including adenocarcinoma may also make use of LAT1 for their proliferation [20]. Regardless of the histologic phenotypes, increased LAT1 expression was a common finding in invasive carcinoma in the uterine cervix in the present study, as reported in other tumors such as lung [17,18,25], esophagus [5], breast [26], bladder [27], colon [20,28], thyroid [29], prostate [12], and glioma [30,31].…”

Prognostic significance of L‐type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in early stage squamous cell carcinoma of the lung

“…(18)(19)(20) Ohkame et al reported the overexpression of CD98 in the metastatic liver tumor of rat models. (21) In the present study, no expression of CD98 protein was observed in any normal epithelial cells of the lung, including bronchial epithelium and alveolar cells. These results suggest that CD98 may have a role in tumor progression and metastasis, and CD98 is expressed above a normal threshold value.…”

Expression of L-type amino acid transporter 1 (LAT1) in esophageal carcinoma

“…We compared LAT1 expression between tumors with diameters of <3 and !3 cm, between <4 and !4 cm, and between <5 and !5 cm, and found that LAT1 was more strongly expressed in esophageal squamous cell carcinoma with a maximum tumor diameter of 4 cm or greater compared to that with a diameter of less than 4 cm. This finding supported the finding that LAT1 expression increased with the size of liver metastases in a rat colon carcinoma liver metastasis model reported by Tamai et al [7]. However, the important prognostic factor in esophageal squamous cell carcinoma was the presence or absence of lymph node metastasis, and LAT1 expression was not different between cases with and without lymph node metastasis.…”

Divergent expression of L-type amino acid transporter 1 during uterine cervical carcinogenesis

“…The number of LAT1-positive cells tended to be lower in adenocarcinoma than in SCC, in agreement with a reported lung cancer study, in which lower LAT1 expression in adenocarcinoma than in other histologic subtypes was described [17,24]. As have been shown in the liver in the rat model, various cancer cells including adenocarcinoma may also make use of LAT1 for their proliferation [20]. Regardless of the histologic phenotypes, increased LAT1 expression was a common finding in invasive carcinoma in the uterine cervix in the present study, as reported in other tumors such as lung [17,18,25], esophagus [5], breast [26], bladder [27], colon [20,28], thyroid [29], prostate [12], and glioma [30,31].…”

Prognostic significance of L‐type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in early stage squamous cell carcinoma of the lung

“…(18)(19)(20) Ohkame et al reported the overexpression of CD98 in the metastatic liver tumor of rat models. (21) In the present study, no expression of CD98 protein was observed in any normal epithelial cells of the lung, including bronchial epithelium and alveolar cells. These results suggest that CD98 may have a role in tumor progression and metastasis, and CD98 is expressed above a normal threshold value.…”

Expression of L-type amino acid transporter 1 (LAT1) in esophageal carcinoma

“…We compared LAT1 expression between tumors with diameters of <3 and !3 cm, between <4 and !4 cm, and between <5 and !5 cm, and found that LAT1 was more strongly expressed in esophageal squamous cell carcinoma with a maximum tumor diameter of 4 cm or greater compared to that with a diameter of less than 4 cm. This finding supported the finding that LAT1 expression increased with the size of liver metastases in a rat colon carcinoma liver metastasis model reported by Tamai et al [7]. However, the important prognostic factor in esophageal squamous cell carcinoma was the presence or absence of lymph node metastasis, and LAT1 expression was not different between cases with and without lymph node metastasis.…”

Divergent expression of L-type amino acid transporter 1 during uterine cervical carcinogenesis

“…The number of LAT1-positive cells tended to be lower in adenocarcinoma than in SCC, in agreement with a reported lung cancer study, in which lower LAT1 expression in adenocarcinoma than in other histologic subtypes was described [17,24]. As have been shown in the liver in the rat model, various cancer cells including adenocarcinoma may also make use of LAT1 for their proliferation [20]. Regardless of the histologic phenotypes, increased LAT1 expression was a common finding in invasive carcinoma in the uterine cervix in the present study, as reported in other tumors such as lung [17,18,25], esophagus [5], breast [26], bladder [27], colon [20,28], thyroid [29], prostate [12], and glioma [30,31].…”

Prognostic significance of L‐type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in early stage squamous cell carcinoma of the lung

“…(18)(19)(20) Ohkame et al reported the overexpression of CD98 in the metastatic liver tumor of rat models. (21) In the present study, no expression of CD98 protein was observed in any normal epithelial cells of the lung, including bronchial epithelium and alveolar cells. These results suggest that CD98 may have a role in tumor progression and metastasis, and CD98 is expressed above a normal threshold value.…”